A Case of Mosquito Hypersensitivity Terminating as Malignant Histiocytosis

Mohri, Shinobu; Kawashima, Yoshiko; Uchigata, Yasuko; Seki, Hidetoshi; Okuda, Norihiko; Masuda, Shinji; R, Fukushiro

doi:10.1111/j.1346-8138.1982.tb01086.x

Cited by 19 publications

(11 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Death from malignancy, including malignant histiocytosis and lymphoma, may be based on some form of congenital immunodeficiency. There are several reports suggesting that natural killer cell lymphocytosis may have some relationship to this type of hypersensitivity and to prolonged infection of the EB virus, resulting in malignant histiocytosis (6,8,10). To reach a definite conclusion, however, further immunological studies need to be undertaken.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Quantitative Study of Specific Immunoglobulins to Mosquito Salivary Gland Antigen in Hypersensitive and Common Types of Mosquito Bite Reaction

Ohtaki

Oka

1994

The Journal of Dermatology

View full text Add to dashboard Cite

This study was designed with two purposes: first, to elucidate immunologic mechanisms in different cutaneous reactions, particularly in hypersensitivity to mosquito bites, and, second, to develop a more reliable and safer method of identifying the causative species of mosquito in severe cases. The amounts of IgG, IgG4 and IgE specific to the mosquito salivary gland extract of Aedes albopictus were determined in the sera of 116 volunteers with normal reactions, either immediate or delayed, and 4 patients with severe systemic symptoms caused by mosquito bites. Titers of IgG and IgE in the severe cases were considerably higher than in volunteers with normal reactions, but there were no differences in IgG4 titers between the two groups. These results indicate that high titers of IgG and IgE may be involved in development of systemic symptoms in severe cases and verify the possibility of in vitro tests to identify causative species of the mosquito.

show abstract

Section: Discussionmentioning

confidence: 99%

“…In addition to these common reactions, single mosquito bites have produced, in some cases, very severe reactions with systemic symptoms such as high fever, lymphoadenopathy, and hepatosplenomegaly (5)(6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

A Quantitative Study of Specific Immunoglobulins to Mosquito Salivary Gland Antigen in Hypersensitive and Common Types of Mosquito Bite Reaction

Ohtaki

Oka

1994

The Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…However, they may exhibit severe, delayed bite reactions which can appear before the malignancy has been diagnosed [14]. Recently, Japanese investigators focused attention on severe, Arthus-type mosquito hypersensitivity appearing in childhood and cLilm.inating, in many cases, in malignant histiocytosis [12,15]. Interestingly, altered cutaneous reactions to mosquito bites have also been reported in three patients with AIDS, after receiving zidovudine treatment [16].…”

Section: Abnormal Bite Reactionsmentioning

confidence: 99%

Immunology and treatment of mosquito bites

Reunala

Brummer‐Korvenkontio

Lappalainen

et al. 1990

Clin Experimental Allergy

View full text Add to dashboard Cite

Cutaneous reactions to mosquito bites are usually pruritic weals and delayed papules. Arthus-type local and systemic symptoms can also occur but anaphylactic reactions are very rare. Both clinical and experimental evidence suggest that the various bite reactions result from sensitization to the mosquito saliva injected into the skin during feeding. Recent immunoblot studies have shown both IgG- and IgE-class anti-mosquito antibodies, but their species-specificity and clinical importance is at present unknown. In addition to an Arthus-type mechanism, both cutaneous late-phase reactivity and cell-mediated immunity may be involved in the pathophysiology of delayed mosquito-bite lesions. Cutaneous sensitization to mosquito bites can be divided into five different stages ranging from the stages of immediate wealing and delayed bite papules, to the stage of non-reactivity. No desensitization treatment is generally available for mosquito allergy but it has recently been shown that cetirizine, a potent non-sedating antihistamine, is effective against the wealing and pruritus caused by mosquito bites.

show abstract

“…In 15 of these 19 patients, there was evidence of associated viral infections, including Epstein-Barr virus, adenovirus, cytomegalovirus, herpes simplex and varicella-zoster viruses. Mohri et al (14) reported a lO-year-old girl with recurrent bullae after mosquito bites. An intradermal test was positive against an extract from Culex triaeniorhynchus.…”

Section: Discussionmentioning

confidence: 99%