A Case of Liver Abscess with<i>Desulfovibrio desulfuricans</i>Bacteremia

Gut microbiome sequencing has shown promise as a predictive biomarker for a wide range of diseases, including classification of liver disease and severity grading. However, the potential of gut microbiota for prospective risk prediction of liver disease has not been assessed. Here, we utilise shallow gut metagenomic sequencing data of a large population-based cohort (N=>7,115) and ~15 years of electronic health register follow-up together with machine-learning to investigate the predictive capacity of gut microbial predictors, individually and in conjunction with conventional risk factors, for incident liver disease and alcoholic liver disease. Separately, conventional and microbiome risk factors showed comparable predictive capacity for incident liver disease. However, microbiome augmentation of conventional risk factor models using gradient boosted classifiers significantly improved performance, with average AUROCs of 0.834 for incident liver disease and 0.956 for alcoholic liver disease (AUPRCs of 0.185 and 0.304, respectively). Disease-free survival analysis showed significantly improved stratification using microbiome-augmented risk models as compared to conventional risk factors alone. Investigation of predictive microbial signatures revealed a wide range of bacterial taxa, including those previously associated with hepatic function and disease. This study supports the potential clinical validity of gut metagenomic sequencing to complement conventional risk factors for risk prediction of liver diseases.

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“…[43, 44] , Desulfovibrio spp . [45] , etc. have been identified as pathogens for liver abscess and sepsis.…”

Section: Resultsmentioning

confidence: 99%

Early prediction of liver disease using conventional risk factors and gut microbiome-augmented gradient boosting

Liu

Méric

Havulinna

et al. 2020

Preprint

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“…Desulfovibrio fairfieldensis has been isolated from the blood of a patient suffering from perforating appendicitis (Loubinoux, Mory, Pereira, & Le Faou, 2000), while D. desulfuricans together with Eggerthella lenta was indicated as the cause of a polymicrobial bloodstream infection (Liderot, Larsson, Boräng, & Ozenci, 2010). A monobacterial bacteraemia resulting from a liver abscess was found to be due to D. desulfuricans (Koyano et al, 2015).…”

Section: Infections and Bacteraemiamentioning

confidence: 99%

A Post-Genomic View of the Ecophysiology, Catabolism and Biotechnological Relevance of Sulphate-Reducing Prokaryotes

Rabus

Venceslau

Wöhlbrand

et al. 2015

Advances in Microbial Physiology

265

286

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“…Figure 3 summarizes the association of SRB with diseases. In addition, several case studies have reported D. desulfuricans bacteremia under different clinical conditions [ 69 , 70 , 71 ]. Some studies have highlighted the effects of probiotic and prebiotic treatments on SRB population in the gut.…”

Section: Impact Of Srb Bacterial Derived H 2 Smentioning

confidence: 99%

Hydrogen Sulfide in Physiology and Diseases of the Digestive Tract

2015

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Hydrogen sulfide (H2S) is a Janus-faced molecule. On one hand, several toxic functions have been attributed to H2S and exposure to high levels of this gas is extremely hazardous to health. On the other hand, H2S delivery based clinical therapies are being developed to combat inflammation, visceral pain, oxidative stress related tissue injury, thrombosis and cancer. Since its discovery, H2S has been found to have pleiotropic effects on physiology and health. H2S is a gasotransmitter that exerts its effect on different systems, such as gastrointestinal, neuronal, cardiovascular, respiratory, renal, and hepatic systems. In the gastrointestinal tract, in addition to H2S production by mammalian cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE), H2S is also generated by the metabolic activity of resident gut microbes, mainly by colonic Sulfate-Reducing Bacteria (SRB) via a dissimilatory sulfate reduction (DSR) pathway. In the gut, H2S regulates functions such as inflammation, ischemia/ reperfusion injury and motility. H2S derived from gut microbes has been found to be associated with gastrointestinal disorders such as ulcerative colitis, Crohn’s disease and irritable bowel syndrome. This underscores the importance of gut microbes and their production of H2S on host physiology and pathophysiology.

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A Case of Liver Abscess withDesulfovibrio desulfuricansBacteremia

Cited by 11 publications

References 17 publications

Early prediction of liver disease using conventional risk factors and gut microbiome-augmented gradient boosting

Early prediction of liver disease using conventional risk factors and gut microbiome-augmented gradient boosting

A Post-Genomic View of the Ecophysiology, Catabolism and Biotechnological Relevance of Sulphate-Reducing Prokaryotes

Hydrogen Sulfide in Physiology and Diseases of the Digestive Tract

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