A Case of Podocytic Infolding Glomerulopathy with Diabetes Mellitus, Nephrotic Range Proteinuria and Positive Anti-PLA2R in Serum

Abstract

Podocytic Infolding Glomerulopathy (PIG) is a new rare pathological entity characterized by invagination of the podocyte cell membrane into the glomerular basement membrane in the kidney biopsy. Discovered over a decade ago, PIG is a podocytopathy detected by electron microscopy that is still unclear as to which autoimmune, hereditary or acquired diseases it is most closely associated with. We report histopathologic findings typical of PIG in a diabetic patient with nephrotic range proteinuria and phospholipase A2 receptor antibodies title found in serum. He was conservatively treated with ACEis and responded with mild decrease in proteinuria.