A case of lymphomatoid papulosis and Hodgkin's disease

Pinto, Gabriela Marques; Gonçalves, Luis; Gonçalves, Hélder Santos; Graça, Felicidade; Quental, Ana; Fonseca, Isabel Pereira da; Monteiro, Amélia

doi:10.1016/s0190-9622(89)70294-2

Cited by 17 publications

(9 citation statements)

References 44 publications

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“…LyP is preceded by, associated with, or followed by malignant lymphoma in a proportion of patients 7 . In most of these cases, LyP is noted to have existed prior to the lymphoma 8,9 . In the present case, LyP was observed 18 months after the intensive chemotherapy for aggressive cutaneous ALCL.…”

Section: Discussionmentioning

confidence: 47%

CD30+ lymphoproliferative disorder: primary cutaneous anaplastic large cell lymphoma followed by lymphomatoid papulosis.

Aoki¹,

Niimi²,

Takezaki³

et al. 2001

Br J Dermatol

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CD30+ large anaplastic lymphoid cells are seen in anaplastic large cell lymphoma (ALCL), and also in lymphomatoid papulosis (LyP) and other lymphoproliferative disorders. It can be difficult precisely to categorize these disorders with CD30+ cells. We report a case of primary cutaneous CD30+ ALCL with systemic metastases in whom the clinical disease subsequently evolved into LyP. The patient was initially administered cisplatin and etoposide and made a good response. Eighteen months later, recurrent, self-healing cutaneous small nodules appeared around the original tumour site without any systemic involvement. Histopathological examination of the recurrent lesions revealed infiltration with a mixture of cells that included neutrophils, eosinophils and CD30+ large anaplastic cells cytologically identical with those in the primary lesion. The anaplastic cells in both the primary and recurrent lesions were positive for monoclonal antibodies CD30, CD25 and a monoclonal antibody directed against the chimeric protein p80(NPM-ALK). These observations suggest the possibility that the ALCL and the subsequent LyP represent different clinical manifestations of proliferation of the same clone.

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Section: Discussionmentioning

confidence: 47%

CD30+ lymphoproliferative disorder: primary cutaneous anaplastic large cell lymphoma followed by lymphomatoid papulosis.

Aoki¹,

Niimi²,

Takezaki³

et al. 2001

Br J Dermatol

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“…7 LyP can be seen in association with other lymphoproliferative disorders. [8][9][10][11][12][13][14][15][16][17][18] The lymphoma most commonly associated with LyP is MF. The coexistence of MF and LyP in a patient is readily appreciated with the distinct morphologies yet gene studies reveal the same clonal rearrangement of the T-cell receptor gene.…”

mentioning

confidence: 99%

Persistent agmination of lymphomatoid papulosis: An equivalent of limited plaque mycosis fungoides type of cutaneous T-cell lymphoma

Heald

Subtil

Breneman

et al. 2007

Journal of the American Academy of Dermatology

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“…Therapy does not appear to alter the natural history of LyP or the risk of developing associated malignancy (Pinto et al . 1989;Beljaards & Willemze 1992).…”

Section: Discussionmentioning

confidence: 99%

Consequences of misdiagnosis of lymphomatoid papulosis

2006

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We report two patients with lymphomatoid papulosis (LyP), who were initially diagnosed as systemic T-cell lymphoma. The patients presented with recurrent self-healing cutaneous lesions and skin biopsies showed a lymphocytic infiltrate with malignant features. Clinico-pathological correlation of findings was not performed and results of staging investigations were misinterpreted. Consequently, both patients were unnecessarily treated with multi-agent chemotherapy, radiotherapy and stem cell/bone marrow transplants and sustained long-term adverse effects. The clinical and histological features of LyP are described and appropriate management discussed in detail. Factors leading to the unnecessary treatment of both patients are examined and several learning points highlighted such as the importance of a multidisciplinary approach.

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A case of lymphomatoid papulosis and Hodgkin's disease

Cited by 17 publications

References 44 publications

CD30+ lymphoproliferative disorder: primary cutaneous anaplastic large cell lymphoma followed by lymphomatoid papulosis.

CD30+ lymphoproliferative disorder: primary cutaneous anaplastic large cell lymphoma followed by lymphomatoid papulosis.

Persistent agmination of lymphomatoid papulosis: An equivalent of limited plaque mycosis fungoides type of cutaneous T-cell lymphoma

Consequences of misdiagnosis of lymphomatoid papulosis

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