A case of leishmaniasis with a lupus-like presentation

Çakar, Mustafa; Çınar, Muhammet; Yılmaz, Sedat; Sayın, Selim; Ozgur, Gokhan; Pay, Salih

doi:10.1016/j.semarthrit.2015.04.001

Cited by 2 publications

(3 citation statements)

References 4 publications

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“… 7 There are also frequent reports of VL presenting as an autoimmune disease mimicking autoimmune hepatitis, primary biliary cirrhosis, rheumatoid arthritis and systemic lupus erythematosus. 8 , 9 Higher rates of morbidity and mortality are consequences of the delay in diagnosis. 10 , 11 , 12 VL is also reported to be one of the most common causes of fever of unknown origin causing troublesome diagnosis in a European low-income country.…”

Section: Introductionmentioning

confidence: 99%

Hematological Characteristics of Yemeni Adults and Children With Visceral Leishmaniasis. Could Eosinopenia Be a Suspicion Index?

Al-Ghazaly

Al-Dubai

Abdullah

et al. 2017

Mediterr J Hematol Infect Dis

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Background and objectivesDelay in the diagnosis of visceral leishmaniasis (VL) particularly in non-endemic areas is associated with higher mortality. In our experience, we found that marked bone marrow eosinopenia was a very frequent accompaniment of VL and might be a useful clue for the diagnosis, which indicates the opportunity for further morphological assessment. The aim of this study was to describe the hematological characteristics including peripheral blood and bone marrow findings of Yemeni adults and children with VL.MethodsWe conducted a descriptive analytic study to evaluate systematically peripheral blood and bone marrow findings of Yemeni adults and children with VL. Peripheral blood and bone marrow aspiration of patients with bone marrow aspirate confirmed VL were examined. Forty-seven patients with the main age (±SD) of 17.34±11.37 years (Range: 1–60) were included in the study. Fifty-one non-VL subjects with splenomegaly and pancytopenia or bicytopenia served as control group.ResultsAll patients with VL had anemia, 41 (87%) leukopenia, 42 (89%) neutropenia, 44 (94%) thrombocytopenia, 42 (89%) eosinopenia, 34 (72%) pancytopenia and 13 (28%) had bicytopenia. In bone marrow examination 40 (85%) showed hypercellularity, 44 (94%) eosinopenia, 24 (51%) dyserythropoiesis, 22 (47%) lymphocytosis, 8 (17%) plasmacytosis, 27 (57%) decreased iron stores and 20 (43%) showed decreased sideroblasts. Comparison of VL patients with the control group showed significantly more frequent peripheral blood eosinopenia and lymphopenia and marrow eosinopenia. There was no significant difference between adults and children in any of the hematological features.ConclusionAnemia, leukopenia, neutropenia, thrombocytopenia, eosinopenia, pancytopenia and marked bone marrow eosinopenia were the most common findings. The finding of marked bone marrow eosinopenia is a significant clue for the diagnosis of visceral leishmaniasis in patients who present with splenomegaly associated with cytopenias. This finding is particularly valuable in non-endemic areas.

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Section: Introductionmentioning

confidence: 99%

Hematological Characteristics of Yemeni Adults and Children With Visceral Leishmaniasis. Could Eosinopenia Be a Suspicion Index?

Al-Ghazaly

Al-Dubai

Abdullah

et al. 2017

Mediterr J Hematol Infect Dis

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“…In the systematic literature review by Santana et al reported in 2015, there were 10 cases in which SLE and VL coexisted and mimicked SLE exacerbation, and 18 cases in which VL led to false suspicion of SLE. The only case from Turkey in this review is a VL case mimicking SLE by Tunccan et al 1,11 In our literature review, we found several more case reports, one from Turkey (the second case reported from Turkey is also a VL case mimicking SLE) 12–15 . In other words, although Turkey is among the endemic countries for leishmaniasis, the case presented here is the first reported case of VL in a lupus patient in Turkey.…”

Section: Discussionmentioning

confidence: 48%

“…case from Turkey in this review is a VL case mimicking SLE by Tunccan et al 1,11 In our literature review, we found several more case reports, one from Turkey (the second case reported from Turkey is also a VL case mimicking SLE). [12][13][14][15] In other words, although Turkey is among the endemic countries for leishmaniasis, the case presented here is the first reported case of VL in a lupus patient in Turkey.…”

Section: Ta B L E 2 Laboratory Parameters and Treatment Of The Patien...mentioning

confidence: 97%

Visceral leishmaniasis in a patient with systemic lupus erythematosus: Dilemma in diagnosis and management

et al. 2022

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Patients with systemic lupus erythemasus (SLE) have an increased risk of bacterial, viral, fungal or parasitic infections, especially if they are receiving immunosuppressive therapy. Leishmaniasis is a group of diseases caused by intracellular flagellate protozoan parasites belonging to the genus Leishmania. We present a 48‐year‐old female patient, diagnosed with SLE many years ago, who presented with high fever and pancytopenia. We thought that the patient's hematologic findings were related to SLE hematologic involvement. However, we investigated other possible causes when there was no response to drugs for the treatment of SLE. A second bone marrow biopsy showed Leishmania amastigotes and the patient was diagnosed with leishmaniasis. The patient was treated with liposomal amphotericin‐B (treatment completed at 40 days). She showed rapid clinical improvement and showed no signs of disease after 4 months.

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A case of leishmaniasis with a lupus-like presentation

Cited by 2 publications

References 4 publications

Hematological Characteristics of Yemeni Adults and Children With Visceral Leishmaniasis. Could Eosinopenia Be a Suspicion Index?

Hematological Characteristics of Yemeni Adults and Children With Visceral Leishmaniasis. Could Eosinopenia Be a Suspicion Index?

Visceral leishmaniasis in a patient with systemic lupus erythematosus: Dilemma in diagnosis and management

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