A case of primitive neuroectodermal tumor of the ovary

Kuk, Jin Yi; Yoon, So Yean; Kim, Min Ji; Lee, Jeong Won; Bae, Duk Soo

doi:10.5468/kjog.2012.55.10.777

Cited by 3 publications

(4 citation statements)

References 15 publications

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“…The treatment for ES includes surgical resection, chemotherapy, and radiotherapy. However, despite this multi-modal therapeutic approach, overall survival for the patients remains low, as reported in studies by Mulsow et al 35 and Abboud et al 36 Kuk et al 30 reported an overall survival in ovarian ES patients ranging from 10.8 to 36 months. Moreover, owing to the rarity of ovarian ES, standard effective treatment guidelines do not exist.…”

Section: Discussionmentioning

confidence: 98%

Bilateral primary ovarian Ewing sarcoma recurring as left submandibular lymphadenopathy diagnosed on cytology

Malik,

Madan,

Agrawal

et al. 2024

Autops Case Rep

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Ewing sarcoma (ES) is a highly malignant and aggressive small round-cell tumor originating from primitive neuroepithelium and mesenchymal stem cells. It is usually seen in children and adolescents with a male predilection and a preponderance to occur in long bones. Although skeletal/soft tissue ES is encountered in clinical practice, primary ES of the genital tract, particularly bilateral primary ovarian ES, is highly uncommon, with only a handful of cases reported worldwide. Ovarian ES is occasionally reported to involve para-aortic and pelvic lymph nodes in advanced stages. Still, cervical lymph node metastasis from ovarian ES is an infrequent clinical occurrence and, when present, indicates a worse prognosis. Here, we present an intriguing case of bilateral peripheral primary ovarian ES in an adult female, recurring as metastasis in the left submandibular lymph node. This case underlines the importance of keeping metastasis from ES as a possible differential while diagnosing metastatic small round cell tumors in peripheral lymph nodes. It also highlights the usefulness of a minimally invasive diagnostic modality of fine needle aspiration cytology and cell block preparation with applied ancillary techniques of immunohistochemistry and confirmatory molecular testing by fluorescence in-situ hybridization (FISH), for an accurate and quick diagnosis of such entities. The cytological diagnosis of our patient helped in the prompt and early initiation of chemotherapy without requiring any invasive procedure.

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Section: Discussionmentioning

confidence: 98%

Bilateral primary ovarian Ewing sarcoma recurring as left submandibular lymphadenopathy diagnosed on cytology

Malik,

Madan,

Agrawal

et al. 2024

Autops Case Rep

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“…PNETs are uncommon entities especially for the female genital tract and the ovaries are the most common location ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ) . It seems that the exact age for non-skeletal ES is not clear, but cases in the literature were seen between the second and third decades of the life.…”

Section: Discussionmentioning

confidence: 99%

“…The distinction between ES of the ovary and other tumors is made through immunohistochemistry studies. As seen in Table 2 , ( 12 , 13 , 14 , 15 , 24 ) on immunohistochemistry, diffuse membranous positivity for MIC2 (CD99), CD56 (neural cell adhesion molecule), HMW CK and FL1 led to the consideration of PNETs. Negativity for epithelial markers such as CK, EMA, desmin, and WT-1 led to the consideration of desmoplastic small round cell tumors (SRCTs).…”

Section: Discussionmentioning

confidence: 99%

Primitive neuroectodermal tumor of genital tract in hysterectomized patient: A case report

Yakıştıran

Taşkın

Ersöz

et al. 2018

tjod

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Primitive neuroectodermal tumors are high-grade malignant neoplasms. These are uncommon entities for the female genital tract. The treatment, management and follow-up period of Ewing’s tumors are not well-defined because of their rarity in the genital tract. Surgical debulking is the mainstay treatment in all cases. After debulking surgery, patients receive chemotherapy and/or radiotherapy and there is a relation between disease stage and survival. Herein, we present a case of ovarian primitive neuroectodermal tumor with a review of previously reported cases.

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“…Various literatures on ES focus mainly on rare sites such as craniofacial, hands and feet, gastrointestinal organs, and spinal masses. There have been case reports on ES on the ovary, [3] kidney, [4] and phalanges of hand. [5]…”

Section: Introductionmentioning

confidence: 99%

Atypical Presentation of Ewing’s Sarcoma

Yogi

Mani

Singh

et al. 2019

Indian Journal of Medical and Paediatric Oncology

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Background: Ewing's sarcoma (ES) is an osseous malignancy of small round blue cells which may manifest even in soft tissue. It is the second most common primary tumor of bone in childhood. The common areas of occurrence are the diaphyses of femur followed by tibia, humerus, pelvis, and clavicle. However, there are many unusual presentations of ES on the basis of the site, e.g., craniofacial bones, paravertebral mass, and visceral organs. Chemotherapy with radiation therapy and cytoreductive surgery/limb salvage surgery is the mainstay treatment along with a strict patient compliance and counseling, critically being important for long-term survival. This study depicts presentations of ES who either presented with some unusuality at the time of diagnosis or developed peculiar features uncharacteristic of ES during their course of treatment. Context: This study provides an insight into the patterns of unusual presentation of ES and prognosis of such patients with current line of management. Multiple sites of metastases have a very poor dismal outlook. Aims: This study purports the importance of considering ES as a systemic disease rather an osseous malignancy and reviews the pattern of unusual sites of presentation. Setting and Design: This observational study was carried out in the Department of Radiotherapy, Gandhi Medical College, Bhopal. Only patients with unusual patterns of metastases were included in the study cohort. Materials and Methods: We systematically reviewed patients with confirmed and immunohistochemistry-proven ES from July 2014 to July to 2017. A total of 69 patients were registered within the time frame. Of the 69 patients, 36 (52.2%) were males and 33 (47.8%) were females. Of the 11 (16%) unusual presentations, 8 were males and 3 were females. The mean age of presentation was 22.5 (3-52 years). All patients received chemotherapy as per treatment guidelines. Each patient was individually followed up and metastatic workup was performed in a systematic manner. Statistical Analysis: Since the pattern of metastasis was observed, no significant statistical analysis was required for this study. Results: Of the 11 patients, six succumbed during the course of treatment, one patient was lost to follow-up, while four patients are on regular follow-up. Of the six patients who succumbed, four had multiple metastases at the time of presentation to our outpatient department, while the other two patients had paraspinal ES with paraplegia. Two patients, one male and one female, had associated comorbidities with spherocytosis and bronchial asthma. The youngest patient was a 3-year-old child with paraspinal ES, while the oldest was a 52-year-old with extraosseous ES of the right thigh who presented with lung, liver, and supraclavicular metastases. Conclusion: In our study, pattern of metastases determined the patients' survival. Those patients who presented with multiple metastases at the time of presentation had a very poor prognosis, with death occurring within 2-3 months. The chemotherapy protocols were neither...

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A case of primitive neuroectodermal tumor of the ovary

Cited by 3 publications

References 15 publications

Bilateral primary ovarian Ewing sarcoma recurring as left submandibular lymphadenopathy diagnosed on cytology

Bilateral primary ovarian Ewing sarcoma recurring as left submandibular lymphadenopathy diagnosed on cytology

Primitive neuroectodermal tumor of genital tract in hysterectomized patient: A case report

Atypical Presentation of Ewing’s Sarcoma

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