A case of multi-organ failure

Abstract

Colchicine is a commonly used drug in the treatment of gout. Gastrointestinal side effects

Colchicine in acute gout: the need for a reappraisal

“…On the light of our short-term follow-up and according with Ahlerig et al (2), we retain RALP substantially comparable with ORP regarding the clinical parameters, with some advantages of RALP in terms of finer nerve sparing, less blood loss and faster patient's recovery.…”

“…Gout is the most common cause of inflammatory arthritis in men aged over 40 years and is frequently encountered in clinical practice (1). We applaud Tahrani et al (2) on their case report highlighting an important message with the administration of colchicine in acute gout and their comprehensive discussion cautions about the intricacies in the early management of patients with acute gout. However the authors advise the recommended dose of colchicine in the British National Formulary (BNF) (2), and this suggested dose is a matter of significant concern.…”

“…We applaud Tahrani et al (2) on their case report highlighting an important message with the administration of colchicine in acute gout and their comprehensive discussion cautions about the intricacies in the early management of patients with acute gout. However the authors advise the recommended dose of colchicine in the British National Formulary (BNF) (2), and this suggested dose is a matter of significant concern. As an illustrative example; a 'Lesson of the week' BMJ publication had reported on a series of cases where adverse reactions were encountered by using higher doses of colchicine in acute gout (3), as per the recommendations of the BNF (4).…”

Kolşisin ile İlişkili Polinöropati ve Multi-Organ Yetmezliği

“…A. A. Tahrani et al report a case of bone marrow depression, multiple organ failure and death resulting from colchicine use (11). The article reports that the patient has been taking colchicine 1.5 mg/day for two weeks.…”

Is there still a place for colchicine in the treatment of acute gout?

“…All three letters were written in response to recently published papers, two of which relating to severe life‐threatening adverse effects caused by the drug. The first concerned a fatal case of multiple organ failure resulting from colchicine‐induced diarrhoea in a male of 65 (5); the second records the histories of eight cases of substantial (0.18–0.53 mg/kg) colchicine overdosage, seven of which were fatal (five suicidal; three accidental) (6). The authors of the last mentioned rightly draw attention to the narrow therapeutic index and question the need to retain colchicine in the pharmacopoea.…”