A case of pleomorphic renal cell carcinoma producing G-CSF.

Takahashi, Hirotaka; Andoh, Tomoko; Katoh, Tsuyoshi; Uehara, Tomoko; Satow, Nobuo; Takeda, Bin

doi:10.5795/jjscc.35.576

Cited by 6 publications

(3 citation statements)

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“…In 1977, Asano et al reported that the presence of G–CSF–producing tumors was proved by increased neutrophil production and elevated G-CSF activity in the blood of mice transplanted with tumor tissues of patients with lung cancer having neutrophilia [ 1 ]. Since then, G–CSF–producing tumors have been reported in various organs, such as the liver, kidney, and gallbladder; however, lungs are the most common as primary sites [ 2 ]. A study reported that nearly all cases of G–CSF–producing lung cancer are non-small cell cancer and large-cell carcinoma is the most common [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

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G–CSF–producing left lung squamous cell carcinoma positive for ROS1 rearrangements completely resected after neoadjuvant radiation chemotherapy: A case report

Samejima

Ose

Sakurai

et al. 2022

Respiratory Medicine Case Reports

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Section: Discussionmentioning

confidence: 99%

“…Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic cytokine that promotes neutrophil production. G–CSF–producing tumors are featured with neutrophilia without infection induced by overproducing G-CSF, and most patients with the tumors show an aggressive clinical course and poor prognosis [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

G–CSF–producing left lung squamous cell carcinoma positive for ROS1 rearrangements completely resected after neoadjuvant radiation chemotherapy: A case report

Samejima

Ose

Sakurai

et al. 2022

Respiratory Medicine Case Reports

View full text Add to dashboard Cite

“…Takahashi et al [11] reported that, for the diagnosis of G-CSF-producing tumors, the confirmation of increased serum G-CSF levels and positive immunostaining with an anti-G-CSF antibody were sufficient. Among patients with G-CSF-producing tumors, some may present with fever or have elevated C-reactive protein levels because of other cause of leukocytosis [12].…”

Section: Discussionmentioning

confidence: 99%

A Case of Squamous Cell Carcinoma of the Lung That Produced Granulocyte Colony-Stimulating Factor and Interleukin-6

Takeuchi

Yamamoto

Naba

2013

Case Reports in Medicine

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A 77-year-old woman visited our institution complaining of general fatigue. Chest radiography revealed masses in the upper and middle lung fields. Pathological findings for an endoscopic biopsy specimen revealed squamous cell carcinoma. High-grade fever developed and blood analyses revealed sustained elevated white blood cell count and C-reactive protein levels. Cytokine production by tumor cells was suspected; both serum granulocyte colony-stimulating factor (117 pg/mL; normal: <57.5 pg/mL) and interleukin-6 (83.5 pg/mL; normal: <2.41 pg/mL) levels were high. Immunohistochemical examination of biopsy specimens showed positive staining with antigranulocyte colony-stimulating factor and anti-interleukin-6 monoclonal antibodies. Diagnosis of a tumor that produced granulocyte colony-stimulating factor and interleukin-6 was established. The patient was administered best supportive therapy since she was not eligible for surgical treatment because of her poor respiratory function. She died from interstitial pneumonia exacerbation two months after this diagnosis. We present a female with squamous cell carcinoma of the lung that produced granulocyte colony-stimulating factor and interleukin-6.

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A Case of Lung Histiocytic Sarcoma That Produced Granulocyte Colony-stimulating Factor

Kamimura

Matsuoka

Kashima

et al. 2022

JJLC

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━━ Background. Histiocytic sarcoma (HS) is extremely rare, and few studies have reported paraneoplastic syndromes with HS. We encountered a case of lung HS expressing granulocyte colony-stimulating factor (G-CSF). Case. A 50-year-old woman who presented with fatigue was referred to our hospital for a further examination of leukocytosis. Chest computed tomography (CT) revealed a 28×22×43-mm nodule in the left upper lung, and positron emission tomography (PET)/CT showed an abnormally high uptake of fluorodeoxyglucose (FDG) in the nodule. The level of serum G-CSF was abnormally high (183.2 pg/ml), so we suspected a G-CSF-producing tumor of the lung and performed left upper lobectomy with mediastinal lymph node dissection for the diagnosis and treatment. An immunohistochemical evaluation indicated HS of the lung, and the tumor cells were partly positive for anti-human G-CSF antibody. The final pathological diagnosis was lung HS expressing G-CSF. Postoperatively, the patient has remained relapse-free for 12 months without adjuvant chemotherapy. Conclusion. We experienced an extremely rare case of lung HS with the expression of G-CSF. Currently, the patient is still alive with no recurrence, although further close follow-up is essential.

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A case of pleomorphic renal cell carcinoma producing G-CSF.

Cited by 6 publications

References 0 publications

G–CSF–producing left lung squamous cell carcinoma positive for ROS1 rearrangements completely resected after neoadjuvant radiation chemotherapy: A case report

G–CSF–producing left lung squamous cell carcinoma positive for ROS1 rearrangements completely resected after neoadjuvant radiation chemotherapy: A case report

A Case of Squamous Cell Carcinoma of the Lung That Produced Granulocyte Colony-Stimulating Factor and Interleukin-6

A Case of Lung Histiocytic Sarcoma That Produced Granulocyte Colony-stimulating Factor

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