A case of intravascular large B-cell lymphoma of lung presenting with progressive multiple nodules on chest computed tomography

Abstract

A 71-year-old man was admitted to our hospital for dyspnea, which had worsened over a period of more than six months. He was previously diagnosed as having cryptogenic organizing pneumonia, and was treated with steroids in another hospital. He had complained of worsening dyspnea, despite the treatment. We performed video-assisted thoracoscopic surgery because of the high level of lactate dehydrogenase and inconsistency of the usual interstitial pneumonia pattern. Pathologic specimens showed atypical lymphocytes confined to the pulmonary capillaries. On immunohistochemical staining, tumor cells were found positive for CD20, without the T-cell marker. It was consistent with findings of intravascular large B-cell lymphoma. We report this case, which presented with progressive multiple nodules on chest computed tomography.

A case of lung intravascular large B cell lymphoma developed with respiratory failure rescued by corticosteroid prior to definite diagnosis

“…It is known to be useful to diagnose lung IVL by transbronchial lung biopsy [ 3 , [8] , [9] , [10] ], but others reported that TBLB could not be performed because of hypoxemia during examination [ 11 ]. Since lung primary or predominant form of IVLBCL has poor prognosis [ 12 , 13 ], early diagnosis is needed.…”

Primary lung intravascular large B-Cell lymphoma clinically mimicking sarcoidosis: A rare case report and review of literature

“…Definitive diagnosis needs to be established by histopathological examination. Radiological presentation of IVBCL on CT scan of the chest can be nonspecific, ranging from normal, ground glass, to solitary or diffuse multiple small nodules [[8], [9], [10],16]. Tissue biopsies such as surgical lung biopsy, random transbronchial lung biopsy, CT guided percutaneous lung biopsy, skin biopsy, percutaneous renal biopsy are among the different modalities documented to have been used to obtain a pathological diagnosis of IVBCL with pulmonary presentation [8].…”

Intravascular large B-cell lymphoma in Hispanics: a case series and literature review

“…Radiological imaging plays a little role in diagnosis of IVLBCL with absence of lymphadenopathy as in our cases [ 12 , 13 ]. Imaging of the abdomen frequently showed splenomegaly, which was also found in two of our three patients.…”