A case of lymphoepithelioma-like carcinoma of the uterine cervix in a patient with a history of high-grade squamous intraepithelial lesion

Étude immunohistochimique des Papilloma virus et Epstein-Barr virus chez les patientes avec carcinome de type lympho-épithélioma du col utérin Introduction. Le carcinome de type lympho-épithélioma (LELC) du col utérin est un type rare de carcinome à cellules squameuses (SSC). Il diffère du SSC habituel du col de l'utérus par sa morphologie et son comportement clinique et présente un meilleur pronostic que le SSC plus commun du col de l'utérus. On considère que la LELC est associée à l'infection par le virus Epstein-Barr (EBV) chez les asiatiques et au virus du papillome humain (VPH) ou à l'absence d'infection chez les patients de race blanche. L'objectif de l'étude est de confirmer si la LELC est plus fréquente chez les patients de race blanche

show abstract

“…In two cases we found both viruses. This is similar to the results published in the literature [28][29][30] .…”

Section: Discussionsupporting

confidence: 92%

Immunohistochemical study of Human Papilloma Virus and Epstein–Barr virus in patients with lymphoepithelioma-like carcinoma of the uterine cervix

Yordanov¹,

Karcheva²,

Betova³

et al. 2019

Arch Balk Med Union

View full text Add to dashboard Cite

show abstract

“…In the presented case, FIGO staging was defined as IB1 according to the pre-2019 classification. In most cases in the available studies (12)(13)(14)16) , the postoperative pathological classification in force before 2019 had the same degree of advancement. According to Yordanov et al, this degree of advancement concerns 82.4% (5) .…”

Section: Discussionmentioning

confidence: 94%

“…Cervical squamous cell carcinoma of the cervix with profuse lymphoid stroma is a rare neoplasm. The available literature has described few similar cases (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17) . The presented case of LELC represents the first Polish report and one of the few reports in the world.…”

Section: Discussionmentioning

confidence: 99%

“…Umiejscowienie raka płaskonabłonkowego z obfitym podścieliskiem limfoidalnym w szyjce macicy jest rzadkie. W piśmiennictwie z ostatnich 20 lat znaleziono jedynie 16 doniesień, w tym 11 dotyczących jednego przypadku (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17) , a 5 doniesień zawierały krótkie serie kilku przypadków (2,3,5,18,19) . W piśmiennictwie polskim nie znaleziono opisu przypadku raka płaskonabłonkowego szyjki macicy z obecnością obfitego podścieliska limfoidalnego.…”

Section: Fig 1 Ct Of the Small Pelvis (Sagittal Scan) Vur -Bladder Cu...unclassified

“…According to Yordanov et al (2) , the localization of LELC in the cervix was first described in 1968 by Hamazaki et al A localization of lymphoepithelioma-like carcinoma in the uterine cervix is rare. The literature from the last 20 years contains merely 16 reports, including 11 concerning 1 case (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17) , and 5 reports contain brief series of several cases (2,3,5,18,19) . The Polish literature mentions no case reports of lymphoepithelioma-like carcinoma of the uterine cervix.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Stage FIGO IB1 lymphoepithelioma-like carcinoma of the uterine cervix in a 57-year-old female

Trawińska¹,

Bielatowicz²,

Gawlik³

et al. 2022

Curr Gynecol Oncol

View full text Add to dashboard Cite

Lymphoepithelioma-like carcinoma (LELC) of the uterine cervix is a rare type of cervical cancer. The etiopathogenesis of cervical LELC involves consideration of the human papillomavirus (HPV) and Epstein–Barr virus infection. We present the case of a 57-year-old female diagnosed with a unique HPV-59 with the absence of Epstein–Barr virus, which is characteristic for European women. The treatment included a radical hysterectomy with nerve-sparing radical hysterectomy, which has not been used in patients with LELC so far. Complementary treatment included combined radiotherapy and cisplatin infusion.

show abstract

Inflammatory Stroma of Lymphoepithelioma-like Carcinoma of the Cervix: Immunohistochemical Study of 3 Cases and Review of the Literature

Philippe

Rassy²,

Craciun³

et al. 2018

International Journal of Gynecological Pathology

View full text Add to dashboard Cite

The aim of this study was to characterize the inflammatory infiltrate of the lymphoepithelioma-like carcinoma, a variant of squamous cell carcinoma clinically associated with a good prognosis. Immunohistochemistry was used to characterize 3 cases of lymphoepithelioma-like carcinoma in the uterine cervix, diagnosed over a period of 3 yr. The patients were between 30 and 50 yr old. Their cervical smears had shown atypical squamous cells of unknown significance or high-grade squamous intraepithelial lesions, and the initial cervical biopsy showed high-grade cervical intraepithelial neoplasia (CIN3) or squamous cell carcinoma. All patients underwent a Wertheim operation, 2 of which were preceded by a cervicectomy. Microscopically, all tumors were characterized by poorly defined sheets of undifferentiated squamous cells with a syncytial pattern and a dense background of infiltrating lymphocytes. Immunohistochemical analysis revealed that the lymphocytes were predominantly CD3 and CD8 T cells. The tumor lobules contained isolated CD8 T cells, whereas CD4 T cells and CD20 B cells surrounded the tumor lobules. CD56 NK cells and CD79 B cells were scattered in the tumor tissue. An in situ hybridization staining for Epstein-Barr encoding region was negative but all cases were immunohistochemically positive for P16. Follow-up varied between 2 mo and 2.7 yr. All 3 patients were disease free. Lymphoepithelioma-like carcinoma of the uterine cervix is a variant of squamous cell carcinoma, known for its better prognosis. The good prognosis of this tumor is potentially explained by the high levels of infiltrating CD8 T cells.

show abstract

A case of lymphoepithelioma-like carcinoma of the uterine cervix in a patient with a history of high-grade squamous intraepithelial lesion

Cited by 4 publications

References 4 publications

Immunohistochemical study of Human Papilloma Virus and Epstein–Barr virus in patients with lymphoepithelioma-like carcinoma of the uterine cervix

Immunohistochemical study of Human Papilloma Virus and Epstein–Barr virus in patients with lymphoepithelioma-like carcinoma of the uterine cervix

Stage FIGO IB1 lymphoepithelioma-like carcinoma of the uterine cervix in a 57-year-old female

Inflammatory Stroma of Lymphoepithelioma-like Carcinoma of the Cervix: Immunohistochemical Study of 3 Cases and Review of the Literature

Contact Info

Product

Resources

About