A case of primary cutaneous aspergillosis in a renal transplant recipient

Soft Tissue Abscess Caused by Aspergillus Fumigatus in an Immunosuppressive Patient

“…Risk factors for invasive aspergillosis include neutropenia, glucocorticoid therapy, advanced acquired immunodeficiency syndrome, chronic granulomatous disease, hematopoietic stem cell or solid-organ transplantation (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). Aspergillus infections are also common in premature and newborn infants hospitalized in intensive care according to the literature (20,21).…”

“…In the following years cutaneous aspergillosis cases with renal transplantation, heart transplantation, pancreatic transplantation were published. To our knowledge there was a limited number of primary cutaneous aspergillosis cases in solid organ transplant patients (6,(8)(9)(10)(11). We presented a primary cutaneous aspergillosis case report with heart transplant recipient in this article.…”

Acral manifestations of fungal infections

“…Important histological findings are 45° dichotomous branching of hyaline, septate hyphae. 101,102 Phaeohyphomycosis is the other deep fungal infection that has non-specific cutaneous manifestations like papules, pustules, nodules and ulcers. Causative organisms should be identified with laboratory tests.…”

Skin infections in organ transplant recipients

“…In the literature individual reports of cutaneous aspergillosis, for example due to direct inoculation or hematogenous spread, exist. Skin manifestations were often unspecific and present among others, as hemorrhagic bullae or erythematous plaques [7, 49, 50]. While fluconazole is ineffective in Aspergillus infections, some Aspergillus species have developed resistance to amphotericin B [43].…”

“…In a recent case report of primary cutaneous aspergillosis in a kidney transplant recipient, neither week‐long itraconazole nor liposomal amphotericin B administration led to healing of skin lesions. Only surgical excision and month‐long antifungal therapy with liposomal amphotericin B resulted in the patient being disease‐free [49]. Only rarely have cutaneous manifestations of other fungi such as Cryptococcus neoformans, Exophiala jeanselmei, Wangiella dermatitidis or Alternaria species been reported [7].…”