A case of leprosy in Malawi. Making the final push towards eradication: a clinical and public health perspective

Roe, Cieron; May, Lucy

doi:10.1186/s40249-016-0176-z

“…As the study reveals nine in 10 peoples earn less than $1/day which indicates the possibility of the association of leprosy and poverty in Ethiopia. Although it is very difficult to demonstrate the link between poverty and leprosy at community or individual level, several epidemiological studies have consistently reported the strong association between leprosy and poverty at community and household level in Indonesia [13] in Bangladesh [14], in Malawi [15] and in India [16].…”

Section: Discussionmentioning

confidence: 99%

Knowledge and self-care practice of leprosy patients at ALERT Hospital, Ethiopia

Girma

¹

,

Bobosha

²

,

Hailu

³

et al. 2018

Preprint

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Background Leprosy is a chronic infectious disease of public health importance and one of the leading causes of permanent physical disability. The integration of leprosy service to the general health system in Ethiopia made leprosy patients to be seen by non-leprosy specialists which could lead to misdiagnosis and delay in treatment. In addition to the multi-drug treatment, patient self - care practice is crucial for the successful treatment of the disease. This study was aimed to assess the knowledge and self-care practices of leprosy patients and associated factors at ALERT leprosy referral Hospital in Ethiopia. Method A cross-sectional study was conducted ALERT leprosy referral Hospital, Addis Ababa, Ethiopia. A total of 424 leprosy patients were interviewed using pre-tested structured questionnaires. The questionnaires included core points such as socio-demographic characteristics, knowledge of leprosy and self-care practices. Bloom’s cut off point was used to describe the knowledge and self-care practice of the respondents and statistical significance was assessed at 95% confidence interval with 5% of level of significance. Result The knowledge score of the respondents was poor for 276 (65.1%) and good for 148 (34.9%). The level of knowledge was significantly varied within age groups (P= 000), sex (P=000), marital status (p=0.003), educational status (p=000) and income (p-000). More than three-fourth (77.4%) of interviewed patients had poor self-care practice and only less than a quarter (22.6%) of patients had good self-care practice score (P=000). Age (p=0.002), Previous disability due to leprosy (P=000), Knowledge of leprosy (p=0.038) and income (P=0.028) significantly associated with poor self-care practice. On the other hand, educational status, sex, marital status and health education did not associated with leprosy self-care practice. Conclusion Although, leprosy treatment, disability prevention and rehabilitation program run in the country under general public health care service for decades, poor leprosy self-care practice and poor leprosy knowledge had been confirmed in this study. Therefore, the leprosy service program should re-visit its strategy and mode of delivery to improve the leprosy knowledge and leprosy self-care practices of patients. Author summary Leprosy is an infectious bacterial disease. It is a curable disease if treated early before disability occurs with the correct regimen. However, treatment cannot reverse disability once occurred. in addition to chemotherapeutic treatment, lack of social and psychological treatment may expose patients to disability as they may not adhere to treatment. To prevent disability it is vital to empower leprosy patients through promoting self-confidence, providing knowledge and self-care skills. In the present study, we investigated the knowledge and self-care practice of 424 leprosy patients at ALERT hospital through face-to face guided interview. It was found that majority of patients had poor knowledge about leprosy. Some factors such as sex, income status, age and educational status of the patient significantly affected the level of leprosy knowledge. Similarly, it was found that 77% of patients had poor self-care practice which significantly varied with income status, knowledge of leprosy, age and having previous disability. Therefore, it is very important to improve the leprosy knowledge and self-care skills of patients. This can be achieved through dealing with issues such as the physical, emotional, intellectual and social aspects of the patients in addition to the chemotherapeutic treatment.

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“…Pericytes are identifiable by a multitude of molecular markers, including neural-glial antigen 2 (NG2), beta-type platelet-derived growth factor receptor (PDGFRβ), CD146, G protein signaling 5 (RGS5), nestin, α-SMA, desmin, CD13, and alkaline phosphatase (AP) [ 46 , 115 , 116 ]. However, employing multiple markers remains essential as these markers are not exclusive to pericytes, and their use is needed to purify pericyte populations from specific organs [ 117 , 118 ]. Within skeletal muscles, pericytes are dividable into two primary subtypes based on the cellular marker expression: type I (PDGFRβ + NG2 + CD146 + and Nestin − ) and type II (PDGFRβ + NG2 + CD146 + and Nestin + ) [ 119 ].…”

Section: Pericytesmentioning

confidence: 99%

MuSCs and IPCs: roles in skeletal muscle homeostasis, aging and injury

Jiang,

Liu,

Lin

et al. 2024

Cell. Mol. Life Sci.

