A Case of Immunoglobulin G4-Related Sclerosing Disease Mimicking Lung Cancer

Kwon, Soo Hee; Lee, Young Kyung; Shim, Mi Suk; Lee, Hyang Im

doi:10.3348/jksr.2013.69.1.53

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…To our knowledge, our present case is the first Korean IgG4-RD patient presenting with interstitial lung disease. Although a total of 6 Korean cases of IgG4-related lung and pleural disease have been reported in the literature, these cases showed multiple lung nodules or masses 10 , 11 , consolidative masses 12 , or pleural nodules 13 , 14 mimicking a malignancy. Our case showed relatively rapidly progressive (within 1 year) pleural and subpleural fibrosis with diffuse GGOs in both upper lobes, which is an uncommon presentation.…”

Section: Discussionmentioning

confidence: 99%

A Case of IgG4-Related Lung Disease Presenting as Interstitial Lung Disease

et al. 2014

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Intrathoracic involvement of immunoglobulin G4 (IgG4)-related disease has recently been reported. However, a subset of the disease presenting as interstitial lung disease is rare. Here, we report a case of a 35-year-old man with IgG4-related lung disease with manifestations similar to those of interstitial lung disease. Chest computed tomography showed diffuse ground glass opacities and rapidly progressive pleural and subpleural fibrosis in both upper lobes. Histological findings showed diffuse interstitial lymphoplasmacytic infiltration with an increased number of IgG4-positive plasma cells. Serum levels of IgG and IgG4 were also increased. The patient was diagnosed with IgG4-related lung disease, treated with anti-inflammatory agents, and showed improvement. Lung involvement of IgG4-related disease can present as interstitial lung disease and, therefore, should be differentiated when evaluating interstitial lung disease.

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Section: Discussionmentioning

confidence: 99%

A Case of IgG4-Related Lung Disease Presenting as Interstitial Lung Disease

et al. 2014

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“…These cases showed multiple lung nodules or mass 6 7 , consolidative mass 8 , pleural nodules or mass 9 10 , pleural effusion 11 , interstitial lung disease 12 , or bronchovascular bundle thickening 13 in chest CT, and accompanying symptoms were cough, sputum, fever, dyspnea, or asymptomatic. All serum IgG4 levels in Korea cases elevated except the case of bronchial thickening with eosinophilic angiocentric fibrosis patient, in which case serum IgG level was normal and serum IgG4 level was not mentioned 6 7 8 9 10 11 12 13 . However, in our case presenting symptom was hemoptysis and serum IgG4 level was normal.…”

Section: Discussionmentioning

confidence: 99%

IgG4-Related Lung Disease without Elevation of Serum IgG4 Level: A Case Report

et al. 2016

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Since IgG4-related pancreatitis was first reported in 2001, IgG4-related disease has been identified in other organs such as salivary gland, gallbladder, thyroid, retroperitoneum and kidney; but lung invasion is rare. A 63-year-old man presented with hemoptysis at the pulmonary clinic and chest computed tomography revealed about 4.1 cm irregular shaped mass with spiculated margin at the left upper lobe. Despite no elevation of serum IgG4 level, he was finally diagnosed as IgG4-related lung disease by transthoracic needle biopsy. After treatment with oral glucocorticoids, hemoptysis disappeared and the size of lung mass was decreased.

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A Case of Immunoglobulin G4-Related Sclerosing Disease Mimicking Lung Cancer

Cited by 2 publications

References 9 publications

A Case of IgG4-Related Lung Disease Presenting as Interstitial Lung Disease

A Case of IgG4-Related Lung Disease Presenting as Interstitial Lung Disease

IgG4-Related Lung Disease without Elevation of Serum IgG4 Level: A Case Report

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