A Case of Phototoxicity due to Hydrochlorothiazide

Han, K. D.; Oh, Chang-Wug; Yoon, Tae‐Jin; Kim, Tae‐Heung

doi:10.5021/ad.1998.10.4.289

Cited by 1 publication

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“…The Korean Ministry of Food and Drug Safety approved pelubiprofen for relieving the symptoms of osteoarthritis in 2007 and approved expanded indications for the relief of back pain in 2010. In these three cases of NSAIDs-associated ESS including present case, in contrast to chemotherapy-associated ESS, the lesions were distributed in sun-exposed areas such as face and neck, but not flexural areas, and epidermal changes such as erosion or necrosis were not observed, which implies that the reaction was not due to non-specific toxic damage of medication9. Several NSAIDs are known to have phototoxic reaction.…”

Section: Discussionmentioning

confidence: 56%

Eccrine Squamous Syringometaplasia Associated with Pelubiprofen Therapy

Huh

Yoo

et al. 2017

Ann Dermatol

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Eccrine squamous syringometaplasia (ESS) is a histologically distinctive skin eruption occurring predominantly in acral or intertriginous areas presenting as erythematous macules, papules or patches. The etiology of ESS remains unclear, but it is usually reported in patients receiving chemotherapy for various malignant neoplasms. To date, only two cases of ESS associated with non-steroidal anti-inflammatory drugs (NSAIDs), which has distinctive clinical features and pathogenesis, have been reported in the literature. Herein, we report a rare and interesting case of ESS associated with pelubiprofen, a recently developed NSAID, which appeared after pelubiprofen therapy and resolved spontaneously after discontinuing the medication.

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Section: Discussionmentioning

confidence: 56%