A case of mucus-producing cholangiocarcinoma with superficial spread.

Isogai, Masatoshi; Nimura, Yuji; Hayakawa, Naokazu; Hasegawa, Hiroshi; Asai, Masanori; Kamiya, Junichi; Maeda, Shoji; Okamoto, Katsushi; Yamase, Hiroshi; Kishimoto, Hideo; Shionoya, Shigehiko; Kato, Shingo; Hayakawa, Makoto

doi:10.5833/jjgs.19.710

Cited by 9 publications

(9 citation statements)

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“…There have been six reports of 39 patients with papillary PC 6–11. Three reports of 26 patients with complete clinical data and follow‐up were available for review (Table 4).…”

Section: Resultsmentioning

confidence: 99%

“…This tumor has a papillary growth pattern and may be associated with intraductal mucin accumulation. Twenty‐eight cases of intraductal papillary PC of the liver have been reported in the literature 6–11. Reports have suggested a less aggressive tumor biology, with potential long‐term survival, but the rarity of these tumors has limited information on outcome.…”

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confidence: 99%

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Hepatic intraductal oncocytic papillary carcinoma

Martin

Klimstra

Schwartz

et al. 2002

Cancer

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BACKGROUND There has been an increasing incidence and mortality from peripheral cholangiocarcinoma (PC) in the United States over the past 24 years. PC has been classified into two principal types, a mass‐forming type and a periductal‐infiltrating type, with a significant difference in the clinical behavior between the two. A third type, demonstrating a noninvasive intraductal growth of PC, was described as papillary PC. Rarely, papillary hepatic tumors composed of oncocytic cells have been described. Intraductal oncocytic papillary carcinomas (IOPCs) of the liver present as large, mucin‐filled, cystic lesions lined by noninvasive or focally microinvasive oncocytic tumors. METHODS From June 1999 to August 2001, three patients with hepatic IOPCs were identified in the files of the Hepatobiliary Service, Department of Surgery, and the Department of Pathology at Memorial Sloan‐Kettering Cancer Center. They form the basis of this study. We report the clinicopathologic presentation, as well as the outcome, with a review of the literature. RESULTS All three cases presented with well defined intrahepatic cystic masses ranging in size from 7.2 to 21.1 cm. The most prominent cells of the lining epithelium were columnar with oncocytic features showing abundant eosinophilic granular cytoplasm and centrally located nucleoli. All three patients underwent resection with one demonstrating local bile duct recurrence that was managed with stenting. Review of the literature has identified 39 patients with papillary PC and 2 patients with IOPC. The biology of these reported cases has been variable with overall survival better than that of nonpapillary PC patients, with recurrence in 15% of the reported cases. CONCLUSION Papillary PC is a rare type of cholangiocarcinoma that includes an interesting variant: IOPC. These tumors are predominantly found in men, who present with large (> 5 cm) mucinous cystic lesions of the bile duct. A noninvasive histology is seen, and long‐term survival may be achieved with complete resection. Invasive variants of IOPC have been reported in the literature and have a worse overall prognosis. Cancer 2002;95:2180–7. © 2002 American Cancer Society. DOI 10.1002/cncr.10934

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“…There have been six reports of 39 patients with papillary PC 6–11. Three reports of 26 patients with complete clinical data and follow‐up were available for review (Table 4).…”

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Hepatic intraductal oncocytic papillary carcinoma

Martin

Klimstra

Schwartz

et al. 2002

Cancer

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“…Of 172 cholangiocarcinomas resected at the First Department of Surgery, Nagoya University Hospital, between April 1975 and December 1994, 10 (5.8%) were “mucin‐producing cholangiocarcinoma” i.e., they produced clinically recognizable mucin. Eight of the subjects have been previously reported . The preoperative radiographic studies, intraoperative findings, and the gross and microscopic findings of resected specimens in each of the ten patients are reviewed.…”

Section: Methodsmentioning

confidence: 99%

“…Eight of the subjects have been previously reported. [1][2][3][4][5][6][7] The preoperative radiographic studies, intraoperative findings, and the gross and microscopic findings of resected specimens in each of the ten patients are reviewed.…”

Section: Methodsmentioning

confidence: 99%

Clinicopathological studies of mucin-producing cholangiocarcinoma

Shimizu

Nimura

Hayakawa

et al. 1997

J Hep Bil Pancr Surg

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Abstract:Cholangiocarcinomas that produced clinically recognizable mucin (mucin-producing cholangiocarcinomas) were studied in ten patients. These ten represented 5.8% of all cholangiocarcinomas resected at our department. All tumors arose from the intrahepatic bile ducts. Macroscopically, the ten tumors were classified as: "ductectatic type" (n --3), in which papillary tumors developed in diffusely dilated intrahepatic bile ducts; "cystic type" (n = 5), in which a large cystic tumor was present in the liver; and "intermediate type" (n = 2), characterized by a large cystic lesion and a solid mass that infiltrated the liver parenchyma. Histologically, four tumors remained localized to the mucosal layer and six invaded the fibrous layer and the liver parenchyma. Tke invasion pattern of the six invasive cancers resembled tt~at of the most common type of cholangiocarcinoma. Superficial spread of the cancer contiguous to the primary tumor was observed in four of the ten patients.

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“…Cases of MBDC reported in Japan to date in both the Japanese and English literature are summarized4,5,7,9,12,…”

Section: Discussionmentioning

confidence: 99%

Mucin-producing bile duct carcinoma originating at the hepatic hilus

Hirota

Tomioka

Ohshima³

et al. 1997

J Hep Bil Pancr Surg

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We describe a mucin-producing bile duct carcinoma that was resected and analyzed pathologically. Endoscopic retrograde cholangiography disclosed amorphous filling defects in the dilated extrahepatic bile duct, suggesting that a large amount of mucin was excreted from the tumor. An intraductal amorphous filling defect showed shape change at different examination times. Pathology examination revealed a papillary tumor which showed mucus production, in the right hepatic duct. The cut section of the resected specimen showed a protuberant papillary lesion, measuring 14 • 14 mm in diameter, forming a cystic mucous lake within the duct wall. Many cancer cells were also found in the mucous lake, the contents of which were strongly positive for mucin stain. The mucous lake developed laterally and communicated with the peribiliary glands, suggesting that the tumor had originated in these glands.

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A case of mucus-producing cholangiocarcinoma with superficial spread.

Cited by 9 publications

References 0 publications

Hepatic intraductal oncocytic papillary carcinoma

Hepatic intraductal oncocytic papillary carcinoma

Clinicopathological studies of mucin-producing cholangiocarcinoma

Mucin-producing bile duct carcinoma originating at the hepatic hilus

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