A case of pyoderma gangrenosum possibly associated with sunitinib treatment

Ueharaguchi, Yuri; Kabashima, Kenji; Sasahashi, Makiko; Matsuda, Ayumu; Matubara, Kunihiko; Matsui, Miho

doi:10.1111/j.1365-4632.2011.04952.x

Cited by 15 publications

(8 citation statements)

References 2 publications

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“…Cases of drug‐induced PG were mainly gathered from PubMed searches using a variety of combined search terms including ‘pyoderma gangrenosum’, ‘drug‐induced pyoderma gangrenosum’, ‘neutrophilic dermatosis’, ‘treatment’ and ‘therapy’. A list of cases of drug‐induced PG is provided in Table and the proposed pathogenic mechanisms for each drug are illustrated in Figure .…”

Section: Summary Of Each Of the 43 Published Reports Of Drug‐induced mentioning

confidence: 99%

Drug-induced pyoderma gangrenosum: a model to understand the pathogenesis of pyoderma gangrenosum

Patel

Ortega‐Loayza

2017

Br J Dermatol

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This study aimed to explore how drug-induced pyoderma gangrenosum develops in the body. Pyoderma gangreno-sum (PG) is a rare autoinflammatory disease (a genetic disease caused by a malfunctioning immune system) that causes tissue cells to die, resulting in severe and painful ulcers. Drug-induced disease is where a disease occurs, or is triggered, as a result of taking medication/drugs. In this study 43 cases of patients diagnosed with drug-induced PG were reviewed. The authors found that most of the medications associated with drug-induced PG affected more the one element in the pathway that leads to a person developing drug-induced PG. Abnormal neutrophil migration and function, dysregulated inflammation, keratinocyte apoptosis, and alteration of epigenetic mechanisms were all found to be associated with the development of drug-induced PG. Abnormal neutrophil migration and function refers to the irregular movement and function of a specific type of white blood cell (which forms part of the body's immune system). Dysregulated inflammation refers to an abnormal inflammation response in the body's cells and tissue. Ker-atinocyte apoptosis means the death of keratinocyte cells (the cells that form the majority of the outer layer of skin). Alteration of epigenetic mechanisms means a change to the way in which a cell reads and understands its own genes, which in turn affects how the cell behaves. The authors conclude that, in order to better understand how PG develops, further research is needed into the immune system, epigenetics (the way in which a cell reads and acts upon its genes) and NETosis (a form of cell death).

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Section: Summary Of Each Of the 43 Published Reports Of Drug‐induced mentioning

confidence: 99%

Drug-induced pyoderma gangrenosum: a model to understand the pathogenesis of pyoderma gangrenosum

Patel

Ortega‐Loayza

2017

Br J Dermatol

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“…Cutaneous toxicities caused by sunitinib are often seen within the third to fourth weeks of treatment, are often dose‐dependent, and are reversible . These reactions include a hand–foot skin reaction (HFSR) in approximately 10–28% of patients taking sunitinib, facial edema, skin eruptions of varying morphology, subungual splinter hemorrhages, localized eruptions involving the genital skin, eruptive melanocytic nevi, bullous palmoplantar erythrodysesthesia, periungual erythema, mucositis, and pyoderma gangrenosum . Hair changes caused by sunitinib include alopecia and reversible hair depigmentation in around 10–14% of patients .…”

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confidence: 99%

Yellowish nail pigmentation caused by sunitinib

et al. 2016

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“…Drugs reported to cause pyoderma gangrenosum include propylthiouracil, granulocyte colonystimulating factors, interferons and the new 'small-molecule' anticancer drugs gefitinib and sunitinib. [1][2][3][4][5] Hydroxycarbamide is a cytostatic agent that has been used in the treatment of myeloproliferative disorders for over 40 years. Cutaneous adverse effects of hydroxycarbamide are well documented and include xerosis, pigmentary changes, nail discoloration, stomatitis, dermatomyositis-like eruptions and a lichenoid rash on the dorsum of the hands/feet (hydroxyurea dermopathy).…”

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confidence: 99%

“…Occasionally pyoderma gangrenosum occurs as an adverse reaction to drug therapy. Drugs reported to cause pyoderma gangrenosum include propylthiouracil, granulocyte colony‐stimulating factors, interferons and the new ‘small‐molecule’ anticancer drugs gefitinib and sunitinib …”

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confidence: 99%