A Case of Mesenchymal Chondrosarcoma of the Orbit

Abstract

A case of mesenchymal chondrosarcoma occurring in the right orbit of a 84-year-old Japanese female was reported. The ultrastructural findings of tumour are composed of three cell types: well-differentiated cartilaginous cells, undifferentiated cells and transitional cells. The well-differentiated cells showed scalloped cytoplasmic membranes, numerous mitochondria showing dense electron matrix, various size of lipid granules, and abundant amount of extracellular matrix. The extracellular matrix were collagen fibres and ground substances and matrix vesicle. The undifferentiated cells showed smooth cytoplasmic membranes, large nuclei resembling primitive mesenchymal cells.

Mesenchymal Chondrosarcoma of the Orbit

“…1,6,23) CT characteristics included relatively clearly outlined isodense mass with moderately enhanced calcification. 2,5,9,11,20,21) MR imaging characteristics were lower than or equal to brain tissue intensity on T 1 -weighted imaging, isointensity to brain tissue on T 2 -weighted imaging, and moderate enhancement after gadolinium administration. 21) Surgical resection has been the main treatment modality for intraorbital MC ( cases of intraorbital MC, including the present case, treated with surgical removal had good outcomes if the tumors were removed completely.…”

“…14) Radical resection seems the best option, but there is no consensus on treatment protocols, including appropriate surgical procedures and the effectiveness of chemotherapy and radiotherapy. 8,9,14,20) Intraorbital MC is extremely rare, with only a few reported cases. [2][3][4][5][6][9][10][11][15][16][17][18][19][20][21][22][23] We describe a case of intraorbital MC successfully treated with intraorbital exenteration.…”

“…1,8,13,14,18,23) MC occurs mainly in young women in their twenties and thirties. 8,14,18,20) The histological features of MC are admixed figures of undifferentiated mesenchymal cells and islands of mature hyaline cartilage. 8,14,18) The mesenchymal cells are positive for CD99 and vimentin, and the chondroid tissue is positive for S-100 protein.…”

Primary mesenchymal chondrosarcoma of the orbit: Histopathological report of 3 pediatric cases

“…Congenital MCS has been reported in two studies, one of which was orbital 8, 9. On the other hand, the neoplasm has been reported in an 84-year-old lady by Shimo-Oku in 1980 10 . The mean duration of symptoms before the diagnosis was 6 months ranging from 2 weeks to 19 months 7 .…”