A Case of Late Kidney Allograft Failure

Randhawa, Parmjeet; Mannon, Roslyn B.

doi:10.2215/cjn.04920512

Cited by 4 publications

(4 citation statements)

References 37 publications

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“…There have been many individual case reports of ADV nephritis . Pathological findings of ADV nephritis are characterized by widespread interstitial mononuclear inflammation, which is difficult to distinguish from acute T‐cell‐mediated rejection (Fig.…”

Section: Adv Infection In Kidney Transplant Patientsmentioning

confidence: 99%

“…Renal tubules show tubulitis accompanied by tubular destruction, necrosis and viral cytopathic effects, including nuclear enlargement, peripheral condensed chromatin and basophilic nuclear inclusions representing viral particles . There are some reports that show ADV‐infected cells by in situ hybridization or immunohistochemical staining, but unfortunately, there is no commercial antibody with high reliability for ADV staining. Under electron microscopy, 70–80 nm viral particles are visible within the tubular epithelial cells …”

Section: Adv Infection In Kidney Transplant Patientsmentioning

confidence: 99%

“…There are some reports that show ADV‐infected cells by in situ hybridization or immunohistochemical staining, but unfortunately, there is no commercial antibody with high reliability for ADV staining. Under electron microscopy, 70–80 nm viral particles are visible within the tubular epithelial cells …”

Section: Adv Infection In Kidney Transplant Patientsmentioning

confidence: 99%

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Viral infections directly involved in kidney allograft function

Masutani

2018

Nephrology

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Modern immunosuppressive therapy has dramatically reduced the incidence of acute rejection and improved graft survival in kidney transplant patients. However, infectious complications remain an important issue. Amongst the various pathogens, viruses such as adenovirus and polyomavirus BK can directly cause acute or chronic graft dysfunction. Adenovirus mainly causes haemorrhagic cystitis and tubulointerstitial nephritis in kidney transplant patients. While patients show apparent clinical symptoms such as fever, dysuria, gross haematuria, frequency and urgency of urination, and most patients show acute graft dysfunction, these symptoms and graft dysfunction are reversible. Polyomavirus BK infection, however, is asymptomatic but graft outcome is poor if the patient develops tissue-invasive nephropathy confirmed by graft biopsy. Recently, an attempt to create a pathological classification for predicting the clinical course has been made by the Banff Working Group on Polyomavirus Nephropathy. With regards to treatment, the basic strategy is a reduction of calcineurin inhibitor and/or antimetabolites, and the effectiveness of several adjunct treatments has been investigated in several clinical trials. There are other unresolved issues, such as the diagnosis of subsequent acute rejection, the definition of remission, methods of resuming immunosuppression and long-term follow-up. Most of all, development of effective vaccines and novel drug discovery are necessary to prevent the development and progression of BKV-associated nephropathy.

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Section: Adv Infection In Kidney Transplant Patientsmentioning

confidence: 99%

Section: Adv Infection In Kidney Transplant Patientsmentioning

confidence: 99%

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Viral infections directly involved in kidney allograft function

Masutani

2018

Nephrology

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“…Среди типичных оппортунистических инфекций, поражающих почечный трансплантат непосредственно либо как часть системного процесса, следует отметить полиомавирусы, аденовирусы и семейство герпесвирусов, включая Herpes simplex 1-го и 2-го типа (HSV-1 и HSV-2), цитомегаловирус (CMV) и вирус Эпштейна-Барр (EBV) [1,3,6,[11][12][13][14][15][16].…”

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Morphological diagnosis of viral damage to a kidney transplant

2016

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Due to the development of organ transplantation and its accompanying immunosuppression, recent years have been marked by the higher incidence of opportunistic viral infections that are of considerable importance among posttransplantation complications. A variety of viral infections, the possibility of their concomitant or subtle course, and the ability to cause life-threatening complications in recipients make relevant the description of existing diagnostic methods. The article summarizes the data available in the literature on the etiology, clinical symptoms, and morphological manifestations of viral infections, such as polyomaviruses, adenoviruses, herpesviruses, including HSV-1, HSV-2, cytomegalovirus (CMV), and Epstein-Barr virus. It describes the principles of differential diagnosis of kidney transplant damage caused by these viruses and that with acute cellular and humoral rejection, which plays an important role due to opposite approaches to treating these diseases.

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Malignancies After Transplantation and Posttransplant Lymphoproliferative Disorder

Kamal

Mannon

2014

Kidney Transplantation

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A Case of Late Kidney Allograft Failure

Cited by 4 publications

References 37 publications

Viral infections directly involved in kidney allograft function

Viral infections directly involved in kidney allograft function

Morphological diagnosis of viral damage to a kidney transplant

Malignancies After Transplantation and Posttransplant Lymphoproliferative Disorder

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