A case of psoriasis vulgaris with peripheral blood eosinophilia, parallelling the psoriasis area and severity index (PASI) score

Sueki, Hirohiko; Nakada, Tsutomu; Iijima, Masafumi

doi:10.1111/j.1365-2230.2004.01566.x

Cited by 4 publications

(7 citation statements)

References 6 publications

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“…A recent report of a case with psoriasis vulgaris, who showed peripheral blood eosinophilia paralleling PASI scores, provided a further evidence for the role of eosinophils in the pathogenesis of psoriasis. The patient described in this report was treated with tacalcitol ointment, indicating that treatment modalities seems to be less important in lowering the blood eosinophil counts, instead, the improvement of psoriasis is directly related with this laboratory result 4 …”

Section: Discussionmentioning

confidence: 76%

“…The patient described in this report was treated with tacalcitol ointment, indicating that treatment modalities seems to be less important in lowering the blood eosinophil counts, instead, the improvement of psoriasis is directly related with this laboratory result. 4 Eosinophils are cells that mainly reside in tissues. It is estimated that for every one blood eosinophil, there are 100 tissue eosinophils.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, there are some reports pointing out that psoriasis may be associated with eosinophilia 2,3 . A recent article reporting a patient with plaque‐type psoriasis and a high blood eosinophil count that paralleled the psoriasis area and severity index (PASI) score during treatment, has supported the relation of eosinophils with psoriasis 4 …”

Section: Introductionmentioning

confidence: 91%

“…2,3 A recent article reporting a patient with plaque-type psoriasis and a high blood eosinophil count that paralleled the psoriasis area and severity index (PASI) score during treatment, has supported the relation of eosinophils with psoriasis. 4 Erythrodermic psoriasis (EP) is a severe variant of psoriasis characterized by extensive erythema and desquamation involving virtually the entire body surface. Generalized pustular psoriasis (GPP) is another serious form of psoriasis, characterized by widespread erythema on almost the entire skin, followed by pustulation.…”

Section: Introductionmentioning

confidence: 99%

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Peripheral blood eosinophilia in association with generalized pustular and erythrodermic psoriasis

At¹,

Göktay

Yaşar

2007

Acad Dermatol Venereol

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Peripheral blood eosinophilia in association with generalized pustular and erythrodermic psoriasis

At¹,

Göktay

Yaşar

2007

Acad Dermatol Venereol

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“…Eosinophila was reported as one of the haematological disorders in psoriasis [23,24], which is a secondary type of eosinophilia. Cationic protein is eosinophil toxin.…”

Section: Introductionmentioning

confidence: 99%

Adenosine Deaminase, Malondialdehyde, Total Antioxidant Capacity and Eosinophil Cationic Protein in Patients with Erythroderma

Alobaidi¹,

Alsamarai²

2013

J Invest Biochem

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Background: Psoriatic erythroderma may occur in relation to withdrawal of systemic or topical steroids, and its pathogenesis is unclear. Objective: To investigate serum Adenosine deaminase (ADA) activity in patients with erythroderma and its correlation to malondialdehyde (MDA), total antioxidant capacity (TAC) and eosinophil cationic protein (ECP). Patients and methods: 26 patients with erythroderma referred to dermatology clinic in Tikrit Teaching Hospital were included in the study after giving informed consent. The study was approved by the ethical committee of Tikrit University College of Medicine. Twenty five healthy volunteers, without clinical, laboratory or histological evidence of any disease, were included in the study as control group. Blood samples were collected and analyzed for serum ADA, MDA, TAC and ECP at the time of inclusion in the study and after complete improvement following methotrexate treatment course. Results: Mean [±SD] serum ADA activity, MDA, and ECP levels at the time of inclusion in the study were significantly higher than that following methotrexate treatment and control group. Serum TAC pretreatment means value was lower than that following treatment, and control group. Serum ADA levels before treatment was significantly positively correlated with MDA serum levels, ECP serum levels and gender. In addition, ADA serum levels were significantly negatively correlated with TAC serum levels. ESR was significantly correlated with ADA, MDA, ECP serum levels and negatively with TAC. Conclusion: ADA serum activity and serum levels of MDA, ECP and TAC may be used to predict disease response to treatment and prognosis.

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Retrospective Analysis of 397 Dermatoses Inpatients Associated with Blood Eosinophilia

Zhao,

Tian,

Gao

et al. 2023

CCID

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Background: Blood eosinophilia is often associated with various dermatoses, such as atopic eczema, urticaria, drug eruption, bullous pemphigoid, and hypereosinophilic syndrome (HES). Differential diagnosis is very challenging due to the similarities of clinical and pathological characteristics.Purpose: To investigate and analyze the clinical characteristics of dermatoses associated with blood eosinophilia (DABE) to further optimize disease management. Patients and Methods:We conducted a retrospective analysis on 397 DABE patients with blood absolute eosinophil count (AEC) greater than or equal to 0.5×10 9 /L. Clinical characteristics, laboratory values, treatment course, and associated diagnoses were evaluated. All DABE patients were grouped based on the severity of eosinophilia as mild group (0.5 ≤ AEC×10 9 /L < 1.5), moderate group (1.5 ≤ AEC×10 9 /L < 3), and severe group (AEC×10 9 /L ≥ 3). Results: Our study revealed three distinct patterns: (1) Mild eosinophilia associated with localized skin lesions, atopic history, mildly elevated total serum IgE level, diagnosed with eczema/dermatitis, and frequent antihistamines use. ( 2) Moderate eosinophilia has the characteristics of both mild group and severe group. (3) The severe eosinophilia group had a high proportion of elderly people without atopic history, but with acute onset, generalized skin lesions, and high level of lactate dehydrogenase, and the majority of them were diagnosed with systemic diseases (HES or tumor). Conclusion:We summarize the clinical rules of dermatoses associated with blood eosinophilia, hoping to facilitate the diagnosis and treatment for patients.

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A case of psoriasis vulgaris with peripheral blood eosinophilia, parallelling the psoriasis area and severity index (PASI) score

Cited by 4 publications

References 6 publications

Peripheral blood eosinophilia in association with generalized pustular and erythrodermic psoriasis

Peripheral blood eosinophilia in association with generalized pustular and erythrodermic psoriasis

Adenosine Deaminase, Malondialdehyde, Total Antioxidant Capacity and Eosinophil Cationic Protein in Patients with Erythroderma

Retrospective Analysis of 397 Dermatoses Inpatients Associated with Blood Eosinophilia

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