A 61-year-old woman with a complaint of anemia presented with a flat elevated lesion located in the middle jejunum accompanied by an ulcer at the top of the lesion on oral double-balloon endoscopy. She underwent laparoscopic resection of the jejunum. Pathological findings showed inflammatory cell infiltration and partially lobulated and mildly ectatic capillaries, indicating pyogenic granuloma. Iron deficiency anemia was improved after the operation. Pyogenic granuloma is granulomatous hemangioma that is generally seen in the skin and oral cavity, but rarely in the digestive tract. Pyogenic granuloma can cause obscure gastrointestinal bleeding because it is hemorrhagic.