A case of jejunal solitary Peutz–Jeghers polyp with intussusception identified by double-balloon enteroscopy

Endo, Katsuya; Kawamura, Keita; Murakami, Kazuhiro; Murakami, Keigo; Nagao, Munenori; Satoh, Tomonori; Takasu, Atsuko; Kogure, Takayuki; Hirota, Morihisa; Meguro, Takayoshi; Shibata, Chikashi; Satoh, Kennichi

doi:10.1007/s12328-020-01197-2

Cited by 8 publications

(5 citation statements)

References 36 publications

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“…From a literature review and analysis of 93 cases of solitary Peutz-Jeghers type polyp from the MEDLINE database between 2000 and 2020, Endo et al reported the most frequently involved site was sigmoid colon (31.2%), followed by duodenum (24.7%), rectum (14.0%), jejunum (7.5%) and stomach (7.5%), in contrary to Peutz-Jeghers syndrome, of which the polyps most commonly occur in the small bowel. 9 Solitary Peutz-Jeghers type polyp is histologically identical to the polyps in Peutz-Jeghers syndrome, however, molecularly it seems to be a different entity. STK11/LKB1 is a tumor suppressor gene located on Chromosome 19, and variants of pathological STK11/LKB1 predispose to Peutz-Jeghers syndrome.…”

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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Solitary Peutz-Jeghers Type Polyp of Jejunum with Gastric Fundic and Antral Gland Lining Mucosa: A Case Report and Review of Literature

et al. 2021

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Solitary Peutz-Jeghers type polyps are characterized by a hamartomatous polyp of the gastrointestinal (GI) tract in a patient without mucocutaneous pigmentation, family history of Peutz-Jeghers syndrome, or STK11/LKB1 mutations. Histologically identical to the polyps in Peutz-Jeghers syndrome, these sporadic polyps can arise anywhere along the GI tract, with typical arborizing smooth muscles extending from the muscularis mucosa. While the lining mucosa is generally the same as the organ in which it arises, gastric pyloric and osseous metaplasia have been reported in intestinal polyps in Peutz-Jeghers syndrome. Herein, the authors report the first case of a small intestinal solitary Peutz-Jeghers type polyp with gastric antral and fundic gland lining mucosa. A 43-year-old male was admitted for small bowel obstruction. Diagnostic laparoscopy revealed jejuno-jejunal intussusception with an associated polyp measuring 7.2 cm. Histological examination showed a hamartomatous polyp with arborizing smooth muscle bundles extending from the muscularis mucosae. The polyp was lined by non-dysplastic gastric antral and fundic gland mucosa, and was sharply demarcated from the adjacent non-polypoid intestinal mucosa. Colonoscopy, esophagogastroduodenoscopy and small bowel enteroscopy revealed no additional polyps or masses. Thorough investigation of the patient's family history was negative for Peutz-Jeghers syndrome or mucocutaneous pigmentation. Molecular analysis of the lesion was negative for STK11/LKB1 mutations. A diagnosis of solitary Peutz-Jeghers type polyp of the small bowel with gastric antral and fundic gland mucosal lining was rendered.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Solitary Peutz-Jeghers Type Polyp of Jejunum with Gastric Fundic and Antral Gland Lining Mucosa: A Case Report and Review of Literature

et al. 2021

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“…Furthermore, the frequently involved site is quite different. The polyp of the syndrome mostly occurs in small intestine, whereas the solitary counterpart develops mostly in sigmoid colon, followed by duodenum, rectum, jejunum, and stomach, according to the previously published literatures [ 2 , 3 ].…”

Section: Discussionmentioning

confidence: 98%

Solitary Peutz-Jeghers type harmartomatous polyp in duodenum with gastric foveolar epithelium: a case report

Choi

Lee

Park

2023

JPTM

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Peutz-Jeghers type hamartomatous polyp is known to be associated with Peutz-Jeghers syndrome, which shows characteristic multiple hamartomatous polyp involvement in the gastrointestinal tract, combined with mucocutaneous symptom, familial history of Peutz-Jeghers syndrome or STK11/LTB1 mutation. However, some cases showing histologic appearance of the polyps discovered in Peutz-Jeghers syndrome while lacking other diagnostic criteria of the syndrome have been reported, and these are called solitary Peutz-Jeghers type polyps. Herein, we report a case of solitary Peutz-Jeghers type polyp covered with heterotopic epithelium. The patient was 47-year-old female without any mucocutaneous symptoms nor familial history of Peutz-Jeghers syndrome. Microscopic examination revealed Peutz-Jeghers type hamartomatous polyp in duodenum covered with gastric type foveolar epithelium. Considering the definition of hamartomatous polyp, which is, the abnormal overgrowth of the indigenous epithelial component, the histological feature of current case is noteworthy in a point that it shows proliferation of heterotopic component, rather than the indigenous component.

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“…Solitary Peutz–Jeghers polyp is defined as a hamartomatous polyp, having similar histopathological findings to the polyps found in Peutz–Jeghers syndrome, in patients without a family history or mucocutaneous pigmentation 1 . Solitary Peutz–Jeghers polyp is rare, especially in the jejunum, and can cause gastrointestinal bleeding and intussusception 2 3 . Most jejunal cases have been treated with surgery and only a few cases have been endoscopically resected 2 4 .…”

Section: Figmentioning

confidence: 99%

Double-balloon enteroscopy-assisted polypectomy for a solitary jejunal Peutz–Jeghers polyp causing anemia

et al. 2022

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A case of jejunal solitary Peutz–Jeghers polyp with intussusception identified by double-balloon enteroscopy

Cited by 8 publications

References 36 publications

Solitary Peutz-Jeghers Type Polyp of Jejunum with Gastric Fundic and Antral Gland Lining Mucosa: A Case Report and Review of Literature

Solitary Peutz-Jeghers Type Polyp of Jejunum with Gastric Fundic and Antral Gland Lining Mucosa: A Case Report and Review of Literature

Solitary Peutz-Jeghers type harmartomatous polyp in duodenum with gastric foveolar epithelium: a case report

Double-balloon enteroscopy-assisted polypectomy for a solitary jejunal Peutz–Jeghers polyp causing anemia

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