A case of lupus mastitis in a patient with systemic lupus erythematosus

Tanaka, Yumiko; Manabe, Hironobu; Shinzaki, Wataru; Hashimoto, Yukihiko; Komoike, Y.

doi:10.1111/tbj.13582

Cited by 7 publications

(13 citation statements)

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“…SLE is rarely associated with mastitis as part of lupus panniculitis, which often involves the breasts; however, this typical lupus mastitis is rare, and only a few cases have been reported in the literature [ 14 - 20 ]. In addition to the well-characterized cases of lupus, ANAs were detected in 50 out of 78 patients with non-lactational mastitis in one study [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Granulomatous Mastitis Associated With Positive Systemic Lupus Erythematosus Serology in a Young Female Patient: A Case Report and Literature Review

Abdalla¹,

Saad²,

Abdulrahman³

et al. 2023

Cureus

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Granulomatous mastitis (GM) is a rare benign breast disease that affects women of childbearing age, usually within five years of pregnancy. The hallmark diagnostic feature of GM is the presence of lobular granulomatous inflammation. The occurrence of this clinicopathological entity is usually idiopathic. Nevertheless, GM has often been associated with systemic inflammatory conditions of either infectious (such as tuberculosis) or autoimmune etiology (particularly sarcoidosis, vasculitis, and less likely systemic lupus erythematosus [SLE]). In this report, the authors described an unusual case of GM that was associated with features of SLE in a young female patient who presented with a painful breast lump. Histopathological examination of the lump’s biopsy showed GM. Further laboratory workup revealed evidence of some immunological criteria of SLE. Steroid therapy led to the resolution of the patient’s breast swelling. The breast mass remained in remission with hydroxychloroquine treatment. Only a handful of similar cases in the current literature demonstrated a plausible association between SLE and GM. Our case provides a reference to consider SLE as a possible differential diagnosis when GM is encountered in young-aged female patients.

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Section: Discussionmentioning

confidence: 99%

A Rare Case of Granulomatous Mastitis Associated With Positive Systemic Lupus Erythematosus Serology in a Young Female Patient: A Case Report and Literature Review

Abdalla¹,

Saad²,

Abdulrahman³

et al. 2023

Cureus

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“…In addition, the reported MRI findings showed skin thickening, fat stranding, and hyperintense signals on T2-weighted MRI sequences. 2,3,8 Because of this, often the clinical differential diagnoses include infection, inflammatory carcinoma, granulomatous mastitis, diabetic mastopathy, and in rare cases with bilateral breast enlargement and tenderness, non-Hodgkin lymphoma. 3 Thus, this entity is a source of great diagnostic dilemma for both clinicians and radiologists.…”

Section: Discussionmentioning

confidence: 99%

Rare Initial Manifestation of Lupus as Lobular Panniculitis of the Breast—A Case Report and Review of the Literature

Sharma

Blank²,

Komforti³

2020

The American Journal of Dermatopathology

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Lupus mastitis is a rare complication of systemic or discoid lupus erythematosus with an uncommon initial presentation when limited to the breast. In this article, we report a 42-year-old woman who presented with constant pain and tenderness in her breasts. Ultrasound imaging of the left breast revealed a 14-mm oval mass, suspicious for malignancy; a needle core biopsy was performed. Sections showed necrosis of the fat lobules with associated mixed nodular lymphoplasmacytic aggregates. Karyorrhectic debris, fibrinoid necrosis of small vessels, and microcalcifications were all present while the background breast parenchyma was unremarkable. The diagnosis of lupus mastitis was rendered. Subsequent serology showed negative dsDNA but positive antinuclear antibodies, C4, and anti -Sjögren';ssyndrome-related antigen A antibodies. Clinical features of active systemic disease were not identified at the patient's follow-up dermatology appointment 1 month after the biopsy, and she elected management for her nodules with steroids. To the best of our knowledge, only 40 other cases of lupus mastitis have been reported in the English literature, of which 25 presented as a mass and only in 6 lupus mastitis of the breast was the initial presentation. In conclusion, we bring much needed awareness to lupus mastitis as the first presentation of disease.

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“…So far, 27 cases have been reported in the literature: Kinonen and coll. reviewed 22 cases and 6 additional cases have since been reported [38][39][40][41][42][43][44].…”

Section: Lupusmentioning

confidence: 99%

Mastitis in Autoimmune Diseases: Review of the Literature, Diagnostic Pathway, and Pathophysiological Key Players

Goulabchand

Hafidi

Perre

et al. 2020

JCM

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Mastitis frequently affects women of childbearing age. Of all the pathological breast conditions requiring specific management, autoimmune mastitis is in the third position after infection and breast cancer. The aim of this literature review was to make a comprehensive description of autoimmune diseases targeting the mammary gland. Four main histological patterns of autoimmune mastitis are described: (i) lymphocytic infiltrates; (ii) ductal ectasia; (iii) granulomatous mastitis; and (iv) vasculitis. Our literature search found that all types of autoimmune disease may target the mammary gland: organ-specific diseases (diabetes, thyroiditis); connective tissue diseases (such as systemic erythematosus lupus or Sjögren’s syndrome); vasculitides (granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, giant cell arteritis, polyarteritis nodosa, Behçet’s disease); granulomatous diseases (sarcoidosis, Crohn’s disease); and IgG4-related disease. Cases of breast-specific autoimmune diseases have also been reported, including idiopathic granulomatous mastitis. These breast-limited inflammatory diseases are sometimes the first symptom of a systemic autoimmune disease. Although autoimmune mastitis is rare, it is probably underdiagnosed or misdiagnosed. Early diagnosis may allow us to detect systemic diseases at an earlier stage, which could help to initiate a prompt, appropriate therapeutic strategy. In case of suspected autoimmune mastitis, we hereby propose a diagnostic pathway and discuss the potential pathophysiological pathways leading to autoimmune breast damage.

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A case of lupus mastitis in a patient with systemic lupus erythematosus

Cited by 7 publications

References 0 publications

A Rare Case of Granulomatous Mastitis Associated With Positive Systemic Lupus Erythematosus Serology in a Young Female Patient: A Case Report and Literature Review

A Rare Case of Granulomatous Mastitis Associated With Positive Systemic Lupus Erythematosus Serology in a Young Female Patient: A Case Report and Literature Review

Rare Initial Manifestation of Lupus as Lobular Panniculitis of the Breast—A Case Report and Review of the Literature

Mastitis in Autoimmune Diseases: Review of the Literature, Diagnostic Pathway, and Pathophysiological Key Players

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