A case of purpura fulminans caused by Hemophilus influenzae complicated by reversible cardiomyopathy

Endo, Akira; Shiraishi, Atsushi; Aiboshi, Junichi; Hayashi, Yoshihiko; Otomo, Yasuhiro

doi:10.1186/2052-0492-2-13

Cited by 15 publications

(4 citation statements)

References 15 publications

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“…16 Several studies have documented that its mortality is extremely high and most survivors have poor outcomes and require amputation. 17 Acute infectious purpura fulminans is the most common form of purpura fulminans. Rickettsia infection associated with purpura fulminans is recorded rarely, and seen only in R.rickettsii, R.australis, R.conorii, israelensis and probably indica .…”

Section: Discussionmentioning

confidence: 99%

Fatal Rickettsia Japonica Infection Complicating Disseminated Intravascular Coagulation in Yichang, China

Gao¹,

Li²,

Zhou³

et al. 2022

IDR

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Background Severe complications may cause a fatal or disabling outcome in patients with Rickettsia japonica infection but are poorly understood. Methods We identified 11 patients with only Rickettsia japonica infection with metagenomics next generation sequencing (mNGS) during April to November 2021 at Yichang Central People’s Hospital, China. Clinical data were obtained through review of medical records. Results Most patients realized that they had symptoms about one or two days after being bitten. Fever (91%), pulmonary effusion (91%), rash or erythema (100%), abnormal urine (100%), neutropenia (100%), lymphopenia (100%), and thrombocytopenia (100%) were the most common clinical signs. Six severely ill patients were admitted to the intensive care unit and five had mild symptoms. Systemic manifestations such as vomiting (83%), neurological manifestations (100%), and disseminated intravascular coagulation (100%) were more frequently observed in the severe cases, 33.3% of whom developed purpura fulminans requiring amputation or skin graft, and 16.6% died two days after admission. Some patients experienced sequelae. Conclusion Our study found that patients with critical Rickettsia japonica infection complicating disseminated intravascular coagulation had high risk of poor outcome.

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Section: Discussionmentioning

confidence: 99%

Fatal Rickettsia Japonica Infection Complicating Disseminated Intravascular Coagulation in Yichang, China

Gao¹,

Li²,

Zhou³

et al. 2022

IDR

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“…10,14 Haemophilus influenzae is a very uncommon cause of bacterial meningitis and vas-culopathy in adults. 10,18 Staphylococcus aureus can be associated with bacteremia and vasculopathy, but community-acquired meningitis and purpura are rarely caused by this organism. 19 N. gonorrhoeae bacteremia can be associated with vasculopathy, but it would be unusual for this organism to cause meningitis 20 ; also, given the reported lack of sexual activity in this patient, this diagnosis is unlikely.…”

Section: Bacterial Causes Of Meningitismentioning

confidence: 99%

Case 11-2015

Manian¹,

Alame²

2015

N Engl J Med

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Pr esentation of C a seDr. Anant Mandawat (Medicine): A 28-year-old woman was seen in the emergency department of this hospital because of headache, fever, and a rash.The patient had been well until the morning of the day of admission, when she awoke with a severe generalized headache. The headache worsened with movement, was not relieved by acetaminophen or ibuprofen, and was accompanied by nausea and one episode of nonbloody, nonbilious emesis. The patient returned to sleep and awoke again several hours later with diffuse myalgias; her temperature was 37.7°C. At that time, she also noted a rash on her abdomen, chest, and right arm; the lesions were small, red, flat, nonpruritic, and nonpainful. She described these symptoms to her father, a physician, who advised her to go to the emergency department of this hospital.On arrival at the emergency department, the patient reported that the nausea had resolved and that mild neck stiffness had developed. She had had bacterial meningitis at 9 years of age, with symptoms similar to those of the current illness. She had no history of otitis media, sinusitis, pneumonia, or skin infections. She had a remote history of hospitalization after a motor vehicle accident. Ten months before the current illness, she had had an episode of nephrolithiasis with spontaneous passage of a renal stone. She also had a history of anxiety. Her medications were citalopram and a combined estrogen-progestin oral contraceptive. Immunizations were up to date and reportedly included vaccination against Neisseria meningitidis. She had no known allergies. She lived alone, worked as a lawyer, and had not recently traveled outside New England or had exposure to sick persons. She had a new boyfriend but was not currently sexually active. She did not smoke or use illicit drugs, and she rarely consumed alcohol. Her parents lived nearby; she had had contact with their two dogs but had not had any recent tick bites, mosquito bites, or exposure to other animals. There was no family history of immunodeficiency or autoimmune disease.On examination, the patient was alert and oriented to person, place, and time. The temperature was 37.3°C, the pulse 92 beats per minute, the blood pressure 122/68 mm Hg, the respiratory rate 18 breaths per minute, and the oxygen saturation 100% while she was breathing ambient air. She had scattered petechiae on From the Departments of Medicine (F.A.M.) and Pathology (D.A.), Massachusetts General Hospital, and the Departments of Medicine (F.A.M.) and Pathology (D.A.), Harvard Medical School -both in Boston.

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“…1 Numerous pathogenic infections have been associated with SCM. [2][3][4][5][6] To our knowledge, there are no published reports on Aspergillus as a cause of septic cardiomyopathy, so we performed the first case report.…”

Section: Introductionmentioning

confidence: 99%

Extracorporeal Membrane Oxygenation in Septic Cardiomyopathy Caused by Aspergillus Infection: The First Case Report

Wu,

Shen,

et al. 2024

IDR

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Septic cardiomyopathy (SCM) is often associated with bacterial infections but also occurs with infections with viruses such as influenza and spirochetes, including syphilis. However, there has been no systematic investigation into whether Aspergillus infections can cause septic cardiomyopathy. We report on such a case for the first time in a patient without immunodeficiency. Therefore, clinicians should be concerned with septic cardiomyopathy caused by some atypical or rare pathogens when admitting such patients.

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A case of purpura fulminans caused by Hemophilus influenzae complicated by reversible cardiomyopathy

Cited by 15 publications

References 15 publications

Fatal Rickettsia Japonica Infection Complicating Disseminated Intravascular Coagulation in Yichang, China

Fatal Rickettsia Japonica Infection Complicating Disseminated Intravascular Coagulation in Yichang, China

Case 11-2015

Extracorporeal Membrane Oxygenation in Septic Cardiomyopathy Caused by Aspergillus Infection: The First Case Report

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