A Case of Pseudogout Following Zoledronic Acid Administration

Abstract

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A Rare Case of Acute Calcium Pyrophosphate Deposition Disease Following Zoledronic Acid Infusion

“…The literature search identified nine reported cases of CPPD disease secondary to BP therapy. From the reported cases, three were due to zoledronic acid [ 13 , 14 ], two due to pamidronate [ 8 , 11 ], two due to etidronate disodium [ 7 , 10 ], one due to alendronate [ 9 ], and one due to neridronic acid [ 12 ]. In the reported cases, the age of individuals ranged from 63 to 84 years old, except in two cases that occurred in 47-year-old and 53-year-old individuals.…”

“…Nine cases of CPPD disease secondary to BP therapy have been reported to date, with only three cases due to zoledronic acid infusion [ 7 - 14 ]. This case report describes a rare onset of acute CPPD disease following zoledronic acid infusion for the treatment of osteoporosis.…”

A case of pseudogout attack after zoledronic acid treatment in primary hyperparathyroidism

“…[ 5 ] There are limited cases of PG triggered by BP treatment given for osteoporosis in the literature,[ 5 ] and three of such cases developed after ZA. [ 3 , 5 ] Inf luenza-like symptoms, such as fatigue, fever, arthralgia, and myalgia, have been frequently described after the administration of IV ZA. However, if there are significant signs of arthritis such as redness, warmth, swelling, as in our case, PG should be considered.…”

“…However, if there are significant signs of arthritis such as redness, warmth, swelling, as in our case, PG should be considered. [ 3 ] In PG, the wrist, ankle, knee, shoulder, and hip joints can be affected. In suspected cases, radiological imaging of the joint and microscopic examination of the joint fluid is diagnostic.…”

“…[ 2 ] In the literature, PG formation due to bisphosphonate (BP) infusion performed to treat osteoporosis has been described in only one case. [ 3 ] In this report, we present a case of PG that developed when zoledronic acid (ZA) infusion was administered to treat refractory hypercalcemia due to primary hyperparathyroidism (PHP).…”