A 28-year-old male visited our hospital complaining of mild abdominal pain and nausea since the previous day. CT revealed intussusception of the ascending colon into the transverse colon without findings of peritonitis or perforation. Emergency laparoscopic ileocecal resection was performed with the intent to release intussusception. However, reduction of intussusception under laparoscopy was an arduous procedure. During the operation, numerous soft polypoid masses in the colonic submucosa were observed, and a diagnosis of pneumatosis cystoides intestinalis (PCI) was made. The affected portion of the colon was removed during ileocecal resection. Analysis of the resected specimen revealed PCI as the possible cause of intussusception. The postoperative course was uneventful and the patient was discharged on the 7th postoperative day. If diagnosed early based on typical radiographic (CT) features, PCI can be conservatively managed with treatment options including oxygen therapy. For cases requiring surgical treatment, laparoscopic surgery is recommended since this allows radical cure with minimal invasiveness, which permits early rehabilitation and return to normal life.