A case of pulmonary tumor thrombotic microangiopathy following lymphedema on the lower extremities

Shiraiwa, Yuri; Taniguchi, Yoshihito; Hyoudou, Mari; Shiba, Aya; Aga, Masaharu; Miyazaki, Kazuhito; Hamakawa, Yusuke; Misumi, Yuki; Agemi, Yoko; Shimokawa, Tsuneo; Hasegawa, Chie; Hayashi, Hiroyuki; Okamoto, Hiroaki

doi:10.1016/j.rmcr.2022.101631

Cited by 3 publications

(1 citation statement)

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“…The search identified 48 eligible clinical articles with 59 cases of PTTM reported nationally and internationally, the remaining 14 articles were excluded due to recurrence or as they were review articles. Among them, 9 Chinese PTTM articles [13–21] were reported 16 cases; 39 English PTTM articles [1,22–59] were reported 43 cases.…”

Section: Literature Review Resultsmentioning

confidence: 99%

Pulmonary tumor thrombotic microangiopathy: Two case reports and literature review

Ma,

Gao,

Wang

et al. 2024

Medicine

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Rationale: Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare but serious complication in patients with malignancy; its main manifestation includes acute pulmonary hypertension with severe respiratory distress. More than 200 cases have been reported since it was first identified in 1990. PTTM accounts for approximately 0.9% to 3.3% of deaths due to malignancy, but only a minority of patients are diagnosed ante-mortem, with most patients having a definitive diagnosis after autopsy. Patient concerns: Two middle-aged women both died within a short period of time due to progressive dyspnea and severe pulmonary hypertension. Diagnoses: One patient was definitively confirmed as a gastrointestinal malignant tumor by liver puncture biopsy pathology. Ultimately, the clinical diagnosis was pulmonary tumor thrombotic microangiopathy. Interventions: The patient was treated symptomatically with oxygen, diuresis, and anticoagulation, while a liver puncture was perfected to clarify the cause. Outcomes: Two cases of middle-aged female patients with rapidly progressive pulmonary hypertension and respiratory failure resulted in death with malignant neoplasm. Lessons: PTTM has a rapid onset and a high morbidity and mortality rate. Our clinicians need to be more aware of the need for timely diagnosis through a targeted clinical approach, leading to more targeted treatment and a better prognosis.

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Section: Literature Review Resultsmentioning

confidence: 99%