A Case of Pseudothrombotic Microangiopathy Associated with Pernicious Anemia

Wathieu, Henri; Bateman, Kristin M

doi:10.1007/s11606-020-06588-2

Cited by 4 publications

(1 citation statement)

References 23 publications

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“…Pernicious anemia (PA) is an autoimmune disease secondary to chronic atrophic gastritis leading to vitamin B12 deficiency [ 1 ]. The diagnosis of PA is often confirmed by the presence of anti-intrinsic factor antibodies, which, despite their low sensitivity, are highly specific [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Pernicious Anemia and Vitamin B12 Deficiency Presenting As Pseudothrombotic Microangiopathy and Developing Secondary Thrombocytopenia After Treatment: A Case Report

Abosheaishaa¹,

Nassar²,

Ghallab³

et al. 2022

Cureus

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Pernicious anemia (PA) is an autoimmune disease secondary to chronic atrophic gastritis leading to vitamin B12 deficiency. Rarely, some patients may develop advanced hematological complications that mimic those of thrombotic thrombocytopenic purpura (TTP). Differentiating these conditions is crucial because they require different management. We present a case of a 68-year-old male who presented with generalized weakness, fatigue, and shortness of breath. This patient had anemia, thrombocytopenia, and a markedly deficient serum level of vitamin B12. The symptoms initially mimicked those associated with TTP, but the activity of ADAMTS 13 was normal. A diagnosis of pseudo-TTP has been made due to vitamin B12 deficiency resulting from PA with reactive thrombocytosis. Ultimately, vitamin B12 deficiency pseudo-TTP should be considered a differential diagnosis for therapy refractory TTP because of its different management strategies ranging from parenteral Vitamin B12 in PA patients with highly favorable outcomes to more advanced treatment with less favorable outcomes in TTP patients.

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Section: Introductionmentioning

confidence: 99%

Pernicious Anemia and Vitamin B12 Deficiency Presenting As Pseudothrombotic Microangiopathy and Developing Secondary Thrombocytopenia After Treatment: A Case Report

Abosheaishaa¹,

Nassar²,

Ghallab³

et al. 2022

Cureus

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A Case of Pernicious Anemia with Concurrent Beta-Thalassemia Minor

Yuan,

Huang,

Yao

et al. 2024

JBM

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Vitamin B 12 is essential for various bodily functions, and its deficiency may cause hematological manifestations. We report a case of a previously healthy 65-year-old female who was admitted to our hospital with reduced sense of taste and painful tongue. The serum level of vitamin B 12 was decreased. However, her complete blood count did not show any evidence of macrocytosis, instead, her mean corpuscular volume was low. Gene sequencing indicated an β-thalassemia minor and that probably masked the megaloblastic features of vitamin B 12 deficiency.

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Pseudomicroangiopatía trombótica como presentación infrecuente de deficiencia de vitamina B12. Serie de casos

Fernández Castañeda,

Araúz Valdés

2024

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La vitamina B12 es un cofactor que forma parte de la síntesis de ADN, formación de glóbulos rojos y determinante de funciones neurológicas. Su deficiencia genera manifestaciones variadas. La pseudomicroangiopatía trombótica se caracteriza por anemia hemolítica microangiopática y trombocitopenia asociada a eritrocitos dismórficos secundario a deficiencia severa de vitamina B12. Con una incidencia aproximada de 2.5%. A menudo es confundida con púrpura trombocitopénica trombótica y tratada como tal. La reposición con cianocobalamina produce mejoría inmediata de los síntomas, sin la necesidad de otros tratamientos. Describimos tres casos de pacientes hospitalizados en un hospital general en la ciudad de Panamá, República de Panamá. Dos varones y una mujer sin antecedentes patológicos que debutan con síndrome anémico, datos de anemia hemolítica microangiopática y deficiencia severa de vitamina B12. Con mejoría clínica posterior a la reposición con cianocobalamina.

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A Case of Pseudothrombotic Microangiopathy Associated with Pernicious Anemia

Cited by 4 publications

References 23 publications

Pernicious Anemia and Vitamin B12 Deficiency Presenting As Pseudothrombotic Microangiopathy and Developing Secondary Thrombocytopenia After Treatment: A Case Report

Pernicious Anemia and Vitamin B12 Deficiency Presenting As Pseudothrombotic Microangiopathy and Developing Secondary Thrombocytopenia After Treatment: A Case Report

A Case of Pernicious Anemia with Concurrent Beta-Thalassemia Minor

Pseudomicroangiopatía trombótica como presentación infrecuente de deficiencia de vitamina B12. Serie de casos

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