A Case of Malignant Lymphoma in the Residual Stomach.

Tsuji, Fukumasa; Kimura, F; Yamasaki, Yoshisada; Yamanaka, Youichi; Yamamoto, Masahiko

doi:10.5833/jjgs.25.2968

Cited by 3 publications

(1 citation statement)

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“…Regarding the etiology of malignant lymphoma after a gastrectomy, the reflux of duodenal contents, decreased acid levels, and bacterial translocation could lead to the development of chronic atrophic gastritis, which may induce a continuous proliferation of lymphoid tissue and malignant changes. 9 The association of H. pylori with mucosa-associated lymphoid tissue lymphoma has been substantiated in recent studies. The frequency of H. pylori has been reported to range from 56% to 100% in patients with gastric lymphoma.…”

Section: Discussionmentioning

confidence: 95%

A Collision Tumor Composed of Adenocarcinoma and Malignant Lymphoma in the Remnant Stomach After Pancreatoduodenectomy: Report of a Case

Manabe¹,

Nishihara²,

Kurokawa³

et al. 2001

Surgery Today

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The occurrence of a collision tumor in the stomach, consisting of adenocarcinoma and malignant lymphoma, is extremely rare. We report herein the case of a patient who had undergone a pancreatoduodenectomy for bile duct cancer 5 year earlier, in whom an ulcerating tumor of the remnant stomach developed and grew rapidly within 5 months. Surgical exploration revealed a tumor in the remnant stomach, multiple liver metastases, and multiple lymph node metastases. Total resection of the remnant stomach was performed, and pathological examination revealed a collision tumor consisting of adenocarcinoma and malignant lymphoma. The patient died of liver metastases and lymph node metastases 7 months after his second operation. The coexistence of both adenocarcinoma and malignant lymphoma of the remnant stomach and the etiology of this unusual combination, never previously reported, is discussed.

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Section: Discussionmentioning

confidence: 95%

A Collision Tumor Composed of Adenocarcinoma and Malignant Lymphoma in the Remnant Stomach After Pancreatoduodenectomy: Report of a Case

Manabe¹,

Nishihara²,

Kurokawa³

et al. 2001

Surgery Today

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Non-Hodgkin's lymphoma of the gastric stump developing 9 years after a distal gastrectomy for a peptic ulcer: A case report and review of the literature

et al. 1994

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We report herein the case of a 65-year-old man who developed non-Hodgkin's lymphoma of the gastric stump 9 years after undergoing a distal gastrectomy for a gastric ulcer. The patient presented with epigastric discomfort, and an upper gastrointestinal series and gastroscopy revealed a lymphoma lesion located close to the site of his gastroduodenal anastomosis. A total gastrectomy was performed, followed by combination chemotherapy, comprised of vincristine, Endoxan, prednisone and Adriamycin (VEPA). Histologically, the resected specimen was diagnosed as non-Hodgkin's lymphoma. The patient has remained well without any signs of recurrence for 18 months since his operation. Although there have been a number of reports of adenocarcinoma developing in the gastric stump following surgery for peptic ulcers, the development of malignant lymphoma under such conditions is rare. Following the presentation of this case, we review the available literature and discuss the possibility of malignant lymphoma developing in the gastric stump.

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Malignant lymphoma occurring in the residual stomach following gastrectomy: plus discussion based on the literature in Japan

et al. 2003

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A 53-year-old man was examined because of mild anemia (hemoglobin [Hb], 11.6g/dl) in August 1996. He had undergone pyloric gastrectomy with Billroth-I reconstruction for perforated benign gastric ulcer in 1988. Gastric transillumination and endoscopy showed comparatively soft, giant fold-like protruding lesions spreading over the entire residual stomach, and biopsy revealed the lesions to be malignant lymphoma. X-Rays of the large intestine and colonoscopy with biopsy demonstrated Borrmann type 2 highly differentiated adenocarcinoma in the upper rectum. At laparotomy in November 1996, a tumor was observed throughout the residual stomach. Lymph nodes were enlarged around the stomach and along the common hepatic artery and splenic artery and in the hepatoduodenal ligament. Total gastrectomy with splenectomy and purging of the lymph nodes was performed, in addition to a lower anterior resection of the rectum for the rectal cancer. The surgical specimen, which consisted of a 12 ϫ 9-cm gastric stump, showed giant fold-like protruding lesions occupying the entire residual stomach (Fig. 1). Histological examinations revealed large lymphocyte-like cells with a round or cleaved nucleus infiltrating across the proper muscle layer from the mucous membrane of the stomach wall. Similar cellular infiltration was also observed for lymph nodes nos. 1, 2, 3, 4sb, 8a, 10, 11, 12, and 272 (lymph nodes along the iliac artery). According to the results of immunohistological studies, the tumor was positive for B-cell markers, i.e., CD20 and CD45RA, and negative for T-cell markers, i.e., CD3 and CD45RO. In addition, both heavy-chain immunoglobulin IgM and light-chain k were strongly and monoclonally positive. These features were diagnostic of B-cell lymphoma of the diffuse, large-cell type. Helicobacter pylori microorganisms were demonstrated at the luminal surface of the tumor. The histology of the rectal cancer was highly differentiated adenocarcinoma

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A Case of Malignant Lymphoma in the Residual Stomach.

Cited by 3 publications

References 0 publications

A Collision Tumor Composed of Adenocarcinoma and Malignant Lymphoma in the Remnant Stomach After Pancreatoduodenectomy: Report of a Case

A Collision Tumor Composed of Adenocarcinoma and Malignant Lymphoma in the Remnant Stomach After Pancreatoduodenectomy: Report of a Case

Non-Hodgkin's lymphoma of the gastric stump developing 9 years after a distal gastrectomy for a peptic ulcer: A case report and review of the literature

Malignant lymphoma occurring in the residual stomach following gastrectomy: plus discussion based on the literature in Japan

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