A Case of “Pure” Preeclampsia With Nephrotic Syndrome Before 15 Weeks of Gestation in a Patient Whose Renal Biopsy Showed Glomerular Capillary Endotheliosis

Imasawa, Toshiyuki; Nishiwaki, Tetsuji; Nishimura, Motonobu; Shikama, Nobuaki; Matsumura, Ryutaro; Nagai, Masaaki; Soyama, Akiko; Koike, Kentaro; Kitamura, Hiroshi; Joh, Kensuke

doi:10.1053/j.ajkd.2006.05.024

Cited by 24 publications

(21 citation statements)

References 24 publications

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“…Preeclampsia not associated with these disorders before 20 weeks of gestation is considered to be rare. This would seem to be an accurate assertion, as a literature search identified only 4 published cases [10][11][12][13]. Clinical and pathologic characteristics of these cases and the present case are summarized in Table 1.…”

Section: Discussionmentioning

confidence: 70%

Preeclampsia before 20 weeks of gestation: a case report and review of the literature

et al. 2014

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The occurrence of preeclampsia before 20 weeks of gestation is rare and usually associated with trophoblastic diseases or antiphospholipid syndrome. Here, we report a case of preeclampsia before 20 weeks of gestation in the absence of the aforementioned disorders. A healthy 30-year-old nulliparous woman presented with new onset of hypertension and proteinuria at 18 weeks of gestation. Fetal ultrasound did not reveal any abnormalities. Empirical steroid treatment was initiated based on a tentative diagnosis of underlying renal disease. The clinical course of the disease was progressive despite steroid treatment and the fetus died in utero 8 days after the initiation of treatment. Following delivery, a renal biopsy was performed and provided a diagnosis of preeclampsia. All symptoms resolved postpartum. This report demonstrates that preeclampsia may occur before 20 weeks of gestation and should always be considered in the differential diagnosis of pregnant women with new onset of hypertension with proteinuria. Previous published cases are summarized briefly.

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Section: Discussionmentioning

confidence: 70%

Preeclampsia before 20 weeks of gestation: a case report and review of the literature

et al. 2014

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“…In patients with hypertension and nephrotic syndrome, 11 of 13 (85%) patients undergoing renal biopsy were found to have pre-clampsia (83). Imasawa et al report a case of nephrotic syndrome attributed to pre-eclampsia at 15 weeks gestation diagnosed by clinical features and renal biopsy (84), however, the International Society for the Study of Hypertension in Pregnancy define pre-eclampsia as the onset of de novo hypertension and proteinuria after 20 weeks (85). Glomerular endotheliosis, the pathognomonic histological lesion of pre-eclampsia, is characterised by endothelial cell oedema, diffuse cellular proliferation, splitting of the GBM and capillary lumen narrowing.…”

Section: Nephrotic Syndromementioning

confidence: 99%

Disentangling the effects of climate, topography, soil and vegetation on stand-scale species richness in temperate forests

Zellweger

Braunisch

Morsdorf

et al. 2015

Forest Ecology and Management

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“…Numerous case reports describe second trimester intrauterine death or termination of pregnancy with resolution of nephrotic syndrome post-partum. 35,38,[42][43][44] McLigeyo et al 45 reported 5 cases of nephrotic syndrome in early pregnancy with successful fetal outcomes, but two maternal deaths occurred within 5 years of delivery. In 13 women with nephrotic syndrome and known renal disease, 4 pregnancies ended in therapeutic termination, 1 with preterm delivery and 8 completed successfully at term.…”

Section: Nephrotic Syndromementioning

confidence: 95%

Glomerulonephritis and the Nephrotic Syndrome in Pregnancy

Hall

Brunskill

2010

Fet. Matern. Med. Rev.

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Glomerulonephritis (GN) may be manifest clinically in several ways. It may be asymptomatic and associated with only minor urinary dipstick abnormalities, GN may present with one of the classic renal nephritic or nephrotic syndromes, or may be associated with progressive chronic kidney disease with hypertension and the gradual development of uraemia, or it may present with fulminating life threatening illness with severe acute kidney injury. The development of GN may indicate a primary renal limited disease, or may be secondary in association with systemic diseases such as systemic lupus erythematosus (SLE), myeloma, infections or diabetes. Although immunological abnormalities underlie the development of many forms of GN, precise pathogenic mechanisms remain unclear and diagnostic labels may simply reflect a description of the glomerular histological changes observed (Table 1).

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A Case of “Pure” Preeclampsia With Nephrotic Syndrome Before 15 Weeks of Gestation in a Patient Whose Renal Biopsy Showed Glomerular Capillary Endotheliosis

Cited by 24 publications

References 24 publications

Preeclampsia before 20 weeks of gestation: a case report and review of the literature

Preeclampsia before 20 weeks of gestation: a case report and review of the literature

Disentangling the effects of climate, topography, soil and vegetation on stand-scale species richness in temperate forests

Glomerulonephritis and the Nephrotic Syndrome in Pregnancy

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