A case of mixed neuroendocrine non-neuroendocrine neoplasm of the distal bile duct with biliary intraepithelial neoplasia

Kaino, Miyuki; Kaino, Seiji; Goma, Wakana; Hideura, Eizaburo; Hitosugi, Tomoki; Harima, Yohei; Urata, Yohei; Nakamura, Yohei

doi:10.1007/s12328-020-01174-9

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Hong et al reviewed 11 cases of primary extrahepatic bile duct NEN (1 NET, 7 NEC, and 3 mixed adenocarcinoma neuroendocrine carcinoma [MANEC]) and reported that the tumors presented as nodular or intraductal growingtype lesions [8]. Kaino et al suggested that MiNEN is an admixture of exocrine and endocrine components and that its contrast pattern may be heterogeneous [9]. Therefore, in tumors with lesions with different blood flow characteristics, close examination for MiNEN may be important; however, it is difficult to differentiate MiNEN from cholangiocarcinoma based on imaging alone.…”

Section: Discussionmentioning

confidence: 99%

Mixed neuroendocrine–non-neuroendocrine neoplasm of the bile duct with long-term prognosis after neoadjuvant chemotherapy

Nakamura,

Serikawa,

Ishii

et al. 2024

Clin J Gastroenterol

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A 74-year-old man with obstructive jaundice presented with a thickened distal bile duct wall. A transpapillary forceps biopsy revealed an adenocarcinoma; however, because the tumor image was different from that of a typical cholangiocarcinoma, endoscopic ultrasound-guided fine-needle aspiration was performed on the tumor and enlarged lymph nodes. The tumor cells were positive for synaptophysin and CD56 with a Ki67 labeling index of 95%, and he was diagnosed with small cell neuroendocrine carcinoma. We diagnosed a bile duct tumor with neuroendocrine carcinoma component with lymph node metastasis. Preoperative chemotherapy for neuroendocrine carcinoma was administered because R0 resection was difficult and the risk of postoperative recurrence was high. Three courses of chemotherapy with carboplatin and etoposide resulted in marked tumor shrinkage, and radical resection was performed 3 months after diagnosis. Postoperative pathology revealed adenocarcinoma in the mucosal epithelium and small cell neuroendocrine carcinoma in the submucosa, most of which resolved with chemotherapy. Carboplatin and etoposide were resumed as adjuvant chemotherapy, and 67 months of recurrence-free survival were achieved after surgery.

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Section: Discussionmentioning

confidence: 99%

Mixed neuroendocrine–non-neuroendocrine neoplasm of the bile duct with long-term prognosis after neoadjuvant chemotherapy

Nakamura,

Serikawa,

Ishii

et al. 2024

Clin J Gastroenterol

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“…In addition, TP53 point mutation has been found in a case 12 , while the presence of microsatellite instability and alterations of genes involved in the ERBB pathway ( HMCN1 and CDH10 ) were reported in a case 13 . These results, together with the evidence that GB and EHBD NECs are frequently mixed with invasive and pre-invasive non-neuroendocrine components, and can be called mixed neuroendocrine/non-neuroendocrine neoplasms (MiNENs) 11 , 12 , 14-17 , suggest that also in these sites NEC may share common pathogenetic pathways with autoctonous adenocarcinomas, in analogy to MiNENs of other digestive and extra-digestive locations 18 , 19 .…”

Section: Primary Nens Of the Extrahepatic Bile Ducts (Ehbd) And Of The Gallbladder (Gb)mentioning

confidence: 94%

Neuroendocrine neoplasms of the biliary tree, liver and pancreas: a pathological approach

et al. 2021

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Summary Neuroendocrine neoplasms of the pancreatobiliary tract and liver are a heterogeneous group that encompass a spectrum of entities with distinct morphological, biological and clinical features. Although in the various anatomical sub-sites of this region they show specific characteristics, these tumors, as a whole, share several etiological and clinical aspects. This review systematically addresses NENs arising in the extrahepatic bile ducts, gallbladder, liver and pancreas, with the principal aim of pinpointing essential diagnostic and classification issues. In addition, the section on hepatic NENs has been expanded to include metastatic disease of unknown primary site.

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A Case of Mixed Neuroendocrine-non-neuroendocrine Neoplasm (MiNEN) of the Distal Bile Duct

HAMAZAKI,

KUISE,

TAKAHASHI

et al. 2023

Nihon Rinsho Geka Gakkai Zasshi (J Jpn Surg Assoc)

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A case of mixed neuroendocrine non-neuroendocrine neoplasm of the distal bile duct with biliary intraepithelial neoplasia

Cited by 3 publications

References 9 publications

Mixed neuroendocrine–non-neuroendocrine neoplasm of the bile duct with long-term prognosis after neoadjuvant chemotherapy

Mixed neuroendocrine–non-neuroendocrine neoplasm of the bile duct with long-term prognosis after neoadjuvant chemotherapy

Neuroendocrine neoplasms of the biliary tree, liver and pancreas: a pathological approach

A Case of Mixed Neuroendocrine-non-neuroendocrine Neoplasm (MiNEN) of the Distal Bile Duct

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