A Case of Leukocytoclastic Vasculitis Caused by<i>Listeria monocytogenes</i>Bacteremia

Bunker, Daniel; Sullivan, Timothy

doi:10.1155/2016/1093453

Cited by 4 publications

(10 citation statements)

References 16 publications

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“…Vasculitis is any inflammatory vessel disease that is definitively diagnosed on biopsy. A maculopapular rash is a heralding sign, and rash was noted first in all of our cases, and in one other documented report of LVAD vasculitis ( 3 ). LCV is a small-vessel vasculitis defined as neutrophilic inflammation, which results from immune complex deposition (type III reaction, Figure 1 ) and can be idiopathic or caused by other systemic vasculitides, connective tissue diseases, malignancy, paraprotein disorders, infections, or medications.…”

Section: Discussionsupporting

confidence: 64%

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LVAD Vasculitis Case Series

et al. 2021

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Section: Discussionsupporting

confidence: 64%

“…In all noted LVAD cases with LCV ( 3 ), acute gram-positive infection was the determined cause. C.jeikeium is known to be a multidrug resistant organism that may cause various infections ( 8 ).…”

Section: Discussionmentioning

confidence: 99%

LVAD Vasculitis Case Series

et al. 2021

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“…IgA vasculitis has been reported to occur in association with various bacteria, including Clostridium difficile and Mycoplasma pneumoniae . Aerococcus viridians , Listeria monocytogenes , Ureaplasma urealyticum and Burkholderia cepacia have been incriminated in cutaneous LCV. Infectious aortitis can be caused by Treponema pallidum , Staphylococcus aureus , Salmonella spp., Streptococcus pneumonie and Mycobacterium tuberculosis .…”

Section: Microbiologymentioning

confidence: 99%

“…Management of the infection‐associated vasculitides involves education of the patient and the family, local treatment of the affected organs or structures, supportive systemic treatment, specific antimicrobial treatment when available, and occasionally immunosuppressive therapy, as appropriate. In the majority of instances, timely institution of the specific antimicrobial therapy (Table ) saves the organ or even sometimes life . Thus early diagnosis is the key to success.…”

Section: Managementmentioning

confidence: 99%

Infection‐associated vasculitides

Haq

Pagnoux

2018

Int J of Rheum Dis

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Vasculitides are disorders characterized by inflammation of the vessel walls, often caused by autoimmunity, but sometimes as a result of microbial invasion. Almost all types of microbes including bacteria, viruses, protozoa and fungi have been incriminated in the pathogenesis of vasculitis. Accurate etiological diagnosis is important since immunosuppressive treatment may lead to further deterioration if infection is the cause of vasculitis. Clinical features sometimes provide clues to the etiology. Further evaluation requires a focused and cost-effective plan of laboratory investigation. The investigations aim at establishing the diagnosis of vasculitis and identify the causative organism. An accurate diagnosis of vasculitis optimally requires histological examination and imaging. For infection-associated vasculitis, the identification of the organism requires studies of stained specimens, cultures, and/or detection of antigens and antibodies. Ideally, the treatment involves administration of an appropriate antimicrobial. In non-self-limiting types of vasculitides, glucocorticoids are needed when the symptoms are progressive, with vital organs involvement, and sometimes, when there is no antimicrobial agent of proven efficacy against the incriminated agent. Additional immunosuppressive agents or interventions must be considered when the disease is severe and/or post-infective immune mechanisms are involved in the pathogenesis, e.g., severe HBV-or HCV-associated vasculitides. Available preventative vaccinations are also crucial. The incidence of HBV-associated vasculitides dramatically decreased following HBV vaccination campaigns, and other infection-associated vasculitides may as well in the future.

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“…Staphylococcus aureus (MRSA, MSSA) predominates, as well as CNS (MRSE, MSSE) and Pseudomonas aeruginosa (reviewed in [42]). Cases of linezolid resistant Streptococcus sanguinis [52] and Listeria monocytogenes [53] with associated leukocytoclastic vasculitis have also been reported.…”

Section: Infective Endocarditis and Pump/cannula Infectionsmentioning

confidence: 99%

Left Ventricular Assist Device Infections

Skalweit¹

2018

Advanced Concepts in Endocarditis

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Left ventricular assist device (LVAD) infections are important causes of morbidity and mortality in patients who receive these mechanical circulatory supports as a bridge to transplantation (BTT) or as destination therapy (DT) (for individuals who are not candidates for cardiac transplant). Infections are more common among persons who received pulsatile flow LVADs as opposed to newer continuous flow (CF) devices. Other risk factors for infection include obesity, renal failure, depression and immunosuppression. An LVAD infection increases the risk of infections in persons who undergo cardiac transplantation. Infections include percutaneous site, driveline, pump pocket and pump/cannula infections; sepsis, bacteremia, mediastinitis and endocarditis. Diagnosis is achieved by monitoring LVAD flow parameters and observing typical clinical and laboratory manifestations of infection. Imaging such as PET-CT or SPECT-CT imaging can be helpful to establish a diagnosis of pump pocket infection. Echocardiography may aid in detecting native valve endocarditis and thrombus associated with the LVAD. The most common pathogens include Staphylococcus, Corynebacterium, Enterococcus, Pseudomonas and Candida spp. Treatment requires targeted antimicrobials plus surgical debridement of infected tissue and device components. In cases of pump/cannula/LVAD endocarditis, especially if fungal pathogens or Mycobacterium chimaera are involved, LVAD removal/reimplantation vs. transplant is necessary, combined with extended antimicrobial therapy.

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A Case of Leukocytoclastic Vasculitis Caused byListeria monocytogenesBacteremia

Cited by 4 publications

References 16 publications

LVAD Vasculitis Case Series

LVAD Vasculitis Case Series

Infection‐associated vasculitides

Left Ventricular Assist Device Infections

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