A Case of Polymicrobial, Gram-Negative Pulmonic Valve Endocarditis

Bekker, Tatiana Md; Govind, Anusha; Weber, Devin

doi:10.1155/2019/6439390

Cited by 4 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Liver abscess and urinary tract infection are the most common source when bacteremia is present 36 . Mortality rates vary depending on the pathogen, virulence factors, complications and the valve involved, reaching up to 49% in one article 6 , 37 . Urgent surgical interventions as a first-choice treatment is recommended for uncontrolled infection to prevent complications, including heart failure and embolic events 35 , 38 .…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of infective endocarditis due to pandrug-resistant Klebsiella pneumoniae with ceftazidime-avibactam and aztreonam

Alghoribi

Alqurashi

Okdah

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Pandrug-resistant (PDR) K. pneumoniae refractory to conventional treatment has been reported worldwide, causing a huge burden on the healthcare system, patient safety and the economy. K. pneumoniae is a prominent opportunistic pathogen causing hospital-acquired and community-acquired infections, but is rarely associated with infective endocarditis. Currently, there are sparse data guiding the optimal regimen when commonly used antibiotics fail, notably for the treatment of endocarditis infections. Here we report our experience in treating a 40-year-old female with PDR K. pneumoniae infection of cardiovascular implantable electronic device (CIED) and right-sided infective endocarditis. Initial susceptibility testing of the incriminated pathogen showed an apparent susceptibility to colistin but the prolonged course of colistin, gentamicin and meropenem did not resolve the infection. However, the synergistic combinations of aztreonam with ceftazidime-avibactam was able to overcome resistance and clear the infection rapidly. Genome sequencing showed that the PDR K. pneumoniae isolate belongs to the international high-risk clone ST14. The isolate harbored genes encoding NDM-1, OXA-48, CTX-M-14b, SHV-28 and OXA-1, explaining resistance to all β-lactams, including carbapenems. It carried the armA gene conferring resistance to all clinically important aminoglycosides and had alterations in GyrA, ParC and MgrB, explaining resistance to ciprofloxacin and colistin.

show abstract

Section: Discussionmentioning

confidence: 99%

Successful treatment of infective endocarditis due to pandrug-resistant Klebsiella pneumoniae with ceftazidime-avibactam and aztreonam

Alghoribi

Alqurashi

Okdah

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Organismos Gram-negativos estão menos relacionados a esse tipo de patologia por se incorporarem menos e com maior dificuldade nas válvulas cárdicas. A EI também pode ocorrer por infecção fúngica, acometendo em maior intensidade indivíduos que utilizam drogas injetáveis e imunossuprimidos, sendo os agentes mais prevalentes a Candida e Aspergillus spp 9 .…”

Section: Revisão De Literaturaunclassified

Profilaxia antibiótica para prevenção da Endocardite bacteriana: uma revisão de literatura

Bernardino,

Boás,

Maia

et al. 2023

Braz. J. Hea. Rev.

View full text Add to dashboard Cite

O endocárdio, tecido que reveste as estruturas internas do coração, quando colonizado por bactérias ou fungos patogênicos, pode levar à endocardite infecciosa (EI), uma condição grave. Há correlações entre procedimentos odontológicos e a EI, levantando debates sobre profilaxia antibiótica. O objetivo do estudo é avaliar a eficácia de antibióticos na profilaxia de pacientes com cardiopatias. Foi realizada uma revisão de literatura que avaliou a eficácia da administração pré-operatória de antibióticos em pacientes com cardiopatias submetidos. Os estudos considerados foram publicados entre 2018 e 2022 em português, inglês e espanhol, com descritores científicos "Antibiotic Prophylaxis", "Surgery, Oral" and "Endocarditis, Bacterial” e “Heart Valve Diseases”, relacionados ao tratamento odontológico com antibióticos. A EI afeta principalmente homens idosos e tem alta incidência no Brasil, se manifestando com sintomas como febre, calafrios e pode levar a consequências graves. Os principais fatores de risco incluem idade avançada, próteses cardíacas, corticoesteroides e cardiopatias, com Staphylococcus como o agente bacteriano mais comum. Pacientes com alto risco de desenvolver EI após procedimentos cirúrgicos incluem aqueles com comorbidades, histórico de cardiopatias, doenças cardíacas complexas e derivações pulmonares reconstruídas precisam realizar antibioticoprofilaxia. Pacientes com risco mínimo não necessitam. A antibioticoprofilaxia em procedimentos odontológicos é viável e prudente em pacientes com cardiopatias, prevenindo a endocardite bacteriana e oferecendo segurança. Desse modo, este trabalho busca elucidar o papel dos antibióticos no contexto da profilaxia como prevenção a endocardite bacteriana.

show abstract

Pulmonary valve infective endocarditis

Sharma

Malavia

2021

Annals of Pediatric Cardiology

View full text Add to dashboard Cite

Background and Objectives: Infective endocarditis (IE) involving the native pulmonary valve (PV) is extremely rare, with no data in Indian literature. The objective of this communication is to describe the clinical and diagnostic characteristics, underlying risk factors, microbiological features, and management of PVIE. Methods: This is a retrospective analysis of 8 cases of PVIE managed in a tertiary care center from 1992 to 2020. Results: PVIE was observed in 8 patients with underlying congenital cardiac malformation (Group A, 6 Patients) and in patients with central venous catheter (Group B, 2 patients). All the patients had prolonged febrile illness accompanied by right heart failure 4 (50%), septic pulmonary emboli 2 (25%), and pulmonary regurgitation 3 (37.5%). Trans-thoracic echocardiography demonstrated the vegetations, whereas computed tomography of chest diagnosed pulmonary emboli in 2 (25%), and pulmonary artery aneurysm in 1 (12.5%) patient. The early mortality was extremely high (5, 62.5%). Delayed diagnosis, fulminant septicemia, and multi-organ failure resulted in unfavorable outcomes. Conclusions: IE of the native PV is a rare and potentially lethal illness. Diagnosis should be considered in any febrile patient with an underlying congenital defect, central venous line, bacteremia, and comorbidities. Multi-modality imaging should be utilized to enhance the diagnostic yield and detect complications promptly.

show abstract

A Case of Polymicrobial, Gram-Negative Pulmonic Valve Endocarditis

Cited by 4 publications

References 11 publications

Successful treatment of infective endocarditis due to pandrug-resistant Klebsiella pneumoniae with ceftazidime-avibactam and aztreonam

Successful treatment of infective endocarditis due to pandrug-resistant Klebsiella pneumoniae with ceftazidime-avibactam and aztreonam

Profilaxia antibiótica para prevenção da Endocardite bacteriana: uma revisão de literatura

Pulmonary valve infective endocarditis

Contact Info

Product

Resources

About