A Case of Invasive Penicilliosis in Hong Kong with Immunologic Evaluation

So, S. Y.; CHAU, Patrick; Jones, Brian M.; Wu, P. C.; Pun, Kong-Pang; Lam, Wah‐Kit; Lawton, J. W. M.

doi:10.1164/arrd.1985.131.4.662

Cited by 53 publications

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“…The first reported case of human infection was produced by accidental inoculation of the finger (Segretain 1959). Most of the reported cases of natural infection have occurred in orientals (Jayanetra et al 1984, Deng & Connor 1985, So et al 1985, and it had been suggested that the disease might be endemic in Southeast Asia. The infection is more common in males than females, over a wide age range.…”

Section: Discussionmentioning

confidence: 99%

“…Penicillium marneffei is a dimorphic fungus that may infect either immunocompromised or previously healthy subjects (Chandler, Kaplan & Ajello 1980, Jayanetra et al 1984, Deng & Connor 1985. Though most of the reported cases are from Asia (Jayanetra et al 1984, Deng & Connor 1985, So et al 1985, the disease can occur in or be imported into any country (DiSalvo, Fickling & Ajello 1973, Pautler, Padhye & Ajello 1984. Recognition of this rare disease is important because it is potentially treatable by chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

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Penicillium marneffei infection: an underdiagnosed disease?

et al. 1988

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Penicillium marneffei is a rare human pathogen that often causes problems in clinical and histological diagnosis. A patient who presented with autoimmune haemolytic anaemia and hepatosplenomegaly, and was subsequently found to be suffering from disseminated Penicillium marneffei infection, is reported. The liver biopsy showed epithelioid cell granulomas only, and tuberculosis was initially considered the most likely diagnosis. The correct diagnosis became evident in a subsequent colonic biopsy, which showed extensive infiltration by penicillium-laden macrophages.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Penicillium marneffei infection: an underdiagnosed disease?

et al. 1988

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“…and other bacteria were negative. In the skin biopsy specimen, yeast forms of P. marneffei (2)(3)(4)(5)(6)(7)(8) fim in diameter) were demonstrated in both intra-and extra-cellular location in a granulomatous infiltrate which extended throughout the dermis and the subcutis. A few Langhans giant cells and eosinophils were also present.…”

Section: Case Reportmentioning

confidence: 99%

Disseminated Penicillium marneffei infection with cutaneous lesions in an HIV-positive patient

Liu

Wong

Fung

2006

British Journal of Dermatology

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“…marneffei has its recognized ecological niche restricted to Southeast Asia and the Far East. In Hong Kong, the first two cases of P. marneffei infection in patients with AIDS were reported in 1991 but previously published accounts of such infection involved only patients who were not infected with HIV (So et al, 1985;Yuen et al, 1986;Tsang et al, 1988;Chan et al, 1989Chan et al, , 1990. In Taiwan, six cases were identified between 1987 and 1996: three were AIDS patients with a mean CD4 lymphocyte count of 10/L, and three were non-HIV infected patients who received immunosuppressive therapy at the onset of infection.…”

Section: Epidemiological Characteristicsmentioning

confidence: 99%

“…The first natural infection in humans was reported in 1973 in a 61-year-old American missionary with Hodgkin's disease, who had been living in Southeast Asia (DiSalvo et al, 1973). During 1974During -1988, only 20 cases with P. marneffei infection were reported: in one American who had travelled in the Far East (Pautler et al, 1984), in one Chinese man in Hong Kong (So et al, 1985), in five Thai patients (Jayanetra et al, 1984), and in 11 Chinese adults and two Chinese infants in Southern China (Deng et al, 1988). The cases of disseminated P. marneffei infection in HIV-infected patients were first reported in 1988 (Piehl et al, 1988;Peto et al, 1988).…”

Section: Introductionmentioning

confidence: 99%

Penicilliosis marneffei: another AIDS defining illness in Southeast Asia

Nittayananta

1999

Oral Diseases

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Penicilliosis marneffei, a common mycosis among AIDS patients living in Southeast Asia, has been recently suggested for inclusion in the AIDS surveillance case definition. Infections with Penicillium marneffei were rare in the past, but infections with this dimorphic fungus have increased with the endemic of AIDS in the region. The reservoir of P. marneffei in nature is still unknown, although it seems likely that inhalation may be the route of entry of the organism leading to infection in humans. P. marneffei can cause two clinical types of the disease; focal and fatal progressive, disseminated infections, characterized by a variety of symptoms which can mimic those of other diseases. Oral P. marneffei lesions usually occur in patients with disseminated infections, presenting as shiny papules, as erosions or as shallow ulcers covered with whitish yellow, necrotic slough which may be found on the palate, gingiva, labial mucosa, tongue and oropharynx. Biopsy and culture provide definitive diagnoses, while serologic tests for both antibody and antigen are useful in rapid presumptive diagnoses as well as in surveillance studies of the prevalence and latency of the infection. Penicilliosis marneffei is a treatable disease, but late diagnosis and treatment may be fatal. Itraconazole and ketoconazole are the drugs of first choice for mild to moderately severe forms of the disease, whereas parenteral therapy with amphotericin B may be required for seriously ill patients. Recurrence of the disease is common, therefore maintenance is recommended. As reported, prophylaxis generating resistant strains are likely to develop.

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A Case of Invasive Penicilliosis in Hong Kong with Immunologic Evaluation

Cited by 53 publications

References 0 publications

Penicillium marneffei infection: an underdiagnosed disease?

Penicillium marneffei infection: an underdiagnosed disease?

Disseminated Penicillium marneffei infection with cutaneous lesions in an HIV-positive patient

Penicilliosis marneffei: another AIDS defining illness in Southeast Asia

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