A Case of Multicentric Reticulohistiocytosis Initially Misdiagnosed as Lupus

Badlissi, Fadi; Setty, Y.; Folzenlogen, Darcy

doi:10.1097/00124743-200208000-00015

Cited by 8 publications

(4 citation statements)

References 6 publications

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“…Of the 27 individually described cases of MRH presenting with dermatomyositis-like features, 7 (26%) were associated with malignancy [5,11,14,15,22,26], which is essentially equivalent to the previously reported rate of 25% in classic MRH [1]. Therefore, having dermatomyositis-like features did not have an increased association with malignancy.…”

Section: Discussionmentioning

confidence: 68%

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Multicentric Reticulohistiocytosis with Dermatomyositis-Like Features: A More Common Disease Presentation than Previously Thought

Fett

Liu

2011

Dermatology

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Multicentric reticulohistiocytosis (MRH) is a rare form of non-Langerhans histiocytosis that presents with erosive arthritis and skin nodules. Approximately 25% of patients with MRH have an associated malignancy. Dermatomyositis is an inflammatory autoimmune condition that has also been associated with malignancy. To date, 7 cases of MRH have been reported to present with cutaneous features of dermatomyositis. We describe an eighth patient with MRH who presented with dermatomyositis-like features (V-neck erythema, shawl sign, Gottron’s papules and periungual erythema), who developed metastatic breast cancer 1 year after diagnosis. We hypothesized that clinical overlap between MRH and dermatomyositis was not as uncommon as review of the literature suggested. Careful review of the physical exam findings and photographs of the 234 papers reporting MRH revealed 27 cases of MRH with dermatomyositis-like features. Of these 27 cases, 7 (26%) were associated with a malignancy. Skin biopsies of the cutaneous features mimicking dermatomyositis revealed pathologic features of MRH. This is a descriptive analysis of published case reports. Based on a review of published case reports, MRH presenting with dermatomyositis-like features is likely fairly common. Histological examination of skin biopsies allows for disease differentiation. Differentiating MRH from dermatomyositis is important for management decisions and comorbidity screening.

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Section: Discussionmentioning

confidence: 68%

“…All patients had biopsies consistent with MRH. Using these methods, 27 cases of MRH with dermatomyositis-like features were identified (table 1) [4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27]. …”

Section: Discussionmentioning

confidence: 99%

Multicentric Reticulohistiocytosis with Dermatomyositis-Like Features: A More Common Disease Presentation than Previously Thought

Fett

Liu

2011

Dermatology

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“…Skin manifestations are usually seen as erythematous shiny, smooth papules or nodules located on the head and neck and extremities; however, dermatomyositis‐like presentation is reported in approximately 10% of patients 3 . The resemblance of the clinical presentation to other rheumatologic disorders may lead to misdiagnosis if skin biopsy is not performed 3,6,7 . Multiple shiny erythematous papules in the periungual area is suggestive of MRH, which is referred to as the “coral bead sign.” 8 MRH can also present with dermatomyositis‐like features that includes V‐neck erythema, Gottron papules, periungual erythema, and shawl sign.…”

Section: Discussionmentioning

confidence: 99%

“…3 The resemblance of the clinical presentation to other rheumatologic disorders may lead to misdiagnosis if skin biopsy is not performed. 3,6,7 Multiple shiny erythematous papules in the periungual area is suggestive of MRH, which is referred to as the "coral bead sign." 8 MRH can also present with dermatomyositis-like features that includes V-neck erythema, Gottron papules, periungual erythema, and shawl sign.…”

Section: Discussionmentioning

confidence: 99%

Multicentric reticulohistiocytosis with dermatomyositis‐like features: A case report with dermoscopy and reflectance confocal microscopy findings

2021

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Multicentric reticulohistiocytosis (MRH) is an insidious‐onset, non‐Langerhans‐cell histiocytosis (NLCH) affecting the joints and skin. Early diagnosis is important to prevent destructive arthritis and disease‐related complications. Reflectance confocal microscopy (RCM) is a technique that allows the visualization of the epidermis and superficial dermis noninvasively on a horizontal plane with quasi‐histologic images of the skin. RCM features of NLCH including Rosai‐Dorfman disease, adult xanthogranuloma (AXG), and juvenile xanthogranuloma (JXG) have been reported. However, RCM features of MRH have not been described previously. Here we present the RCM features of a case of MRH with dermoscopic and histopathologic features.

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Histiocytoses

Chu

2010

Rook's Textbook of Dermatology

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A Case of Multicentric Reticulohistiocytosis Initially Misdiagnosed as Lupus

Cited by 8 publications

References 6 publications

Multicentric Reticulohistiocytosis with Dermatomyositis-Like Features: A More Common Disease Presentation than Previously Thought

Multicentric Reticulohistiocytosis with Dermatomyositis-Like Features: A More Common Disease Presentation than Previously Thought

Multicentric reticulohistiocytosis with dermatomyositis‐like features: A case report with dermoscopy and reflectance confocal microscopy findings

Histiocytoses

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