A Case of Intraplacental Choriocarcinoma with Pulmonary Metastasis

Abstract

Intraplacental choriocarcinoma is a rare type of gestational choriocarcinoma occurring in the placenta, of which only a small number of cases have been reported. Gestational choriocarcinoma rapidly metastasizes to organs such as the lung, brain, and liver; thus, early diagnosis and treatment are essential. In addition, intraplacental choriocarcinoma can affect fetal mortality. We present a case of a 33-year-old woman diagnosed with intraplacental choriocarcinoma based on placental biopsy performed after the pregnancy had reached term. The patient had pulmonary metastasis at the time of diagnosis, but after the combination chemotherapy with EMA-EP, complete remission is maintained.

A Case of Pregnancy with Choriocarcinoma Complicated by a Cerebral Hemorrhage and Lung Metastasis

“…Early or low-risk patients can be treated with single-agent chemotherapy. Advanced, high-risk, and drug-resistant patients are mainly treated with combination chemotherapy, supplemented by local treatment [ 7 , 8 ]. If chemotherapy for liver or brain metastases or lesions with a diameter of >5 cm is not sufficient, surgery or radiotherapy should be performed as soon as possible [ 1 ].…”

Primary Hepatic Choriocarcinoma with Pregnancy: A Diagnostic and Therapeutic Challenge

“…2 The incidence decreases after a non-molar pregnancy. 3 Primary hepatic choriocarcinoma (PHC) involves the liver without a detectable lesion in the gonads, retroperitoneum, mediastinum, bladder, or prostate. 4 Only 11 cases of PHC have been reported in the English literature, but none of them are in a pregnant female.…”

Intraplacental choriocarcinoma in a term pregnancy: Is serial postpartum hCG assessment necessary?

“…Synonymously, choriocarcinoma in situ has been used to describe neoplastic trophoblast proliferations that are restricted to the placenta without metastases ( Trask et al, 1994 ). Disease presentation can range from asymptomatic with incidental findings of IC on placental pathology to metastatic maternal and infantile disease ( Jiao et al, 2016 , Caldas et al, 2017 , Lele et al, 1999 , Kanehira et al, 2013 , Trask et al, 1994 , Medeiros et al, 2008 , Liu and Guo, 2006 , Christopherson et al, 1992 , Duleba et al, 1992 , Sauvestre, 2014 , Aonahata et al, 1998 , Jacques et al, 1998 , Lee and Cho, 2019 , Sebire et al, 2005 ). Most cases present with no evidence of disseminated disease and are monitored with serial beta human chorionic gonadotropin (hCG) levels ( Jiao et al, 2016 , Caldas et al, 2017 , Lele et al, 1999 , Jacques et al, 1998 ).…”