A Case of Megaloblastic Anemia with Thrombocytopenia

Abstract

Megaloblastic anemias are a group of hematologic disorders in which abnormal DNA synthesis causes blood and bone marrow disorders. This type of anemias occurs as a result of folic acid deficiency or impaired vitamin B12 absorption. The prevalence of this type of anemia is highly variable worldwide and megaloblastic anemia caused by lack of vitamin B12 (cyanocobalamin) is rare during pregnancy [1]. In this case report, we report follow-ups conducted for a pregnant 33-yearold woman, G2, P1, with a history of previous natural childbirth who attended Kamali Hospital due to labor pain associated with severe thrombocytopenia. Although this woman was injected 10 units of PLT and also vitamin B12 (cyanocobalamin), folic acid and corticosteroids in the course of treatment, her platelet level has not yet returned to normal levels after 6 months and she is still being treated.

Thrombocytopenia and associated factors among pregnant women attending antenatal care at Hiwot Fana Comprehensive Specialized Hospital, Eastern Ethiopia: A cross-sectional study

“…[17] Other causes include infection such as malaria, and hematological diseases such as leukemia, megaloblastic anemia, aplastic anemias, type II von Willebrand disease, and disseminated intravascular coagulation. [18][19][20] TCP typically results in mucosal bleeding consequent to primary hemostasis defect, and it can be noticed with different clinical presentations including epistaxis, gingival bleeding, abnormal uterine bleeding, petechiae, and ecchymosis. [13,15] The obvious concern with TCP during pregnancy is the risk of significant bleeding at the time of delivery or after childbirth, and it needs regular follow-up.…”

“…[17] Other causes include infection such as malaria, and hematological diseases such as leukemia, megaloblastic anemia, aplastic anemias, type II von Willebrand disease, and disseminated intravascular coagulation. [18–20]…”