2

0

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Skeletal muscle is a highly specialized tissue composed of myofibres that performs crucial functions in movement and metabolism. In response to external stimuli and injuries, a range of stem/progenitor cells, with muscle stem cells or satellite cells (MuSCs) being the predominant cell type, are rapidly activated to repair and regenerate skeletal muscle within weeks. Under normal conditions, MuSCs remain in a quiescent state, but become proliferative and differentiate into new myofibres in response to injury. In addition to MuSCs, some interstitial progenitor cells (IPCs) such as fibro-adipogenic progenitors (FAPs), pericytes, interstitial stem cells expressing PW1 and negative for Pax7 (PICs), muscle side population cells (SPCs), CD133-positive cells and Twist2-positive cells have been identified as playing direct or indirect roles in regenerating muscle tissue. Here, we highlight the heterogeneity, molecular markers, and functional properties of these interstitial progenitor cells, and explore the role of muscle stem/progenitor cells in skeletal muscle homeostasis, aging, and muscle-related diseases. This review provides critical insights for future stem cell therapies aimed at treating muscle-related diseases.

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“…A instituição de EPS para profissionais, em especial da atenção primária, para a prevenção e controle da hanseníase, se constitui num potencializador do processo de trabalho em saúde, viabilizando ações eficazes na abordagem da hanseníase, desde o diagnóstico até a implementação de ações educativas, favorecendo a quebra da cadeia de transmissão, o autocuidado, a adesão ao tratamento, consequentemente, prevenindo complicações [15][16][17][18][19][20][21][22][23][24][25][26][27][28] Biopolítica, vigilância de contatos e inclusão da família: desafios ao processo educativo…”

Section: Produção De Conhecimento E Gerenciamento Do Processo De Trab...unclassified

Afetos e afecções na formação de conhecimento sobre a hanseníase: contribuições para prática educativa em saúde

Silva Silveira,

Amorim de Souza,

Da Silva Ferreira

et al. 2024

Saúde Redes

0

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O artigo faz uma reflexão sobre a relação entre o conhecimento formado sobre a hanseníase com a teoria dos afetos do filósofo Benedictus de Spinoza, utilizando o referencial cartográfico de Deleuze e Guattarri, enquanto modo de produção de conhecimento. O objetivo foi apreender os afetos e afecções envolvidos na formação de conhecimento sobre a hanseníase, na vivência dos acometidos. A pesquisa, qualitativa, foi realizada em um Centro de Referência em Hanseníase de uma cidade de médio porte do nordeste brasileiro, com informantes cadastrados em tal Centro. Para a produção dos dados, realizou-se entrevista semiestruturada e observação participante. Os dados foram analisados a partir da triangulação de dados. Os resultados apontaram para uma fragilidade no diagnóstico da hanseníase e que o uso de tecnologias mais relacionais no processo de trabalho em saúde, a percepção das singularidades, a inclusão da família, a viabilização de experimentações e a demarcação de fatores de motivação individuais, são vitais ao processo educativo. Conclui-se que, no planejamento das atividades educativas, devem ser levados em consideração as singularidades dos indivíduos alvo das ações. Além disso, a formação do conhecimento não se dá, exclusivamente, pelo contato com o profissional e nem se restringe ao conhecimento técnico e biologicista da doença. Assim, pensar um processo educativo que cumpra seu propósito transformador requer do profissional muito mais que conhecimento técnico-científico sobre a doença. Palavras-chave: Educação continuada; Educação em Saúde; Hanseníase.

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A case of leprosy in Malawi. Making the final push towards eradication: a clinical and public health perspective

Cited by 5 publications

References 9 publications

Knowledge and self-care practice of leprosy patients at ALERT Hospital, Ethiopia

Knowledge and self-care practice of leprosy patients at ALERT Hospital, Ethiopia

MuSCs and IPCs: roles in skeletal muscle homeostasis, aging and injury

Afetos e afecções na formação de conhecimento sobre a hanseníase: contribuições para prática educativa em saúde

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