A Case of Lung Cancer Originating from Cavitary<i>Mycobacterium xenopi</i>Infection

Doshi, Viral; Kulkarni, Shreedhar; Kham, Nang; Kapitan, K. S.

doi:10.4187/respcare.03549

Cited by 5 publications

(2 citation statements)

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“…Although, bacterial infections are not considered as major threats to cancer, yet a number of bacterial pathogens are reported to be associated with several cancers. Some examples include: Mycoplasma in prostate malignancy [ 4 ], Robinsoniella in pancreatic cancer [ 5 ], S. typhi, H. bilis, H. hepaticus, and E. coli in carcinoma of the gallbladder [ 6 ], Chlamydia in cervical cancer [ 7 ] and Mycobacterium in lung cancer [ 8 , 9 , 10 , 11 , 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Linking common non-coding RNAs of human lung cancer and M. tuberculosis

et al. 2018

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Lung cancer and pulmonary tuberculosis caused by Mycobacterium are two major causes of deaths worldwide. Tuberculosis linked lung cancer is known. However, the precise molecular mechanism of Mycobacterium associated increased risk of lung cancer is not understood. We report 45 common human miRNAs deregulated in both pulmonary tuberculosis and lung cancer. We show that sRNA_1096 and sRNA_1414 from M. tuberculosis have sequence homology with human mir-21. Hence, the potential role of these three small non-coding RNAs in rifampicin resistance in pulmonary tuberculosis is implied. Further, the linking of sRNA_1096 and sRNA_1414 from M. tuberculosis with the host lung tumorigenesis is inferred. Nonetheless, further analysis and validation is required to associate these three non-coding RNAs with Mycobacterium associated increased risk of lung cancer.

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Section: Introductionmentioning

confidence: 99%

Linking common non-coding RNAs of human lung cancer and M. tuberculosis

et al. 2018

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“…Although, bacterial infections are not considered as major threats to cancer, yet a number of bacterial pathogens are reported to be associated with several cancers. Some examples include: Mycoplasma in prostate malignancy [4], Robinsoniella in pancreatic cancer [5], S. typhi, H. bilis, H. hepaticus, and E. coli in carcinoma of the gallbladder [6], Chlamydia in cervical cancer [7], and Mycobacterium in lung cancer [8][9][10][11][12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

A potential link between tuberculosis and lung cancer through non-coding RNAs

Barh¹,

Tiwari²,

et al. 2017

Preprint

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; Tel/Fax: +91 944 955 0032 not peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission.The copyright holder for this preprint (which was . http://dx.doi.org/10.1101/188375 doi: bioRxiv preprint first posted online Sep. 13, 2017; 2 | P a g e ABSTRACT Pulmonary tuberculosis caused by Mycobacterium and lung cancer are two major causes of deaths worldwide and the former increases the risk of developing lung cancer. However, the precise molecular mechanism of Mycobacterium associated increased risk of lung cancer is not entirely understood. Here, using in silico approaches, we show that hsa-mir-21 and M. tuberculosis sRNA_1096 and sRNA_1414 could play important roles in the pathogenesis of both these diseases. Further, we postulated a "Genetic remittance" hypothesis where these sRNAs may play important roles. The sRNA_1096 could be involved in tuberculosis through multiple infectious processes, and if transferred to the host, it may activate the TLR8 mediated pro-metastatic inflammatory pathway by acting as a ligand to TLR8 similar to the mir-21 leading to lung tumorigenesis and chemo-resistance. Analogous to SH3GL1, it may also regulate cell cycle. On the other hand, sRNA_1414 is probably involved in survivability and drug response of the pathogen. However, it may be a metastatic factor for lung cancer providing EPS8L1 and SORBS1 like functions upon remittance. Further, all these three noncoding RNAs are predicted to act in rifampicin resistance in Mycobacterium. Currently, we are applying robust bioinformatics strategies and conducting experimental validations to confirm our in-silico findings and hypothesis.

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