A Case of Localized Cutaneous Infection Caused by Scedosporium apiospermum Presenting as Cellulitis

Noh, Soo Hyeon; Na, Ga Hye; Park, Kun; Kim, Eun Jung

doi:10.5021/ad.2017.29.5.640

Cited by 5 publications

(1 citation statement)

References 5 publications

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“…[9][10][11] Furthermore, the increased incidence of S. apiospermum infections was reported to be because of the extensive use of corticosteroids, immunosuppressants, antineoplastics, broad-spectrum antibiotics, and indwelling catheters including long-term CVC. 1,[12][13][14][15][16] In some cases, S. apiospermum infections following medical intervention were isolated from the insertion site of a catheter, indicating a significant evidence of nosocomial diseases. 13 The recent study has exhibited that S. apiospermum can form biofilms on the surface of both polystyrene and polyurethane, a material of CVC.…”

Section: Introductionmentioning

confidence: 99%

Tryptophol Coating Reduces Catheter-Related Cerebral and Pulmonary Infections by Scedosporium apiospermum

Kitisin¹,

Muangkaew²,

Ampawong³

et al. 2020

IDR

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Introduction: Central venous catheter (CVC) is a medical device that is used to administer medication for a long duration. Colonization by an emerging opportunistic pathogen Scedosporium apiospermum in the CVC lumen is frequently reported to cause severe complications in patients. Here, we describe the effect of fungal quorum-sensing molecule (QSM) known as tryptophol (TOH) to control S. apiospermum colonization in catheter tube lumens in both in vitro and in vivo models. Methods: Antifungal susceptibility of TOH against S. apiospermum was compared with voriconazole, and the colony diameter was determined on days 2, 4, and 6. Experimental catheterization rat model was conducted with pre-coating of TOH and voriconazole or an uncoated control and an infection with S. apiospermum. Biofilm formation on the catheter luminal surface was assessed using the scanning electron microscopy, crystal violet, and 2,3-bis(2-methoxy-4-ni-tro-5-sulfophenyl)-5-(phenylamino)-carbonyl-2H-tetra-zolium hydroxide (XTT) reduction assays. Brain and lung samples of catheterized rats were histopathologically assessed. Serum samples from catheterized rats were injected into Galleria mellonella larvae. Survival of catheterized rats and G. mellonella was determined. Results: TOH impeded the growth of S. apiospermum by reducing the colony diameter in a dose-dependent manner. TOH coating remarkably lessened S. apiospermum biofilm formation and fungal cell viability on the catheter luminal surface. Additionally, TOH coating lessens cerebral edema that is associated with abscess and invasive pulmonary damages due to S. apiospermum catheter-related infection. Furthermore, TOH coating also lessened the virulence of S. apiospermum in sera of experimental catheterized rats and extended the survival rate of larvae Galleria mellonella infection model. Conclusion: An alternative modification of catheter by coating with TOH is effective in preventing S. apiospermum colonization in vivo. Our study gives a new strategy to control catheter contamination and prevents nosocomial diseases due to S. apiospermum infection.

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Section: Introductionmentioning

confidence: 99%

Tryptophol Coating Reduces Catheter-Related Cerebral and Pulmonary Infections by Scedosporium apiospermum

Kitisin¹,

Muangkaew²,

Ampawong³

et al. 2020

IDR

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Scedosporium apiospermum infection mimicking erythema nodosum: the importance of culture samples in immunocompromised patients with panniculitis

et al. 2022

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Superficial mycoses, a matter of concern: Global and Indian scenario‐an updated analysis

Sharma

Nonzom

2021

Mycoses

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Superficial mycoses are the fungal infections restricted to the outermost non-living layers of the skin and its appendages viz., hair and nails. Their prevalence rate has been reported to be 20%-25% 1 and vary with respect to occupational groups, gender, age group, etc. These infections are more common in tropical as well as subtropical countries where heat, humidity and other favourable conditions aid in their acquisition and maintenance. Although superficial mycotic infections are usually limited to the skin and mucous membranes, these infections are hardly life-threatening but they have importance because of their worldwide distribution, morbidity and transmission from one person/animal to another.Over the last decades, it has been observed that an increasing number of non-dermatophytic fungi, like, Alternaria, Aspergillus, Chaetomium, Curvularia, Fusarium, Penicillium, Scopulariopsis and Trichosporon, have also emerged as causal agents of superficial mycoses in humans, producing almost clinically similar lesions as caused by dermatophytes. 2,3 Although both dermatophytes and non-dermatophytes have been known to cause superficial mycoses all over the world, their incidence, distribution, prevalence, epidemiology, clinical manifestation and target hosts may vary from region to region. 4,5 In this review, more emphasis has been provided on information related to skin and hair infections.

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A Case of Localized Cutaneous Infection Caused by Scedosporium apiospermum Presenting as Cellulitis

Cited by 5 publications

References 5 publications

<p>Tryptophol Coating Reduces Catheter-Related Cerebral and Pulmonary Infections by <em>Scedosporium apiospermum</em></p>

<p>Tryptophol Coating Reduces Catheter-Related Cerebral and Pulmonary Infections by <em>Scedosporium apiospermum</em></p>

Scedosporium apiospermum infection mimicking erythema nodosum: the importance of culture samples in immunocompromised patients with panniculitis

Superficial mycoses, a matter of concern: Global and Indian scenario‐an updated analysis

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