A Case of Pulmonary Pleomorphic Carcinoma Associated with Humoral Hypercalcemia of Malignancy Successfully Treated with Carboplatin+Paclitaxel+Bevacizumab Combination Therapy

Pulmonary pleomorphic carcinoma (PPC) is a rare disease with a poor prognosis. Most patients with PPC are refractory to chemotherapy, whereas good responses to platinum‐based chemotherapy in combination with the anti‐angiogenesis agent bevacizumab have been reported. An 82‐year‐old man was diagnosed with PPC with a clinical stage of T3N0M0, coincident with primary lung adenocarcinoma in an early stage. We chose single‐agent chemotherapy with docetaxel as an initial treatment, but both the primary adenocarcinoma and two PPC lesions in the right lung were enlarged after one treatment cycle. We subsequently started treatment with ramucirumab and docetaxel, and thereafter, the disease showed a good partial response. Here, we report the first case of advanced PPC that was effectively treated with chemotherapy and the anti‐VEGFR‐2 antibody ramucirumab. These observations suggest a potential therapeutic strategy for patients with PPC.

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Effective combined therapy with ramucirumab for advanced pulmonary pleomorphic carcinoma

Nishioka

Kaneko

Yamada

et al. 2018

Respirology Case Reports

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A case of pulmonary pleomorphic carcinoma difficult to distinguish from pulmonary hematoma

Kobayashi

Ishida

Sakamaki

2022

The Journal of the Japanese Association for Chest Surgery

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A Case of Pulmonary Pleomorphic Carcinoma Associated with Humoral Hypercalcemia of Malignancy Successfully Treated with Carboplatin+Paclitaxel+Bevacizumab Combination Therapy

Abstract: Background.Case. Conclusion.JJLC.

Cited by 2 publications

References 12 publications

Effective combined therapy with ramucirumab for advanced pulmonary pleomorphic carcinoma

Effective combined therapy with ramucirumab for advanced pulmonary pleomorphic carcinoma

A case of pulmonary pleomorphic carcinoma difficult to distinguish from pulmonary hematoma

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