A Case of Pulmonary Adenocarcinoma with Sarcomatous Elements Initially Manifested as a Submucosal Tumor of the Stomach

Fukuda, Takahiro; Ohnishi, Yoshihisa; Katagiri, Jiro; Ohnuki, Keizo; Tachikawa, Shinzo

doi:10.1111/j.1440-1827.1992.tb03252.x

Cited by 6 publications

(3 citation statements)

References 18 publications

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“…Therefore, whenever a submucosal tumor composed of carcinomatous and sarcomatous components is found in the gastrointestinal tract, the lungs should be examined as a possible primary site. 8 In summary, in this study, we found that PC of the lung has distinctive clinicopathologic features and a poorer outcome than other NSCLCs. Massive coagulation necrosis was identified as a histologic prognostic factor for a poorer outcome of PC of the lung.…”

Section: Discussionmentioning

confidence: 48%

Pleomorphic Carcinoma of the Lung

Mochizuki¹,

Ishii²,

Nagai³

et al. 2008

American Journal of Surgical Pathology

186

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Pleomorphic carcinoma (PC) of the lung is rare, and it is classified as a subtype of sarcomatoid carcinoma of the lung in the World Health Organization histologic classification of lung tumors. In this study, 70 cases of PC surgically resected were reviewed to identify its clinicopathologic characteristics. There were 57 men and 13 women, and their mean age was 66 years (range: 29 to 80 y). Sixty-eight tumors contained identifiable epithelial components, and the other 2 consisted of spindle cells and giant cells alone. An adenocarcinoma component was found in 34 cases, a squamous cell carcinoma component in 13, and a large cell carcinoma component in 40. The overall survival rate and disease-free survival rate were 36.6% and 40.7%, respectively, and both rates were significantly lower than for other nonsmall cell lung carcinomas. When the PC patients were divided into 3 groups according to the predominant epithelial component, an adenocarcinoma group, squamous cell carcinoma group, and large cell carcinoma group, there were no significant differences in the overall survival rate and median survival time between the 3 groups. Univariate analysis revealed that advanced stage (stage III), mediastinal lymph node metastasis, lymphatic permeation, and histologically diagnosed massive coagulation necrosis (>25% of the tumor) predicted poorer disease-free survival. Multivariate analysis showed that massive necrosis alone was an independent prognostic factor. We concluded that PC should be considered as an aggressive disease and massive necrosis should be routinely reported and used as a factor in clinical assessments.

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Section: Discussionmentioning

confidence: 48%

Pleomorphic Carcinoma of the Lung

Mochizuki¹,

Ishii²,

Nagai³

et al. 2008

American Journal of Surgical Pathology

186

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“…Fukuda et al reported a case of pulmonary adenocarcinoma with sarcomatous elements initially manifested as a submucosal tumour of the stomach. However, autopsy revealed spindle cell variants of pulmonary adenocarcinoma [25]. An immunohistochemical study and the presence of a transitional zone are important for the diagnosis of primary or metastatic tumours.…”

Section: Discussionmentioning

confidence: 99%

Treatment for Leiomyosarcoma of the Inferior Vena Cava Complicated with Lung Adenocarcinoma: A Case Report and Literature Review

Liu

Wei

et al. 2021

Preprint

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Background: Leiomyosarcoma originating from the inferior vena cava (IVC) is a very rare malignancy. We searched the databases and did not find similar cases of leiomyosarcoma of the IVC with lung adenocarcinoma. Here, we report a patient with IVC leiomyosarcoma and lung adenocarcinoma.Case report: The patient, a 38-year-old Chinese female, presented to the general department with a history of intermittent right upper abdominal pain for 18 months. Contrast-enhanced computed tomography (CT) showed a tumour of IVC (3.4*2.7 cm) extending to the renal veins. In addition, chest CT showed a tumour in the left lung lobe. Then, the patient underwent surgery to resect the IVC tumour and partial lung. The patient received Gefitinib Tablets treatment 250 mg per day for 18 months during the perioperative period. The examination of the patient showed lung recurrence at the 18th month after partial pneumonectomy. So the patient again received thoracoscopic wedge pneumonectomy, and it was confirmed to be metastasis of IVC tumour. The patient received daily 12 mg treatment with Anlotinib after the last operation. Regular outpatient follow-up showed that there was no obvious recurrence and metastasis as of April 2021 (6 months after operation).Conclusions: It is difficult to diagnose and treat patients with IVC leiomyosarcoma and lung adenocarcinoma in a timely manner. Surgery is still an effective treatment for patients with IVC leiomyosarcoma and lung adenocarcinoma at present.

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“…Spindle cell variants of pulmonary adenocarcinoma in metastatic lesions have been reported. These reports concluded that the metastasis exclusively composed of spindle cells was misdiagnosed as leiomyosarcoma (2,3). Small intestinal occlusion by metastatic tumors is treated conservatively (4).…”

Section: Introductionmentioning

confidence: 99%

Synchronous Primary Adenocarcinoma of the Lung and Leiomyosarcoma of the Small Intestine.

et al. 2000

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The occurrence of synchronous epithelial cancer of the lung and leiomyosarcoma of the small intestine is rare. We report here the case of a 62-year-old manwith adenocarcinoma of the lung in clinical stage IIIB (T4N0M0). After two courses of chemotherapy (cisplatin, 80 mg/m2 and mitomycin C, 8 mg/m2) the patient developed symptoms of a small bowel obstruction. Palliative surgical resection was performed and a leiomyosarcomaof the small intestine was found and defined by an immunohistological study. The resection ameliorated the patient's symptoms. The patient died of disseminated adenocarcinoma 26 months following chemotherapy. (Internal Medicine 39: 655-658, 2000) Key words: leiomyosarcoma of the small intestine, pulmonary adenocarcinoma, spindle cells of metastatic lung cancer, synchronous tumor

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A Case of Pulmonary Adenocarcinoma with Sarcomatous Elements Initially Manifested as a Submucosal Tumor of the Stomach

Cited by 6 publications

References 18 publications

Pleomorphic Carcinoma of the Lung

Pleomorphic Carcinoma of the Lung

Treatment for Leiomyosarcoma of the Inferior Vena Cava Complicated with Lung Adenocarcinoma: A Case Report and Literature Review

Synchronous Primary Adenocarcinoma of the Lung and Leiomyosarcoma of the Small Intestine.

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