A Case of Primary Cutaneous Basal Cell Carcinosarcoma

Suzuki, Hiromi; Hashimoto, Akira; Saito, Ryoko; Izumi, Mitsuru; Aiba, Setsuya

doi:10.1159/000492525

Cited by 9 publications

(6 citation statements)

References 7 publications

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“…Suzuki et al . published a review of 94 cases of CCS between 1972 and 2016, and showed a 4.3% recurrence and metastatic rate for BCCS 6 . This case highlights the potential for aggressive clinical behaviour, recurrence and metastasis despite having definitive Mohs micrographic surgery as the initial treatment.…”

Section: Discussionmentioning

confidence: 81%

A rare cutaneous tumour

Sykes

Aronson

Tallon

et al. 2022

Clinical and Experimental Dermatology

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Section: Discussionmentioning

confidence: 81%

A rare cutaneous tumour

Sykes

Aronson

Tallon

et al. 2022

Clinical and Experimental Dermatology

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“…As previously reported, carcinosarcomas may present in various shapes and sizes; therefore, management depends on clinical and histological features [8]. There has been no consensus on definitive margins for excision for cutaneous primary manifestations, as reports describe a range from 0.5-3.5 cm margins [5,9,19,20]. As these defects can be large and in a prominently visible location, it is important for dermatologists to consider referral to plastic surgery for adequate reconstruction.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Carcinosarcoma: A Small Case Series and Review of the Literature of a Rare Skin Tumor

Song

Wallace

Sheikh

et al. 2020

Cureus

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Carcinosarcomas are composed of epithelial and mesenchymal elements and primarily present within visceral organs. Despite being potentially aggressive, they are a rare diagnosis in the skin, and few manifestations have been reported to date. In this report, we describe two separate cases of carcinosarcoma presenting as nonhealing scalp wounds. Patient A: a 57-yearold male with a nonhealing skin lesion of ten years successfully treated with wide-local excision and local ortichochea flap reconstruction. Patient B: a 75-year-old female that presented with a painless, slow-growing hemorrhagic mass of 7 years invading the skull and dura ultimately requiring craniectomy and free-tissue transfer with anterolateral thigh flap. Cutaneous carcinosarcomas have more favorable outcomes due to low metastatic rates likely due to earlier detection, but delayed presentation can be fatal. Histopathological analysis is critical for determining diagnosis and prognosis. Adequate reconstruction after wide base excision varies and follows the reconstructive ladder/elevator ranging from primary closure up through free-tissue transfer. With cutaneous manifestations of carcinosarcoma seldom reported in the literature, it is our hope that reporting unusual instances such as this will raise awareness and allow for earlier diagnoses, treatments, and reconstructions.

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“…Genetic and molecular evidences too favor it, with overlapping molecular changes common in both tumor components including P63 and PTCH1 mutations (P63 indicating epithelial derivation of metaplastic carcinomas and a mutation in the PTCH1 gene in the hedgehog pathway in BCC PCCS). [ 7 8 9 10 ] Other hypotheses are: origin from two separate progenitor cells (multiclonal/collision/convergence hypothesis) leading to a collision tumor of two unique neoplasms,[ 1 ] and the composition hypothesis proposing the mesenchymal component as a pseudosarcomatous reaction to the epithelial malignancy. [ 11 ]…”

Section: Discussionmentioning

confidence: 99%

A Rare Cutaneous Malignancy: A Primary Cutaneous Carcinosarcoma with Adnexal Epithelial Component (Trichoblastic Carcinosarcoma) of Left Temporal Region

Nagose,

Ingle,

Chandak

et al. 2024

Indian Journal of Dermatology

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Primary cutaneous carcinosarcoma (PCCS) is a rare cutaneous biphasic tumour with just 120 cases being reported till date. The epithelial component trichoblastic carcinoma/ malignant trichoblastoma (trichoblastic carcinosarcoma) is even rarer, so is the present case. An eighty years old male patient presented with a rapidly progressing ulceroproliferative nodular growth on the left temporal region. The incisional biopsy showed primary cutaneous carcinomasarcoma (PCCS). IHC showed epithelial and stromal component marked exclusively for pancytokeratin (AE1/AE3) CK5&6/ p40 and vimentin respectively. Both components were immunopositive for D2-40 and immunonegative for BerEP4/ S100/ Melan A/ MITF, thus final diagnosis given was Trichoblastic carcinosarcoma. Wide excision of the lesion with local rotation flap and skin grafting (thigh skin) was done. Patient remains disease free after four years also. Present case thus highlights the importance of HPE, IHC and early surgery for excellent prognosis of PCCS.

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A Case of Primary Cutaneous Basal Cell Carcinosarcoma

Cited by 9 publications

References 7 publications

A rare cutaneous tumour

A rare cutaneous tumour

Cutaneous Carcinosarcoma: A Small Case Series and Review of the Literature of a Rare Skin Tumor

A Rare Cutaneous Malignancy: A Primary Cutaneous Carcinosarcoma with Adnexal Epithelial Component (Trichoblastic Carcinosarcoma) of Left Temporal Region

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