A case of methotrexate-associated lymphoproliferative disorder with jaw necrosis

Intraoral localized methotrexate‐associated lymphoproliferative disorders concurrent with antiresorptive agent‐related osteonecrosis of the jaw: A case report and literature review

“…Most intraoral localized MTX-LPD patients (20/22) were Japanese. 3,[20][21][22][23][24][25][26][27][28][29][30]33,35 However, the reason is unclear. Therefore, a study has been initiated jointly by three academic societies (Japan College of Rheumatology, The Japanese Society of Hematology, The Japanese Society of Pathology) in Japan.…”

“…Most intraoral localized MTX‐LPD patients (20/22) were Japanese 3,20‐30,33,35 . However, the reason is unclear.…”

“…A review of the literature revealed 22 cases of intraoral localized MTX-LPD with bone exposure, including our case (Table 1). 2,3,[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] The mean age of the patients was 73 years (range, 44-92 years), and the male to female ratio was 2:1. The mean duration of MTX treatment was 8.6 years (range, 0.6-20 years).…”