A case of lip squamous cell carcinoma with a familial history of Xeroderma pigmentosum

Dartaha, Rami; Benmelouka, Amira Yasmine; Jobran, Afnan W.M.

doi:10.1016/j.oraloncology.2020.104896

Cited by 3 publications

(4 citation statements)

References 15 publications

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“…У больной установлены факторы риска развития актинического кератоза: II фототип кожи по Фитцпатрику, отягощенный профессиональный и солнечный анамнез (постоянная работа на открытом воздухе -работница сельскохозяйственного труда, фотопротекцию в течение жизни не использовала), признаки хронического фотоповреждения кожи (трофические изменения кожи, актинический эластоз) [2,3,[5][6][7][8][9][10][11][12][13][14].…”

Section: Discussionunclassified

“…К факторам риска возникновения актинического кератоза и актинического хейлита относят: избыточное кумулятивное ультрафиолетовое излучение; профессиональную деятельность и профессиональные вредности; отягощенный солнечный анамнез; I и II типы фоточувствительности кожи по Фитцпатрику; актинические поражения кожи и рубцы; генетические заболевания; рентгеновское и/или инфракрасное излучение; иммуносупрессию и иммунодефицитные состояния; низкий социально-экономический статус пациента; курение [1][2][3][5][6][7][8][9][10][11][12][13].…”

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“…В частности, у больных с пигментной ксеродермой риск малигнизации актинического кератоза повышен в 1000 раз, при этом регистрируют первично-множественный рак лица и губы. У пациентов с кожно-глазным альбинизмом ПКР открытых участков кожи встречается в 38,9% случаев [2,11,12].…”

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Actinic keratosis as a predictor of primary multiple synchronous squamous cell skin cancer: a clinical case

Седова

2023

Almanac of Clinical Medicine

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We present a clinical case of a primary multiple synchronous highly differentiated keratinizing squamous cell skin cancer in an 84-year old patient with multiple actinic keratosis and actinic cheilitis. The clinical case is unique for the simultaneous development of primary multiple squamous cell carcinoma of the tip of the nose and the vermilion zone of the lower lip in a patient with a past occupational and solar burden, a light phenotype, and signs of chronic photo injury the skin. Clinical, dermatoscopic and sonographic signs of keratotic actinic keratosis were identified in the patient and confirmed by pathomorphological examination. The risk factors for malignant transformation of actinic keratosis were found, such as multiple efflorescences and a long disease history. The malignant transformation of the actinic areas manifested as rapidly progressive ulceration zones more than 1 cm in diameter, pronounced hyperkeratosis, inflammation and infiltration of the underlying tissues, increased bleeding and pain. It is to be underlined that definitive and differential diagnosis requires pathomorphological assessment of the skin biopsy sample. This clinical case indicates that patients with multiple foci of actinic keratosis should be under a lifelong follow-up by dermatovenereologists, with mandatory treatment and prevention measure.

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Actinic keratosis as a predictor of primary multiple synchronous squamous cell skin cancer: a clinical case

Седова

2023

Almanac of Clinical Medicine

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“…47,48 The most prevalent skin cancers are squamous cell carcinoma followed by basal cell carcinoma and malignant melanoma. [49][50][51][52][53] Patients with XP have a 10,000-fold and 2000-fold increased risk over their lives of developing non-melanoma skin cancers (notably squamous cell carcinoma and basal cell carcinoma) and malignant melanoma, respectively. 34,54 The mean age for the first appearance of non-melanoma skin cancer and melanoma is 9 and 22 years, respectively, in patients with XP.…”

Section: Aetiopathogenesismentioning

confidence: 99%

Xeroderma pigmentosum: an updated review

Leung¹,

Barankin²,

Lam³

et al. 2022

DIC

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Background: Early recognition of xeroderma pigmentosum is important to minimize the complications arising from the harmful effects of exposure to ultraviolet radiation. This narrative review aims to familiarize physicians with the clinical features, diagnosis and management of xeroderma pigmentosum. Methods:A search was conducted in December 2021 in PubMed Clinical Queries using the key term "xeroderma pigmentosum". The search strategy included all clinical trials, observational studies and reviews published within the past 10 years. The information retrieved from the search was used in the compilation of this article.Results: Xeroderma pigmentosum is a condition of abnormal DNA repair of ultraviolet radiation-induced and oxidative DNA damage, which leads to increased skin cancer susceptibility. Approximately 50% of patients with xeroderma pigmentosum have increased photosensitivity and certain types of xeroderma pigmentosum are more prone to ocular disease and progressive neurodegeneration depending on the causative mutation. The diagnosis should be suspected in patients with increased photosensitivity and characteristic cutaneous, ophthalmological and neurological findings. A definite diagnosis can be made by the identification of biallelic mutation in one of the causative genes. Strict and consistent sun avoidance and protection and early detection and treatment of premalignant and malignant skin lesions are the mainstays of management. Treatment options for actinic keratosis include cryotherapy, topical imiquimod, topical 5-fluorouracil, chemical peeling, excision, CO 2 laser resurfacing, fractional/pulsed laser therapy, and photodynamic therapy. Cutaneous malignancy can be treated by photodynamic therapy, curettage and electrodesiccation, or surgical excision. Oral isotretinoin, oral niacinamide, topical imiquimod and topical fluorouracil can be used for the prevention of skin malignancy. Treatment options for poikiloderma include chemical peeling, dermabrasion and laser resurfacing. Methylcellulose eyedrops and soft ultraviolet-protective contact lenses may be used to keep the cornea moist and protect against the harmful effects of keratitis sicca. Investigational therapies include the use of T4 endonuclease-V liposome lotion and oral nicotinamide to reduce the rate of actinic keratoses and non-melanoma skin cancers and gene therapy for radical cure of this condition. Conclusion:Although currently there is no cure for xeroderma pigmentosum, increased awareness and early diagnosis of the condition, followed by rigorous sun avoidance and protection and optimal management, can dramatically improve the quality of life and life expectancy.

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Dermatoses of the Oral Cavity and Lips

Carey,

Setterfield

2024

Rook's Textbook of Dermatology

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A case of lip squamous cell carcinoma with a familial history of Xeroderma pigmentosum

Cited by 3 publications

References 15 publications

Actinic keratosis as a predictor of primary multiple synchronous squamous cell skin cancer: a clinical case

Actinic keratosis as a predictor of primary multiple synchronous squamous cell skin cancer: a clinical case

Xeroderma pigmentosum: an updated review

Dermatoses of the Oral Cavity and Lips

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