A case of platypnea-orthodeoxia syndrome caused by the interaction between the presence of corrected transposition of the great arteries and patent foramen ovale

Platypnoea-orthodeoxia syndrome: novel cause for a known condition

“…Platypnoea and orthodeoxia have been described in several cardiopulmonary disorders categorised as11 Cardiovascular : Intracardiac shunts,12 patent foramen ovale (PFO),5 13 atrial septal defect (ASD) and atrial septal aneurysm,14–16 bioprosthetic tricuspid valve stenosis,17 transposition of the great arteries,18 eosinophilic endomyocardial disease,19 constrictive pericarditis,20 21 atrial myxoma,22 aortic aneurysm,23 24 aortic elongation,25 pericardial disease, right ventricular remodelling, a prominent Eustachian valve, aortic dilation26 and pericardial effusion 27

Pulmonary : Postpneumonectomy,28 amiodarone-induced pulmonary toxicity,29 recurrent pulmonary emboli,5 adult respiratory distress syndrome,30 pulmonary AVM,31 pulmonary hypertension in obstructive sleep apnoea syndrome,32 true vascular lung shunts,2 bronchogenic carcinoma,33 interstitial fibrosis,34 pulmonary embolism,35 chronic obstructive pulmonary disease (COPD),36 37 emphysema, pneumonectomy16 38–39 and cryptogenic fibrosing alveolitis 40

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“…Cardiovascular : Intracardiac shunts,12 patent foramen ovale (PFO),5 13 atrial septal defect (ASD) and atrial septal aneurysm,14–16 bioprosthetic tricuspid valve stenosis,17 transposition of the great arteries,18 eosinophilic endomyocardial disease,19 constrictive pericarditis,20 21 atrial myxoma,22 aortic aneurysm,23 24 aortic elongation,25 pericardial disease, right ventricular remodelling, a prominent Eustachian valve, aortic dilation26 and pericardial effusion 27…”

Platypnea orthodeoxia: a ‘laid-back’ case of dyspnoea

“…Eventually, platypnea and orthodeoxia due to an extracardiac shunt were diagnosed. Reported aetiologies to consider Cardiovascular–intracardiac shunts,1 bioprosthetic tricuspid valve stenosis,2 transposition of the great arteries,3 eosinophilic endomyocardial disease,4 constrictive pericarditis,5 atrial myxoma6 aortic aneurysm 7

Pulmonary postpneumonectomy,8 amiodarone-induced pulmonary toxicity9 recurrent pulmonary emboli,10 adult respiratory distress syndrome 11

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“…Cardiovascular–intracardiac shunts,1 bioprosthetic tricuspid valve stenosis,2 transposition of the great arteries,3 eosinophilic endomyocardial disease,4 constrictive pericarditis,5 atrial myxoma6 aortic aneurysm 7…”