A case of metastatic female adnexal tumor of probable Wolffian origin

Deshimaru, Ryota; Fukunaga, Tomoko; Sato, Teiko; Morinaga, Soichiro; Takahashi, Mineo

doi:10.1016/j.gore.2014.07.001

Cited by 15 publications

(19 citation statements)

References 10 publications

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“…However, aggressive cases with local recurrence and metastasis have been reported. [17][18][19] Distinguishing benign from malignant FATWO is a challenging clinicopathologic problem. Findings proposed as suggestive of aggressive behavior include hypercellularity, cellular pleomorphism, high mitotic activity, and necrosis.…”

Section: Discussionmentioning

confidence: 99%

Paravaginal female adnexal tumor of probable Wolffian origin mimicking vaginal spindle cell epithelioma on biopsy

Yu¹,

Courteau²,

Lytwyn³

et al. 2019

CRCP

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Female adnexal tumor of probable wolffian origin (FATWO) is a tumor of low malignant potential that arises predominantly in the broad ligament, mesosalpinx, and ovarian hilus. The rarity of FATWO increases its susceptibility to misdiagnosis as other tumors, especially when it occurs at an unusual site. We report a 29-year-old woman with a 7.2 cm left paravaginal FATWO that invaded into the vaginal lumen. The initial biopsy demonstrated features suggestive of vaginal spindle cell epithelioma, but with increased Ki67 proliferation index. Pathologists should be aware that the common sieve-like architecture of FATWO may not be apparent on small biopsies, which by sampling error may demonstrate predominantly the less common spindle cell architecture. Awareness of FATWO in the differential diagnosis of paravaginal tumors may help to avoid misinterpretation as vaginal spindle cell epithelioma, a previously unappreciated pitfall in the diagnosis of FATWO.

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Section: Discussionmentioning

confidence: 99%

Paravaginal female adnexal tumor of probable Wolffian origin mimicking vaginal spindle cell epithelioma on biopsy

Yu¹,

Courteau²,

Lytwyn³

et al. 2019

CRCP

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“…The most commonly used regimen was paclitaxel and carboplatin. Gliveec was used in some cases with c-kit positive patients [ 6 ]. This is the first FATWO case to study MGMT methylation mutation changes in Korea.…”

Section: Discussionmentioning

confidence: 99%

“…There are currently 80 reported cases of FATWO. Among them, only 21 cases were found to have malignant potential, such as metastasis or recurrence [ 6 ]. Here, we report one case of malignant FATWO with epigenetic changes in O-6-methylguanine-DNA methyltransferase (MGMT) methylation.…”

Section: Introductionmentioning

confidence: 99%

A female adnexal tumor of probable Wolffian origin showing positive O-6-methylguanine-DNA methyltransferase methylation

2016

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Female adnexal tumor of probable Wolffian origin (FATWO) is a rare disease entity that arises from the mesonephric duct system. FATWO is different than other gynecological cancers in terms of embryology. Here, we describe the case of a 52-year-old woman with malignant FATWO. The patient underwent explorative laparotomy and surgical staging after a frozen section revealed malignancy. Detailed examination of the pathologic findings were consistent with FATWO. Counseling and further testing were provided to the patient to assess the risk of germline mutation and epigenetic change. An O-6-methylguanine-DNA methyltransferase gene methylation test was positive, and all other tests were normal. This is the first study to report a case of O-6-methylguanine-DNA methyltransferase methylation with FATWO in Korea.

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“…Endocrine treatment attempts with leuprorelin concurrently with chemotherapy or medroxyprogesterone acetate (MPA) were not able to prevent disease progression, despite hormone receptor positivity 14 .…”

Section: Therapymentioning

confidence: 99%

Female Adnexal Tumour of Probable Wolffian Origin (FATWO): Review of the Literature

Hübner¹,

Schwab²,

Hartmann

et al. 2019

Geburtshilfe Frauenheilkd

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FATWO (female adnexal tumour of probable Wolffian origin) denotes a rare tumour of the female adnexa which has been described in nearly 80 cases worldwide and which presumably originates in the remains of the Wolffian ducts. In 10 to 20 percent of patients, a metastasis or recurrence was seen subsequently and for this reason, a malignant potential is attributed to the FATWO. Because of the small number of cases, there is no clear therapeutic recommendation. The method of choice currently is surgical treatment with hysterectomy and adnexectomy. The benefit of radio- and chemotherapies is not clear and a small number of treatment attempts with imatinib have been made in cases of CD117 positivity or treatment attempts on an endocrine basis. This work provides an overview of the literature on epidemiology, imaging and histopathological diagnostic features as well as therapeutic options of this same tumour form.

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A case of metastatic female adnexal tumor of probable Wolffian origin

Abstract: HighlightsWe present a case of female adnexal tumor of probable Wolffian origin progressed rapidly while it is classified in LPM.This case suggests that recurrence can occur within 1 year in patients with tumor implants at initial surgery.

Cited by 15 publications

References 10 publications

Paravaginal female adnexal tumor of probable Wolffian origin mimicking vaginal spindle cell epithelioma on biopsy

Paravaginal female adnexal tumor of probable Wolffian origin mimicking vaginal spindle cell epithelioma on biopsy

A female adnexal tumor of probable Wolffian origin showing positive O-6-methylguanine-DNA methyltransferase methylation

Female Adnexal Tumour of Probable Wolffian Origin (FATWO): Review of the Literature

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