A Case of Multiple Eruptive Dermatofibromas in a Healthy Adult

Her, Young; Ku, Sang Hyeon; Kim, Kwang Ho

doi:10.5021/ad.2014.26.4.539

Cited by 7 publications

(11 citation statements)

References 6 publications

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“…Familial cases suggesting a genetic disorder have also been reported [6]. Our review of literature revealed that 22 of 72 subjects were otherwise healthy [7].…”

Section: Discussionmentioning

confidence: 83%

Multiple eruptive dermatofibromas occuring in a patient under hemodialysis

Rejeb¹,

Dhaoui²,

Ghachem³

et al. 2016

Our Dermatol Online

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Dermatofibroma is a benign lesion of the skin, characterized by a fibroblastic proliferation. It is usually a solitary nodule, but some cases of patients diagnosed with multiple eruptive dermatofibromas have been reported. We herein describe another rare case of numerous ill-defined nodules occurring in a patient on long term-dialysis. Microscopic examination revealed typical features of dermatofibroma.

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“…Familial cases suggesting a genetic disorder have also been reported [6]. Our review of literature revealed that 22 of 72 subjects were otherwise healthy [7].…”

Section: Discussionmentioning

confidence: 83%

Multiple eruptive dermatofibromas occuring in a patient under hemodialysis

Rejeb¹,

Dhaoui²,

Ghachem³

et al. 2016

Our Dermatol Online

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“…While solitary dermatofibromas may be incidental findings, multiple dermatofibromas may be associated with systemic conditions, such as autoimmune diseases, cancer, chromosomal abnormalities, immunodeficiency, metabolic disorders; or previous therapies [1,2]. The presence of many dermatofibromas in a patient without relevant associations, as in this case, is an even less frequent situation.…”

Section: Teaching Pointmentioning

confidence: 83%

Multiple Dermatofibromas on the Legs

Salerni

Alonso

2020

Dermatol Pract Concept

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ance of new lesions to the present. The patient was otherwise healthy, and there was no previous history of trauma, autoimmune diseases, immunodeficiency or use of immunosuppressive drugs. Cutaneous examination revealed firm brownish plaques and dome-shaped papules, ranging from 5 mm to 25 mm in diameter, with positive lateral dimple sign. The total number of lesions counted was greater than 180. Dermoscopy was consistent with dermatofibroma in all lesions (Figure 1).

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“…This variant, called multiple eruptive dermatofibromas (MEDF), was first described in 1970 [9] and is usually defined as the appearance of 5 to 8 DF within a period of four months [10]. MEDF are estimated to occur in less Dermatology Online Journal || Case Presentation than 1% of patients with DF [11] and are associated with an underlying systemic condition in at least two-thirds of the cases [12][13][14]. In 80% of the cases, this underlying condition is related to some immunologic disturbance [12].…”

Section: Case Discussionmentioning

confidence: 99%

“…MEDF are estimated to occur in less Dermatology Online Journal || Case Presentation than 1% of patients with DF [11] and are associated with an underlying systemic condition in at least two-thirds of the cases [12][13][14]. In 80% of the cases, this underlying condition is related to some immunologic disturbance [12].…”

Section: Case Discussionmentioning

confidence: 99%

“…In other words, it is possible that in the genesis of MEDF a putative antigen is involved, which cannot be cleared from the skin by the suppressed immune system, leading to the development of these characteristic skin lesions [17]. In this way, MEDF have been described as a possible manifestation of a subjacent condition associated with immunosuppression [12]. Pregnancy has traditionally been considered "the greatest paradox of all the laws of tissue transplantation," as a human fetal allograft survives and growths in a potentially hostile immunological environment [15].…”

Section: Case Discussionmentioning

confidence: 99%

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