A case of pediatric ovarian dysgerminoma associated with high serum levels and positive immunohistochemical staining of neuron-specific enolase

Laparoscopic Management of Ovarian Dysgerminoma Presenting with Acute Abdomen Caused by Adnexal Torsion in a 17-Year-Old Girl

“…5 There are few reports on adnexal torsion due to ovarian dysgerminoma in the literature. 6,7 However, since subacute abdominal pain and a palpable pelvic mass are the most common symptoms and sign in a girl or young women presenting with a germ cell tumor as a result of rupture, torsion or hemorrhage, 1 the presence of malignancy should be considered when a patient with solid adnexal tumor presents with acute abdomen. Laparotomic surgery is supposed to be the treatment of choice in the majority of cases similar to the present case, especially under emergency settings.…”

“…5 There are few reports of adnexal torsion due to ovarian dysgerminoma in the literature. 6,7 With advances in laparoscopic surgical procedures and the development of surgical equipment, the advantages of laparoscopic treatment over laparotomy for adnexal diseases occurring in young girls have been reported. 8 This form of minimally invasive surgery provides potential benefits for improved cosmetic appearance, shorter hospital stay, reduced postoperative pain, and earlier postoperative return to daily activities.…”

Pediatric ovarian dysgerminoma with highly elevated serum neuron‐specific enolase

“…and Yoshida et al . reported similar cases of dysgerminoma, in which serum NSE increased prior to surgery but normalized immediately after resection . In these seven reported cases of dysgerminoma with high serum NSE, the median value before tumor resection was 64 ng/mL (range, 24–199.5 ng/mL).…”

“…In patients with dysgerminoma, the ovarian counterpart of testicular seminoma, serum lactic dehydrogenase (LDH; mainly isozymes 1 and 2) and cancer antigen 125 (CA‐125) are usually elevated, whereas human chorionic gonadotropin (hCG) and placental alkaline phosphatase (PLAP) are rarely elevated. α‐Fetoprotein, however, is normal . Serial measurement of these markers can be useful for monitoring disease.…”

“…Serial measurement of these markers can be useful for monitoring disease. Few reports describe neuron‐specific enolase (NSE) as a tumor marker for dysgerminoma …”