A case of intrahepatic clear cell cholangiocarcinoma

Toriyama, Eo; Nanashima, Atsushi; Hayashi, Hideyuki; Abe, Kuniko; Kinoshita, N.; Yuge, Shunsuke; Nagayasu, Takeshi; Uetani, Masataka; Hayashi, Tomayoshi

doi:10.3748/wjg.v16.i20.2571

Cited by 16 publications

(18 citation statements)

References 16 publications

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“…Loss of CD10 has been previously reported in intrahepatic clear cell cholangiocarcinomas [12, 13]. Previously reported cases of intrahepatic clear cell bile duct adenoma were not evaluated with CD10 [2].…”

Section: Discussionmentioning

confidence: 99%

Cytopathologic, Histopathologic, and Immunohistochemical Features of Intrahepatic Clear Cell Bile Duct Adenoma: A Case Report and Review of the Literature

Lü

2014

Case Reports in Pathology

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Intrahepatic clear cell bile duct adenoma is extremely rare, with only 3 previous cases reported in the literature. The cause of cytoplasmic clearing in clear cell bile duct adenoma has not been previously investigated. Distinguishing clear cell bile duct adenoma from other clear cell tumors, particularly clear cell cholangiocarcinoma, can be challenging. Previous studies have shown loss of CD10 expression and focal CD56 expression in cholangiocarcinoma. Expressions of CD10 and CD56 have not been previously studied in clear cell bile duct adenoma. A 37-year-old morbidly obese woman was diagnosed with a 2.8 cm intrahepatic clear cell bile duct adenoma following segmental hepatic resection. Histochemical analysis of the tumor suggested the cause of cytoplasmic clearing in the neoplastic cells to be mucin and not glycogen or lipid. On immunohistochemical staining, the neoplastic cells demonstrated staining for CK7, CA 19-9, polyclonal CEA, CD10 (apical), CD56 (focal), and vimentin. Ki-67 highlighted less than 2% of tumor cell nuclei. This is the first report to study the etiology of cell clearing in clear cell bile duct adenoma. Expression of CD10 in clear cell bile duct adenoma may help distinguish clear cell bile duct adenoma from clear cell cholangiocarcinoma.

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Section: Discussionmentioning

confidence: 99%

Cytopathologic, Histopathologic, and Immunohistochemical Features of Intrahepatic Clear Cell Bile Duct Adenoma: A Case Report and Review of the Literature

Lü

2014

Case Reports in Pathology

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“…36,134 Importantly, RCCma is not specific for CC-RCC in this setting as it often is positive in HCCs with clear cell change. 135,136 Clear cell cholangiocarcinomas typically maintain a tubular architecture and are positive for CK7 and CK19, but negative for CD10 and PAX-8. 135,136 Clear cell cholangiocarcinomas typically maintain a tubular architecture and are positive for CK7 and CK19, but negative for CD10 and PAX-8.…”

Section: Livermentioning

confidence: 99%

The Use of Immunohistochemistry in the Diagnosis of Metastatic Clear Cell Renal Cell Carcinoma

Sangoi

Karamchandani

Kim

et al. 2010

Advances in Anatomic Pathology

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The diagnosis of metastatic clear cell renal cell carcinoma may be difficult in some cases, particularly in the small image-guided biopsies that are becoming more common. As targeted therapies for renal cell carcinoma are now standard treatment, the recognition and diagnosis of renal cell carcinoma has become even more critical. Many adjunctive immunohistochemical markers of renal epithelial lineage such as CD10 and RCCma have been proposed as aids in the diagnosis of metastatic renal cell carcinoma, but low specificities often limit their utility. More recently described markers (PAX-2, PAX-8, human kidney injury molecule-1, hepatocyte nuclear factor-1-β, and carbonic anhydrase-IX) offer the potential for greater sensitivity and specificity in this diagnostic setting; however, knowledge of their expected staining in other neoplasms and tissues is critical for appropriate use. In this review, we discuss the most widely used immunohistochemical markers of renal lineage with an emphasis on their sensitivity and specificity for metastatic clear cell renal cell carcinoma. Subsequently, we present a variety of organ-specific differential diagnostic scenarios in which metastatic clear cell renal cell carcinoma might be considered and we propose immunopanels for use in each situation.

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“…Histopathologically, ICC develops as various tissues form, such as well-differentiated adenocarcinoma, adenosquamous carcinoma, mucinous carcinoma, mucoepidermoid carcinoma, squamous carcinoma, sarcomatoid carcinoma, and signet-ring cell carcinoma [4,6]. Among them, the clear cell type is particularly rare.…”

Section: Discussionmentioning

confidence: 99%

“…We could distinguish clear cell ICC from clear cell HCC in terms of differences in the reactivities of HepPar-l, AFP, and Hepatocyto [4,9,[11][12][13][14]. Renal cell carcinoma is also a well-known clear cell tumor, and its immunohistochemical features include negativity for vimentin, CD10, and S-100 protein [4,[8][9][10][11]15]. Table 1 shows the cases of clear cell type ICC reported to date.…”

Section: Discussionmentioning

confidence: 99%

Intrahepatic cholangiocarcinoma with clear cell type following laparoscopic curative surgery

et al. 2020

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Background Intrahepatic cholangiocarcinoma (ICC) is the second most common malignancy of primary liver cancer. Among the several pathological types of ICC, only five cases of the clear cell type have been reported, including the one presented below. Here we report a unique case of clear cell type ICC following laparoscopic hepatectomy. Case presentation A 67-year-old woman had a history of hepatitis B virus. Computed tomography revealed a ring-like enhanced mass 35 mm in diameter at segment 7 in the early phase. The enhancement was prolonged to the late phase through the portal phase, while the shape was irregular. Ethoxybenzy magnetic resonance imaging revealed that the tumor had a low signal intensity on T1-weighted imaging and a high signal intensity on T2-weighted imaging. Diffusion-weighted images identified that the tumor had remarkably high signal intensity. Tumor enhancement was not detected throughout the tumor in the hepatocyte phase. Upon ICC diagnosis, a laparoscopic S7 subsegmentectomy was performed. The patient’s postoperative course was uneventful. An immunohistochemical examination revealed that the cells tested positive for cytokeratin 7 (CK7), CK19, and CD56 and negative for CK20, CD10, α-fetoprotein, thyroid transcription factor-1. At 2 years after surgery, the patient remains alive without recurrence. Conclusions Here we presented a case of clear cell ICC that was treated by laparoscopic hepatectomy. Immunological analysis, especially by CD56 and several CK markers, is helpful for diagnosing this disease.

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A case of intrahepatic clear cell cholangiocarcinoma

Cited by 16 publications

References 16 publications

Cytopathologic, Histopathologic, and Immunohistochemical Features of Intrahepatic Clear Cell Bile Duct Adenoma: A Case Report and Review of the Literature

Cytopathologic, Histopathologic, and Immunohistochemical Features of Intrahepatic Clear Cell Bile Duct Adenoma: A Case Report and Review of the Literature

The Use of Immunohistochemistry in the Diagnosis of Metastatic Clear Cell Renal Cell Carcinoma

Intrahepatic cholangiocarcinoma with clear cell type following laparoscopic curative surgery

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