A Case of Metastatic Iris Tumor Observed With Anterior Segment Optical Coherence Tomography Before and After Radiation Therapy

Mitamura, Mizuho; Kase, Satoru; Suimon, Yuka; Ito, Takako; Ishida, Susumu

doi:10.21873/invivo.12023

Cited by 6 publications

(3 citation statements)

References 13 publications

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“…There have been 8 cases of metastatic tumor to the iris from esophageal cancer reported in 2 decades. Four cases were metastasized from adenocarcinoma [8][9][10] and 4 were from squamous cell carcinoma, [11][12][13][14] and the one had no pathological examination report. [9] Thus, it is extremely rare for esophageal squamous cell carcinoma to metastasize to the iris.…”

Section: Discussionmentioning

confidence: 99%

Iris metastasis as the initial presentation of metastatic esophageal cancer diagnosed by fine needle aspiration biopsy

et al. 2021

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Rationale: Metastasis of neoplasms to the eye is quite uncommon. In this case report, we describe a patient where primary esophageal cancer was diagnosed by fine needle aspiration biopsy (FNAB) of an iris tumor. Patient concerns: A 70-year-old male complained of redness and discomfort in the right eye. Diagnosis and interventions: The patient's right eye was diagnosed as idiopathic uveitis, and a topical steroid was administered. As vitreous opacities were observed even after topical therapy, oral prednisolone was administered. On slit-lamp examination of the right eye, an iris mass with neovascularization was seen in the anterior chamber. A metastatic tumor was suspected, and FNAB was performed. Histology revealed squamous cell carcinoma. Systemic workup revealed esophageal cancer with several metastases. Best-corrected visual acuity decreased to 20/400, and intraocular pressure was 40 mmHg in the right eye. Two iris tumors with neovascularization were present extending into the anterior chamber with posterior iris synechiae and 360 degree peripheral anterior synechiae. Intraocular pressure in the right eye was medically managed with hypotensive eye drops and oral acetazolamide. Iris metastases were treated with 40 Gray of radiation therapy and concurrent chemotherapy. Outcomes: The tumor regressed, but intraocular pressure was refractory to treatment because of 360 degree goniosynechial closure. The right eye lost light perception six months after treatment commenced, and the patient died 9 months after the onset of therapy due to multiple systemic metastases. Lessons: This is a rare case of masquerade syndrome without systemic symptoms in which FNAB of an iris tumor led to a diagnosis of metastatic esophageal squamous cell carcinoma. Although the patient lost his sight due to uncontrollable ocular hypertension, systemic chemotherapy, and radiation therapy were initially effective in the treatment of the metastatic iris tumor. As the prognosis of patients with metastatic iris tumors is poor, it is important for ophthalmologists to consider such diagnoses and conduct systemic investigations when necessary.

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Section: Discussionmentioning

confidence: 99%

Iris metastasis as the initial presentation of metastatic esophageal cancer diagnosed by fine needle aspiration biopsy

et al. 2021

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“…Anterior segment optical coherence tomography (AS-OCT) is a non-invasive tool for morphological assessment of ocular tumors involving anterior segments such as the cornea, conjunctiva, and iris with high resolution and high reproducibility. We recently reported morphological assessments of a metastatic iris tumor by AS-OCT, which revealed useful clinicopathological correlations before and after treatments [ 5 ]. We herein report a case of MC arising in the corneal limbus, in which AS-OCT was employed for clinical diagnosis and to formulate a preoperative strategy.…”

Section: Introductionmentioning

confidence: 99%

Molluscum contagiosum of the corneal limbus in an AIDS patient: a clinicopathological case report

2022

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Background Molluscum contagiosum, a pox virus infection, is likely to occur in the eyelid skin; however, corneal involvements by molluscum lesions are extremely rare. We report a case of molluscum contagiosum arising in the corneal limbus in an untreated AIDS patient, together with anterior segment optical coherence tomography (OCT) findings and histopathology of the excised tumor. Case presentation A 46-year-old man with AIDS was referred to our department for the management of an ocular lesion. Blood tests revealed an extremely low CD4+ T-cell count of 11 cells/μL, being strongly positive for anti-HIV antibody (591.36 S/CO) with a high copy number of HIV RNA (8070.0 × 100 copy/mL). Slit-lamp examination of his right eye showed a white nodule at the lower limbus. Anterior segment OCT findings of the nodule revealed a highly reflective elevated lesion, which was considered to involve the Bowman layer. The nodular lesion was excised from the limbus including the superficial corneal stroma, and then processed for histologic examination. Histopathology of the excised lesion showed acanthotic corneal epithelium containing swollen cells with eosinophilic inclusions known as molluscum bodies. He was diagnosed with molluscum contagiosum. Conclusions Anterior segment OCT findings provide useful information for morphological evaluations of and preoperative strategies against molluscum contagiosum.

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“…In recent years, based on a particular imaging mechanism (dual-beam interferometry), optical coherence tomography (OCT) imaging technology has become a high-resolution and non-contact tool in biomedical research (11)(12)(13)(14)(15). In particular, according to the principle of dynamic scattering detection of red blood cells in the vasculature, OCT angiography (OCTA), as a powerful and supplementary technology of the OCT, has the capability of visualizing microcirculation without an exogenous contrast agent (16,17).…”

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confidence: 99%

Long-term Intravital Investigation of an Orthotopic Glioma Mouse ModelviaOptical Coherence Tomography Angiography

ZHENG,

WANG,

ZHOU

et al. 2024

In Vivo

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Background/Aim: Probing brain tumor microvasculature holds significant importance in both basic cancer research and medical practice for tracking tumor development and assessing treatment outcomes. However, few imaging methods commonly used in clinics can noninvasively monitor the brain microvascular network at high precision and without exogenous contrast agents in vivo. The present study aimed to investigate the characteristics of microvasculature during brain tumor development in an orthotopic glioma mouse model. Materials and Methods: An orthotopic glioma mouse model was established by surgical orthotopic implantation of U87-MG-luc cells into the mouse brain. Then, optical coherence tomography angiography (OCTA) was utilized to characterize the microvasculature progression within 14 days. Results: The orthotopic glioma mouse model evaluated by bioluminescence imaging and MRI was successfully generated. As the tumor grew, the microvessels within the tumor area slowly decreased, progressing from the center to the periphery for 14 days. Conclusion: This study highlights the potential of OCTA as a useful tool to noninvasively visualize the brain microvascular network at high precision and without any exogenous contrast agents in vivo.Glioma is the most common primary cancer in the brain with a poor prognosis, and is characterized by microvascular proliferation (1, 2). Specifically, sufficient nutrients and metabolic substrates delivered by blood vessels are indispensable to satisfy the rapidly growing tumors (3). On the other hand, cancer cell metastasis, immune cell transportation, and anti-cancer drug delivery heavily rely on the tumor's vascular network (4). Thus, probing tumor microvascular progress in living subjects holds great 1192

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A Case of Metastatic Iris Tumor Observed With Anterior Segment Optical Coherence Tomography Before and After Radiation Therapy

Cited by 6 publications

References 13 publications

Iris metastasis as the initial presentation of metastatic esophageal cancer diagnosed by fine needle aspiration biopsy

Iris metastasis as the initial presentation of metastatic esophageal cancer diagnosed by fine needle aspiration biopsy

Molluscum contagiosum of the corneal limbus in an AIDS patient: a clinicopathological case report

Long-term Intravital Investigation of an Orthotopic Glioma Mouse ModelviaOptical Coherence Tomography Angiography

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