“…1 Pachydermia, which predominantly affects the face and limbs, is the most frequent skin symptom. [1][2][3] The principal complications concern the joints, with arthralgia, arthritis, hydrarthrosis and haemarthrosis, which may occur symmetrically in the major joints and in the small joints of the hands and feet. 4 Radiologically, acro-osteolysis, periosteal changes of short, long and flat bones, and ossification of ligaments and interosseous membranes have been reported.…”